Aberrant ER-mitochondria communication is a common pathomechanism in mitochondrial disease
Patricia Morcillo,
Khushbu Kabra,
Kevin Velasco
et al.
Abstract:Genetic mutations causing primary mitochondrial disease (i.e those compromising oxidative phosphorylation [OxPhos]) resulting in reduced bioenergetic output display great variability in their clinical features, but the reason for this is unknown. We hypothesized that disruption of the communication between endoplasmic reticulum (ER) and mitochondria at mitochondria-associated ER membranes (MAM) might play a role in this variability. To test this, we assayed MAM function and ER-mitochondrial communication in Ox… Show more
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