Aberrant Effective Connectivity of the Right Anterior Insula in Primary Insomnia

Li, Chao; Dong, Mengshi; Yin, Yi; Hua, Kelei; Fu, Shishun; Jiang, Guihua

doi:10.3389/fneur.2018.00317

Cited by 29 publications

(19 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In terms of the association among these networks, the key switching role of SN in the modulation of DMN and ECN has been well-documented ( 17 , 19 – 21 ). The right anterior insula in SN plays a key role in modulating ECN and DMN for better task performance ( 51 ). An intact SN drives DMN and ECN during resting and task states, respectively, and contributes to maintaining normal cognitive function in healthy young ( 52 ) and old ( 21 ) subjects.…”

Section: Discussionmentioning

confidence: 99%

Changes in Brain Function Networks in Patients With Amnestic Mild Cognitive Impairment: A Resting-State fMRI Study

Wang

Liu

et al. 2020

Front. Neurol.

View full text Add to dashboard Cite

Patients with amnestic mild cognitive impairment (aMCI) are at high risk of developing dementia. This study used resting-state functional magnetic resonance imaging (rs-fMRI) and an independent component analysis (ICA) approach to explore changes in functional connectivity (FC) in the default mode network (DMN), executive control network (ECN), and salience network (SN). Thirty patients with aMCI and 30 healthy controls (HCs) were enrolled. All the participants underwent an rs-fMRI scan. The brain FC in DMN, ECN, and SN was calculated using the ICA approach. We found that the FC of brain regions in DMN decreased significantly and that of brain regions in ECN increased, which was in accordance with the findings of previous studies on Alzheimer's disease (AD) and aMCI. We also found that the FC of brain regions in SN increased, which was different from the findings of previous studies on AD. The increase in FC in brain regions in SN might result from different pathophysiological states in AD and aMCI, indicating that a decrease in FC in SN does not occur in a person with aMCI. These results are consistent with those of previous studies using the voxel-mirrored homotopic connectivity approach and seed-based correlation analysis. We therefore considered that the decrease in FC in DMN and the increase in FC in ECN and SN might be peculiar patterns observed on the rs-fMRI of a person with aMCI. These findings may contribute to the development of imaging biomarkers for the diagnosis of aMCI.

show abstract

Section: Discussionmentioning

confidence: 99%

Changes in Brain Function Networks in Patients With Amnestic Mild Cognitive Impairment: A Resting-State fMRI Study

Wang

Liu

et al. 2020

Front. Neurol.

View full text Add to dashboard Cite

show abstract

“…The correlation between the AIC BOLD and EEG gamma frequency power was also greater reflecting negative affect in PI (12). While, the effective connectivity of the AIC was found decreased in PI (45). Combing with these evidences, the increased variance of dALFF might reflect overactive but ineffective activity of the AIC in PI.…”

Section: Discussionmentioning

confidence: 76%

Increased Dynamic Amplitude of Low Frequency Fluctuation in Primary Insomnia

et al. 2020

Self Cite

View full text Add to dashboard Cite

The physiological mechanism underlying primary insomnia (PI) is poorly understood. Resting-state functional magnetic resonance imaging (fMRI) has emerged as a powerful tool to explore PI. However, previous studies ignore the dynamics of the brain activity. In the current study, we aimed to explore altered dynamic intrinsic brain activity in PI. Fifty-nine patients with PI and 47 matched healthy controls (HCs) were recruited and underwent resting-state fMRI. The variance of dynamic amplitude of low frequency fluctuation (dALFF) maps across time was calculated to measure the temporal variability of intrinsic brain activity and then compared between patients with PI and HCs. As a result, patients with PI presented increased variance of dALFF in the bilateral hippocampus extending to the parahippocampus, the right putamen and the right anterior insula cortex. In addition, the variance of dALFF in the right putamen was positively correlated with Self-rating Anxiety Scale (SAS) score in PI. Our results revealed increased instability of intrinsic activity in PI.

show abstract

“…Some of the differences between our results and the other studies were in part due to focusing on different structures, since we only targeted the thalamus, prefrontal cortex, parietal lobe, brain stem, vermis and cerebellar hemispheres, sensorimotor region, auditory cortex, amygdala, and caudate nucleus. These regions have been observed to be affected in patients with insomnia, in addition to several other structures such as the insula or middle frontal gyrus [26,28,45].…”

Section: Sleep Disordersmentioning

confidence: 99%

“…Other fMRI studies comparing functional connectivity in insomnia patients to that in controls revealed an association with the insular cortex, middle frontal gyrus, prefrontal cortex, parietal lobe (particularly the precuneus), and head of the caudate nucleus [26,27]. Additionally, functional connectivity between the cerebellum and various cortical structures is altered in patients with insomnia [28].…”

Section: Introductionmentioning

confidence: 98%

An fMRI Study of the Effects of Vibroacoustic Stimulation on Functional Connectivity in Patients with Insomnia

et al. 2020

View full text Add to dashboard Cite

Background. It is well known that vibratory and auditory stimuli from vehicles such as cars and trains can help induce sleep. More recent literature suggests that specific types of vibratory and acoustic stimulation might help promote sleep, but this has not been tested with neuroimaging. Thus, the purpose of this study was to observe the effects of vibroacoustic stimulation (providing both vibratory and auditory stimuli) on functional connectivity changes in the brain using resting state functional magnetic resonance imaging (rs-fMRI), and compare these changes to improvements in sleep in patients with insomnia. Methods. For this study, 30 patients with insomnia were randomly assigned to receive one month of a vibroacoustic stimulation or be placed in a waitlist control. Patients were evaluated pre- and postprogram with qualitative sleep questionnaires and measurement of sleep duration with an actigraphy watch. In addition, patients underwent rs-fMRI to assess functional connectivity. Results. The results demonstrated that those patients receiving the vibroacoustic stimulation had significant improvements in measured sleep minutes as well as in scores on the Insomnia Severity Index questionnaire. In addition, significant changes were noted in functional connectivity in association with the vermis, cerebellar hemispheres, thalamus, sensorimotor area, nucleus accumbens, and prefrontal cortex. Conclusions. The results of this study show that vibroacoustic stimulation alters the brain’s functional connectivity as well as improves sleep in patients with insomnia.

show abstract

Aberrant Effective Connectivity of the Right Anterior Insula in Primary Insomnia

Cited by 29 publications

References 55 publications

Changes in Brain Function Networks in Patients With Amnestic Mild Cognitive Impairment: A Resting-State fMRI Study

Changes in Brain Function Networks in Patients With Amnestic Mild Cognitive Impairment: A Resting-State fMRI Study

Increased Dynamic Amplitude of Low Frequency Fluctuation in Primary Insomnia

An fMRI Study of the Effects of Vibroacoustic Stimulation on Functional Connectivity in Patients with Insomnia

Contact Info

Product

Resources

About