Aberrant expression of B7-H3 in gastric adenocarcinoma promotes cancer cell metastasis

Dai, Wei; Shen, Genhai; Qiu, Jianping; Zhao, Xin; Gao, Quangen

doi:10.3892/or.2014.3405

Cited by 45 publications

(44 citation statements)

References 32 publications

(31 reference statements)

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“…Recently, B7-H3 expression has been shown in several cancer types including acute leukemia, gastric, pancreatic, renal, liver, lung, bone, colon, prostate, ovarian, endometrial, and breast cancer (35–47). However, its role in immune response, including tumor immunity of different cancer types, remains unclear and controversial (33, 48, 49).…”

Section: Discussionmentioning

confidence: 99%

“…However, its role in immune response, including tumor immunity of different cancer types, remains unclear and controversial (33, 48, 49). Both T-cell co-stimulatory and inhibitory functions have been shown in various cancer types and B7-H3 expression has been correlated with both favorable and poor prognosis in cancer patients (33, 35, 50). For example, in human gastric adenocarcinomas, B7-H3 expression was associated with prolonged patient survival compared to receptor negative tumors (50).…”

Section: Discussionmentioning

confidence: 99%

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Breast Cancer Detection by B7-H3–Targeted Ultrasound Molecular Imaging

et al. 2015

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Ultrasound complements mammography as an imaging modality for breast cancer detection, especially in patients with dense breast tissue, but its utility is limited by low diagnostic accuracy. One emerging molecular tool to address this limitation involves contrast-enhanced ultrasound using microbubbles targeted to molecular signatures on tumor neovasculature. In this study, we illustrate how tumor vascular expression of B7-H3 (CD276), a member of the B7 family of ligands for T cell co-regulatory receptors, can be incorporated into an ultrasound method that can distinguish normal, benign, precursor and malignant breast pathologies for diagnostic purposes. Through an immunohistochemical analysis of 248 human breast specimens, we found that vascular expression of B7-H3 was selectively and significantly higher in breast cancer tissues. B7-H3 immunostaining on blood vessels distinguished benign/precursors from malignant lesions with high diagnostic accuracy in human specimens. In a transgenic mouse model of cancer, the B7-H3-targeted ultrasound imaging signal was increased significantly in breast cancer tissues and highly correlated with ex vivo expression levels of B7-H3 on quantitative immunofluorescence. Our findings offer a preclinical proof of concept for the use of B7-H3-targeted ultrasound molecular imaging as a tool to improve the diagnostic accuracy of breast cancer detection in patients.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Breast Cancer Detection by B7-H3–Targeted Ultrasound Molecular Imaging

et al. 2015

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“…found in a variety of different human cancers, including prostate (19,20), nonsmall cell lung (NSCLC) (21), gastric (22,23), pancreatic (24), ovarian (25), colorectal (26), urothelial cell (27), clear cell renal cell (ccRCC) (28), and hypopharyngeal (29) cancers.…”

mentioning

confidence: 99%

Glycoprotein B7-H3 overexpression and aberrant glycosylation in oral cancer and immune response

Chen

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

104

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The incidence and mortality rate of oral cancer continue to rise, partly due to the lack of effective early diagnosis and increasing environmental exposure to cancer-causing agents. To identify new markers for oral cancer, we used a sialylation probe to investigate the glycoproteins differentially expressed on oral cancer cells. Of the glycoproteins identified, B7 Homolog 3 (B7-H3) was significantly overexpressed in oral squamous cell carcinoma (OSCC), and its overexpression correlated with larger tumor size, advanced clinical stage, and low survival rate in OSCC patients. In addition, knockdown of B7-H3 suppressed tumor cell proliferation, and restoration of B7-H3 expression enhanced tumor growth. It was also found that the N-glycans of B7-H3 from Ca9-22 oral cancer cells contain the terminal α-galactose and are more diverse with higher fucosylation and better interaction with DC-SIGN [DC-specific intercellular adhesion molecule-3 (ICAM-3)-grabbing nonintegrin] and Langerin on immune cells than that from normal cells, suggesting that the glycans on B7-H3 may also play an important role in the disease.CD276 | proliferation | glycan sequencing | terminal α-galactose | fucose

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“…Although B7‐H3 is considered to have two opposing characteristics as a co‐inhibitory or co‐stimulatory mediator in T‐cell‐mediated immunity, B7‐H4 is known to function as a negative modulator of immune responses 43. Immunohistochemical studies showed that B7‐H3 and B7‐H4 were abundantly expressed in the primary tumor cells of patients with gastric cancer 45, 46. Accordingly, these immune checkpoint molecules have potential as CTC‐targeted markers to predict tumor responses to chemotherapy and prognoses in the clinical management of patients with gastric cancer.…”

Section: Detection Of Ctcmentioning

confidence: 99%

Clinical significance of circulating tumor cells in blood from patients with gastric cancer

Arigami

Uenosono

Yanagita

et al. 2017

Annals of Gastroent Surgery

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Circulating tumor cells (CTC) have been focused on as a target for detecting occult tumors, predicting therapeutic responses and prognoses, and monitoring postoperative recurrence in the clinical management of patients with various malignancies, including gastric cancer. Recent advances in molecular diagnostic tools have contributed to high sensitivity and specificity for the detection of CTC. A conspicuous disparity exists in the incidence of CTC among studies. However, a close relationship has been reported between positivity for CTC and well‐known prognostic clinicopathological factors including depth of tumor invasion, lymph node metastasis, stage, and lymphatic and venous invasion in patients with gastric cancer. According to most studies published on the clinical impact of CTC, the presence of CTC negatively affects the prognosis of patients with gastric cancer. Moreover, the study of CTC based on a meta‐analysis demonstrated their importance as a poor prognostic indicator. In clinical management, pre‐ and post‐therapeutic monitoring of CTC using liquid biopsy may be useful for early detection of subclinical patients or disease recurrence, prediction of tumor progression, and administrative control of adjuvant chemotherapy. Although their functional properties remain unclear, molecular profiling of CTC may contribute to the development of personalized treatment that effectively inhibits tumor progression in patients with advanced gastric cancer. We herein review the clinical significance of CTC as a promising blood marker and therapeutic target in patients with gastric cancer.

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Aberrant expression of B7-H3 in gastric adenocarcinoma promotes cancer cell metastasis

Cited by 45 publications

References 32 publications

Breast Cancer Detection by B7-H3–Targeted Ultrasound Molecular Imaging

Breast Cancer Detection by B7-H3–Targeted Ultrasound Molecular Imaging

Glycoprotein B7-H3 overexpression and aberrant glycosylation in oral cancer and immune response

Clinical significance of circulating tumor cells in blood from patients with gastric cancer

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