Abstract:Glycerophospholipids are often overlooked as immediate response elements yet they exert fundamental control over cell viability. They represent the major building blocks of biological membranes and modulate membrane trafficking. Enzymatic processing of choline‐containing membrane phospholipids by cytosolic phospholipase A2 (cPLA2) generates powerful smaller intracellular second messengers (~450–600 Da) as well as arachidonic acid and its metabolites. Individual isoforms control distinct cellular processes, but… Show more
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