Aberrant Expression of
            <i>PlncRNA-1</i>
            and
            <i>TUG1</i>
            : Potential Biomarkers for Gastric Cancer Diagnosis and Clinically Monitoring Cancer Progression

Baratieh, Zohreh; Khalaj, Zahra; Honardoost, Mohammad Amin; Emadi‐Baygi, Modjtaba; Khanahmad, Hossein; Salehi, Mansoor; Nikpour, Parvaneh

doi:10.2217/bmm-2017-0090

Cited by 43 publications

(43 citation statements)

References 35 publications

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“…A research group found that FAM83H-AS1 was a crucial lncRNA expressed at preliminary stage of breast cancer by RNA sequencing in early-stage tumors, suggesting detection of FAM83H-AS1 expression levels in plasma could be a potential diagnostic and prognostic biomarker for early-stage of breast cancer [33]. However, in contrast to other reports, Baratieh's study showed that upregulated expression of FAM83H-AS1 in kidney renal papillary cell carcinoma led to longer survival rates [14]. Chemotherapy is one of the most effective methods to treat tumors and is the main treatment for some tumors that have the tendency of metastasis and those that have already metastasized.…”

Section: Discussionmentioning

confidence: 99%

“…The 14 studies contained 2818 patients from three countries including China, United States and Iran. We mainly analyzed nine different types of tumors, including pancreatic ductal adenocarcinoma [13], gastric cancer [7,14,15], ovarian cancer [8,16], glioma [9], colorectal carcinoma [17,18], bladder cancer [10], hepatocellular carcinoma [6], breast cancer [19], and lung cancer [20]. The expression of FAM83H-AS1 was detected by quantitative real-time fluorescent PCR in all studies.…”

Section: Characteristics and Basic Information In Eligible Literaturementioning

confidence: 99%

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The clinical prognostic value of lncRNA FAM83H-AS1 in cancer patients: a meta-analysis

Yang¹,

Wang²,

Zhong³

et al. 2020

Cancer Cell Int

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Background: Family with sequence similarity 83 member H antisense RNA 1 (FAM83H-AS1) is a novel long noncoding RNA. Increasing studies have reported that FAM83H-AS1 is abnormally expressed in a variety of tumors and is associated with poor outcome. However, the clinical prognostic significance of lncRNA FAM83H-AS1 in tumors is not completely known. Methods:In this meta-analysis, literature was collected up until February 5, 2020 through multifarious retrieval strategies by searching through electronic databases of PubMed, Cochrane Library, EMBASE, Medline, Web of Science, CNKI, Weipu, and Wanfang. A total of 14 studies that met the inclusion criteria with relevant clinical data and prognostic information were included in the meta-analysis. Results:The combined results revealed that high expression of FAM83H-AS1 was associated with poor overall survival (OS) (HR = 1.63, 95% CI 1.24-2.14, P = 0.0004) in a variety of cancers. Additionally, upregulated FAM83H-AS1 expression was significantly correlated with tumor TNM stage (III/IV vs. I/II, OR = 2.40, 95% CI 1.36-4.23, P = 0.003) and lymph node metastasis (positive vs. negative, OR = 1.70, 95% CI 1.14-2.52, P = 0.008) in patients with cancer. Conclusions:Our results of this meta-analysis indicated that elevated FAM83H-AS1 expression could predict poor prognosis in patients with cancer and suggested that FAM83H-AS1 might serve as a novel biomarker for cancer.

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Section: Discussionmentioning

confidence: 99%

Section: Characteristics and Basic Information In Eligible Literaturementioning

confidence: 99%

The clinical prognostic value of lncRNA FAM83H-AS1 in cancer patients: a meta-analysis

Yang¹,

Wang²,

Zhong³

et al. 2020

Cancer Cell Int

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“…It has been revealed that there were significant higher levels of PlncRNA-1 and TUG1 expressions in a sub population of Iranian GC tissues compared with normal margins. The PlncRNA-1 expression level was correlated with sex in which female patients had a significantly PlncRNA-1 over expression compared with males [97]. PlncRNA-1 expression level was significantly over expressed in Chinese HCC tissues that was significantly associated with tumor size and advanced TNM stage [98].…”

