Aberrant expression of glutathione peroxidase in eutopic and ectopic endometrium in endometriosis and adenomyosis

Ota, Hirotaka; Igarashi, Shigeru; Kato, Naohiko; Tanaka, Toshinobu

doi:10.1016/s0015-0282(00)00638-5

Cited by 85 publications

(59 citation statements)

References 23 publications

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“…Furthermore, studies of single nucleotide polymorphism s reveal that GSTT1 (glutathione-S-transferase) null deletion [36] and eNOS [20] are associated with moderate risk of endometriosis. In addition, endometriosis-related infertility is associated with glutathione peroxidase activity [29]. Taken together, the oviduct in patients with endometriosis might be a microenvironment featuring excess NO and insufficient glutathione.…”

Section: Discussionmentioning

confidence: 99%

“…In addition to NOS, the tubal epithelium synthesizes or expresses several types of antioxidants and enzymes, such as glutathione, superoxide dismutase, and glutathione reductase [13]. Glutathione peroxidase activity has been implicated in endometriosisrelated infertility [29]. Furthermore, carriage of the GSTT1 (glutathione-S-transferase) null deletion is associated with moderate risk of endometriosis [36].…”

Section: Introductionmentioning

confidence: 99%

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Nitric oxide modulates mitochondrial activity and apoptosis through protein S-nitrosylation for preimplantation embryo development

Lee¹,

Lee²,

Huang³

et al. 2013

J Assist Reprod Genet

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Purpose Previous studies reported that patients with endometriosis had excess nitric oxide (NO) in the reproductive tract and poor embryo development in IVF cycles. This study aims to elucidate the effects of NO on early embryo development. Methods Zygotes from superovulated B6CBF1 mice were cultured to blastocysts in a variety of media. Sodium nitroprusside (SNP) and N G -nitro-L-arginine (LNA) were added to the culture medium as a NO donor and a NO synthase inhibitor, respectively. The localization and fluorescence intensity of S-nitrosylated (SNO) proteins within 2-cell stage embryos were analyzed with confocal microscopy. Apoptosis and ATP production in the blastocysts were measured. Result(s) Subsequent to NO exposure, the SNO proteins mainly colocalized with the mitochondria and endoplasmic reticulum and the intensity of SNO proteins increased. The addition of a quanylate cyclase inhibitor and a cyclic GMP mimic agent induced nonsignificant changes in SNO proteins, whereas addition of a superoxide scavenger or a reduced form of glutathione rescued the embryos from the effects of NO. However, superoxide scavenger supplementation resulted in decreased blastocyst ATP production. Conclusion(s) Elevated NO exerts deleterious effects on embryo development, possibly through protein S-nitrosylation in the mitochondria and endoplasmic reticulum. Including glutathione as a component in the culture medium might counteract this effect.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Nitric oxide modulates mitochondrial activity and apoptosis through protein S-nitrosylation for preimplantation embryo development

Lee¹,

Lee²,

Huang³

et al. 2013

J Assist Reprod Genet

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“…Эндометрий при аденомиозе отличается в аспектах клеточного и гуморального иммунитета от нормального эндометрия [1,2,3,4,5,6]. Эти различия могут быть результатом структурных на-рушений.…”

Section: âведениеunclassified

Clinical and Immunological Changes in Treatment of Adenomyosis in Patients With Infertility

