Aberrant expression of intelectin-1 in gastric cancer: its relationship with clinicopathological features and prognosis

Zheng, Liduan; Weng, Mixia; Qi, Meng; Qi, Teng; Tong, Ling; Hou, Xiaohua; Tong, Qiangsong

doi:10.1007/s00432-011-1088-8

Cited by 40 publications

(42 citation statements)

References 33 publications

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“…A series of reports indicated the potential role of intelectin-1 in carcinogenesis [64,65,66,67,68,69,70,71]. With respect to gastrointestinal carcinogenesis, Li et al reported that intelectin-1 increased the levels of hepatocyte nuclear factor 4 α (HNF4α), resulting in the suppression of the nuclear translocation and transcriptional activity of β-catenin in gastric cancer cells [70].…”

Section: Intelectin-1 In Colorectal Carcinogenesismentioning

confidence: 99%

Adiponectin and Intelectin-1: Important Adipokine Players in Obesity-Related Colorectal Carcinogenesis

Kawashima

Maeda

Saigo

et al. 2017

IJMS

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Overweight is believed to be associated with colorectal cancer risk. Adipose tissue is loose connective tissue composed of adipocytes. It is now recognized as a major endocrine organ, secreting humoral factors collectively called adipokines. Aberrant hormonal systems consisting of modulated adipokines and their receptors are thought to play a role in colorectal carcinogenesis and cancer progression in obese conditions. However, it is still unclear whether and how each adipokine relates to colorectal carcinogenesis. Notably, a couple of molecules that were initially proposed to be obesity-related adipokines were disqualified by subsequent studies. The adipokines, adiponectin, and intelectin-1 (also known as omentin-1), whose levels are decreased in obesity, act as tumor suppressor factors in various cancers. Numerous studies have demonstrated a link between the insufficient expression and function of adiponectin and its receptor, T-cadherin, in colorectal carcinogenesis. Moreover, our recent study indicated that loss of TMEM207, which is critical for the proper processing of intelectin-1 in the colon mucosa, leads to insufficient intelectin-1 production, thus participating in colorectal carcinogenesis. Here, we discuss the recent understanding of the role of adipokines in colorectal carcinogenesis and subsequently describe the potent tumor suppressor roles of intelectin-1 and TMEM207 in colorectal cancer.

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Section: Intelectin-1 In Colorectal Carcinogenesismentioning

confidence: 99%

Adiponectin and Intelectin-1: Important Adipokine Players in Obesity-Related Colorectal Carcinogenesis

Kawashima

Maeda

Saigo

et al. 2017

IJMS

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“…ITLN1 is over-expressed in human malignant pleural mesothelioma (MPM) and secreted into pleural effusions, and serves as a biomarker for differentiating from lung cancer [14,15]. Our previous studies have shown that ITLN1 is aberrantly expressed in gastric cancer tissues, and is correlated with clinicopathological features, suggesting its value as a useful prognostic factor for gastric cancer patients [16]. However, the expression profiles, exact functions, and downstream targets of ITLN1 in NB still remain elusive.…”

Section: Introductionmentioning

confidence: 99%

Intelectin 1 suppresses the growth, invasion and metastasis of neuroblastoma cells through up-regulation of N-myc downstream regulated gene 2

Hong

et al. 2015

Mol Cancer

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“…On the other hand, knocking down omentin‐1 increased prostate cancer cell proliferation , suggesting a tumour suppressive activity. Clinical studies also support these results: it has been observed that omentin‐1 transcript levels are elevated in gastric cancer tissues compared with normal gastric mucosa and is an independent prognostic factor for longer survival in these patients . In addition, an inverse association has been found between omentin‐1 positivity obtained by immunohistochemistry and Ki67 (a marker of proliferative capacity), heparanase (involved in the invasion and metastasis) and other parameters related to higher tumour malignancy , suggesting that omentin‐1 might act as a tumour suppressor in gastric cancer.…”

Section: Novel Adipocytokines Potentially Involved In Obesity‐relatedmentioning

confidence: 71%

“…Clinical studies also support these results: it has been observed that omentin‐1 transcript levels are elevated in gastric cancer tissues compared with normal gastric mucosa and is an independent prognostic factor for longer survival in these patients . In addition, an inverse association has been found between omentin‐1 positivity obtained by immunohistochemistry and Ki67 (a marker of proliferative capacity), heparanase (involved in the invasion and metastasis) and other parameters related to higher tumour malignancy , suggesting that omentin‐1 might act as a tumour suppressor in gastric cancer. Other clinical studies have also reported higher serum omentin‐1 levels in patients with prostate cancer or colon cancer , although the relation with tumour aggressiveness has not been observed or assessed.…”

Section: Novel Adipocytokines Potentially Involved In Obesity‐relatedmentioning

confidence: 71%

A role for novel adipose tissue‐secreted factors in obesity‐related carcinogenesis

et al. 2016

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Obesity, a pandemic disease, is caused by an excessive accumulation of fat that can have detrimental effects on health. Adipose tissue plays a very important endocrine role, secreting different molecules that affect body physiology. In obesity, this function is altered, leading to a dysfunctional production of several factors, known as adipocytokines. This process has been linked to various comorbidities associated with obesity, such as carcinogenesis. In fact, several classical adipocytokines with increased levels in obesity have been demonstrated to exert a pro-carcinogenic role, including leptin, TNF-α, IL-6 and resistin, whereas others like adiponectin, with decreased levels in obesity, might have an anti-carcinogenic function. In this expanding field, new proteomic techniques and approaches have allowed the identification of novel adipocytokines, a number of which exhibit an altered production in obesity and type 2 diabetes and thus are related to adiposity. Many of these novel adipocytokines have also been identified in various tumour types, such as that of the breast, liver or endometrium, thereby increasing the list of potential contributors to carcinogenesis. This review is focused on the regulation of these novel adipocytokines by obesity, including apelin, endotrophin, FABP4, lipocalin 2, omentin-1, visfatin, chemerin, ANGPTL2 or osteopontin, emphasizing its involvement in tumorigenesis.

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Aberrant expression of intelectin-1 in gastric cancer: its relationship with clinicopathological features and prognosis

Abstract: The aberrant ITLN-1 expression in gastric cancer is correlated with clinicopathological features and may be a useful prognostic factor for predicting the outcomes of gastric cancer patients.

Cited by 40 publications

References 33 publications

Adiponectin and Intelectin-1: Important Adipokine Players in Obesity-Related Colorectal Carcinogenesis

Adiponectin and Intelectin-1: Important Adipokine Players in Obesity-Related Colorectal Carcinogenesis

Intelectin 1 suppresses the growth, invasion and metastasis of neuroblastoma cells through up-regulation of N-myc downstream regulated gene 2

A role for novel adipose tissue‐secreted factors in obesity‐related carcinogenesis

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