Section: Gastric Cancermentioning

confidence: 95%

“…PlncRNA-1 is encoded from the antisense strand of the carbonyl reductase 3 (CBR3) on chromosome 21q. PlncRNA-1 is over expressed in various cancers including PCa, ESCC, and hepatocellular carcinoma (HCC) [97]. It has been revealed that there were significant higher levels of PlncRNA-1 and TUG1 expressions in a sub population of Iranian GC tissues compared with normal margins.…”

Section: Gastric Cancermentioning

confidence: 99%

Long non-coding RNAs as the critical factors during tumor progressions among Iranian population: an overview

2020

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Background: Cancer is associated with various genetic and environmental risk factors. Beside the mutations or aberrant expression of protein-coding genes, the genetic deregulation of non-coding RNAs has also an important role during tumor progression and metastasis. Long non-coding RNAs (lncRNAs) are a class of ncRNAs larger than 200 nucleotides that may function as tumor-suppressor or oncogene. Main body:There is a raising trend of cancer incidence among Iranian population during the last decades. Therefore, it is required to prepare a general population specific panel of genetic markers for the early detection of cancer in this population. The tissue-specific expression characteristics and high stability in body fluids highlight the lncRNAs as efficient diagnostic and prognostic noninvasive biomarkers in cancer. In present review we summarized all of the lncRNAs which have been reported until now in different tumors among Iranian patients. Conclusions:This review paves the way of introducing a population based noninvasive diagnostic panel of lncRNAs for the early detection of tumor cells among Iranian population.

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“…A total of 30 pairs of gastric cancer and matched adjacent nontumoral tissues were obtained from patients with gastric cancer. The specimens were collected by the Iran National Tumor Bank, which is funded by the Cancer Institute of Tehran University, for Cancer Research (19)(20)(21). There, the tissues are immediately snap-frozen in the liquid nitrogen.…”

Section: Clinical Specimensmentioning

confidence: 99%

Down-regulation of circular RNAITCH and circHIPK3 in gastric cancer tissues

GHASEMI¹

2019

Turk J Med Sci

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Background/aim: Gastric cancer (GC) is one of the major causes of cancer mortality worldwide. As a novel type of endogenous noncoding RNAs, circular RNAs (circRNAs) are formed by a covalent link between 5' and 3' ends. They are very stable and abundant in eukaryotes. As there were no reported studies on the expression profiles of circular RNA ITCH (cir-ITCH) and circHIPK3 in GC, in the current study, we aimed to delineate the expression profiles and clinicopathological relevance of these two circRNAs in GC tissues compared to their paired adjacent noncancerous tissues. Materials and methods: Quantitative real-time polymerase chain reaction was performed to evaluate cir_ITCH and circHIPK3 expression in 30 paired gastric cancer tissues. The clinicopathological relevance of these two circular RNAs' expression levels with gastric cancer was further examined. Results: Our results showed that the expression of cir_ITCH and circHIPK3 were significantly downregulated in GC tumoral tissues compared with their paired adjacent nonneoplastic counterparts. Further analyses showed that cir_ITCH and circHIPK3 expression levels were related with numerous clinicopathological features of tumoral tissues. Conclusion: Cir_ITCH and circHIPK3 may have imperative roles in GC and serve in the future as potential prognostic biomarkers in GC.

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Aberrant Expression of PlncRNA-1 and TUG1 : Potential Biomarkers for Gastric Cancer Diagnosis and Clinically Monitoring Cancer Progression

Abstract: In conclusion, PlncRNA-1 and TUG1 genes may play a critical role in GC progression and may serve as potential diagnostic biomarkers in GC patients.

Cited by 43 publications

References 35 publications

The clinical prognostic value of lncRNA FAM83H-AS1 in cancer patients: a meta-analysis

The clinical prognostic value of lncRNA FAM83H-AS1 in cancer patients: a meta-analysis

Long non-coding RNAs as the critical factors during tumor progressions among Iranian population: an overview

Down-regulation of circular RNAITCH and circHIPK3 in gastric cancer tissues

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