Aberrant Expression of Claudins in Head and Neck Carcinomas and Their Prognostic and Therapeutic Value: A Narrative Review

Arabi, Tarek Ziad; Algheryafi, Linah Abdulmohsen; Alodah, Nora A.; Enabi, Hamza M. Kossai; Alshehry, Amjad Abdullah; Ouban, Abderrahman

doi:10.3390/cancers15174208

Cited by 3 publications

(2 citation statements)

References 77 publications

(123 reference statements)

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“…The barrier function of the epithelium is primarily maintained by tight junction proteins composed of zona-occludins, desmosomes, and claudins, among others ( Arabi et al, 2023 ). The claudin family consists of 27 transmembrane proteins ( Tsukita et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

“…Emerging evidence has demonstrated that abnormal claudin expression can mediate tumorigenic processes in several cancers, including head and neck, gastrointestinal, breast, and lung neoplasms ( Soini, 2011 ; Zhu et al, 2019 ; Yadav et al, 2022 ; Arabi et al, 2023 ). Additionally, aberrant expression of these proteins can be seen in preneoplastic conditions, highlighting their possible role for early detection and treatment of tumors ( Ouban and Arabi, 2023 ).…”

Section: Introductionmentioning

confidence: 99%

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Claudins in genitourinary tract neoplasms: mechanisms, prognosis, and therapeutic prospects

Arabi,

Fawzy,

Sabbah

et al. 2023

Front. Cell Dev. Biol.

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Genitourinary (GU) cancers are among the most prevalent neoplasms in the world, with bladder cancers constituting 3% of global cancer diagnoses. However, several pathogenetic mechanisms remain controversial and unclear. Claudins, for example, have been shown to play a significant role in several cancers of the human body. Their role in GU cancers has not been extensively studied. Aberrant expression of claudins −1, −2, −3, −4, −7, and −11 has been expressed in urothelial cell carcinomas. In prostate cancers, altered levels of claudins −1, −2, −3, −4, and −5 have been reported. Furthermore, the levels of claudins −1, −2, −3, −4, −6, −7, −8, and −10 have been studied in renal cell carcinomas. Specifically, claudins −7 and −8 have proven especially useful in differentiating between chromophobe renal cell carcinomas and oncocytomas. Several of these claudins also correlate with clinicopathologic parameters and prognosis in GU cancers. Although mechanisms underpinning aberrant expression of claudins in GU cancers are unclear, epigenetic changes, tumor necrosis factor-ɑ, and the p63 protein have been implicated. Claudins also provide therapeutic value through tailored immunotherapy via molecular subtyping and providing therapeutic targets, which have shown positive outcomes in preclinical studies. In this review, we aim to summarize the literature describing aberrant expression of claudins in urothelial, prostatic, and renal cell carcinomas. Then, we describe the mechanisms underlying these changes and the therapeutic value of claudins. Understanding the scope of claudins in GU cancers paves the way for several diagnostic, prognostic, and therapeutic innovations.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Claudins in genitourinary tract neoplasms: mechanisms, prognosis, and therapeutic prospects

Arabi,

Fawzy,

Sabbah

et al. 2023

Front. Cell Dev. Biol.

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Clinical significance and biological role of claudin-1 in oral squamous cell carcinoma cells

Nobumoto,

Yamasaki,

Hamada

et al. 2024

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

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Deciphering the role of claudins in lung cancer

Arabi,

Alkattan,

Osman

et al. 2024

Front. Oncol.

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Lung cancer remains a major global health challenge, characterized by aggressive malignancy and poor prognostic outcomes. This review article focuses on the pivotal role of claudins, a family of tight junction proteins, in the pathophysiology of lung cancer. Claudins are integral to maintaining epithelial barrier function and cellular polarity, yet they are intricately involved in the progression and metastasis of lung cancer. The aberrant expression of claudins has been observed across various histological subtypes of lung cancer, indicating their potential as diagnostic and prognostic biomarkers. Specifically, claudins such as claudin-1, -2, -3, -4, and -7 exhibit diverse expression patterns that correlate with tumor aggressiveness, patient survival rates, and response to therapies. Inflammation and cytokine modulation significantly influence claudin expression, affecting tumor microenvironment dynamics and cancer progression. This review also highlights the therapeutic implications of targeting claudins, particularly in cases resistant to conventional treatments. Recent advances in this area suggest that claudin-modulating agents may enhance the efficacy of existing therapies and offer new avenues for targeted interventions. By integrating the latest research, this article aims to provide a comprehensive understanding of claudin’s roles in lung cancer and encourages further clinical trials to explore claudin-targeting therapies. This could pave the way for more effective management strategies, improving outcomes for lung cancer patients.

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Aberrant Expression of Claudins in Head and Neck Carcinomas and Their Prognostic and Therapeutic Value: A Narrative Review

Cited by 3 publications

References 77 publications

Claudins in genitourinary tract neoplasms: mechanisms, prognosis, and therapeutic prospects

Claudins in genitourinary tract neoplasms: mechanisms, prognosis, and therapeutic prospects

Clinical significance and biological role of claudin-1 in oral squamous cell carcinoma cells

Deciphering the role of claudins in lung cancer

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