Karakhalis¹,

Jhigalenko²,

Penjhoyan³

et al. 2017

Kuban. nauсh. med. vestnik

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Федеральное государственное бюджетное образовательное учреждение высшего образования «Кубанский государственный медицинский университет» Министерства здравоохранения Российской Федерации, ул. Седина, д. 4, Краснодар, Россия, 350063 АННОТАЦИЯ Цель. Определить изменения молекул адгезии (L-селектин, неоптерин и интерлейкин-6) у пациенток с адено-миоз-ассоциированным бесплодием в динамике на фоне терапии.Материалы и методы. Обследовано 49 пациенток с бесплодием на фоне аденомиоза, сформированы 3 клини-ческие группы: 1 группа -26 пациенток (35,1%) и 2 группа -23 пациентки (31,1%) с аденомиоз-ассоциированным бесплодием, 3 группа (контрольная) − 25 пациенток (33,8%). Определение молекул адгезии проводили при помощи иммунно-ферментного анализа (ИФА). Оценка клинических проявлений аденомиоза проводилась по визуально аналоговой шкале (ВАШ).Результаты. Показана диагностическая значимость L-cелектина для контроля эффективности терапии аде-номиоза. Отличие L-селектина до и после лечения статистически значимо и коэффициент корреляции (R) равен 0,584. Использование гестагенов предпочтительно в связи с достоверной нормализацией L-селектина и снижени-ем интенсивности по ВАШ проявлений альгоменореи: в 1 группе в 1,3 раза меньше, чем во 2-ой и диспареуния: в 1 группе в 2,2 раза меньше, чем во 2-ой.Заключение. Аденомиоз не сопровождается существенным возрастанием продукции маркеров системного воспалительного ответа (неоптерина и ИЛ-6), повышение числа адгезивных молекул (L-селектина) свидетельству-ет о наличии дисбаланса эндотелиально-тромбоцитарно-лейкоцитарных взаимодействий. CLINICAL AND IMMUNOLOGICAL CHANGES IN TREATMENT OF ADENOMYOSIS IN PATIENTS WITH INFERTILITY Federal State Budgetary Educational Institution of Higher Education Kuban State Medical University of the Ministry of Healthcare of the Russian Federation, Sedina str., 4, Krasnodar, Russia, 350063ABSTRACT Aim. The aim of this study was to asses changes of adhesion molecules (L-selectin, neopterin and interleukin-6) in patients with adenomyosis-related infertility during the therapy. Materials and methods. 49 patients with infertility caused by adenomyosis were examined and divided into 3 clinical groups: 1 group -26 patients (35,1%) and 2 group -23 patients (31,1%) with adenomyosis-associated infertility; 3 group (control) -25 patients (33,8%). Adhesion molecules detection was performed by enzyme immunoassay (EIA). Visual evaluation scale was used for estimating of clinical aspects of adenomyosis.Results. The diagnostic utility of L-selectin for monitoring the adenomyosis therapy effectiveness was shown. The difference between L-selectin levels before and after treatment was statistically significant, the correlation coefficient (R) reached 0,584. The gestagens application is preferable due to reliable normalization of L-selectin levels and decrease in intensity of algomenorrhea (in the 1 st group -1,3 times less, than in 2 nd group) and dyspareunia (in the 1 st group -2,2 times less, than in the 2 nd group) on visual evaluation scale. Conclusions. Adenomyosis n...

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“…Inducers of oxidative stress may include erythrocytes, apoptotic endometrial cells, and undigested endometrial cells in the menstrual effluent (10). Several studies have indicated that antioxidant defences may be altered in endometriosis, as suggested by the aberrant expression of endometrial antioxidant enzymes and lower levels of the antioxidant vitamin E in peritoneal fluid (11)(12)(13)(14). Endometriosis has the unique characteristics of invasion and requires the remodelling of the extracellular matrix (ECM) (15)(16)(17).…”

Section: Introductionmentioning

confidence: 99%

Melatonin treatment results in regression of endometriotic lesions in an ooferectomized rat endometriosis model

Kocadal¹,

Attar²,

Yıldırım³

et al. 2013

J Turkish German Gynecol Assoc

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Objective: We aimed to determine the effects of melatonin treatment on endometrial implants in an oopherectomized rat endometriosis model. Material and Methods:This study is a prospective, randomised, controlled experimental study. It was carried out at the Experimental Research Center of Yeditepe University (YUDETAM). Twenty-two, female, non-pregnant, nulligravid Spraque-Dawley albino rats were included in our study. Endometriosis was surgically induced in oopherectomized rats. Rats were randomised into two groups: control group and melatonin group. In the melatonin group, rats were treated with melatonin (20 mg/kg/day) for two weeks. After the operations were performed to assess the regression of the endometriotic lesions, melatonin treatment was stopped. At the end of the sixth week necropsies were performed to assess the rate of recurrence. The volume and histopathological scores of endometriotic foci were examined.Results: Volumes of the endometriotic lesions significantly decreased in the melatonin group. Also, when the melatonin group was analysed within itself, endometriotic lesion volumes decreased and histopathological scores increased significantly. Conclusion: Abstract ÖzetOriginal Investigation 81

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Aberrant expression of glutathione peroxidase in eutopic and ectopic endometrium in endometriosis and adenomyosis

Cited by 85 publications

References 23 publications

Nitric oxide modulates mitochondrial activity and apoptosis through protein S-nitrosylation for preimplantation embryo development

Nitric oxide modulates mitochondrial activity and apoptosis through protein S-nitrosylation for preimplantation embryo development

Clinical and Immunological Changes in Treatment of Adenomyosis in Patients With Infertility

Melatonin treatment results in regression of endometriotic lesions in an ooferectomized rat endometriosis model

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