Aberrant DNA methylation of key genes and Acute Lymphoblastic Leukemia

Rahmani, Mina; Talebi, Mehdi; Hagh, Majid Farshdousti; Feizi, Abbas Ali Hosseinpour; Solali, Saeed

doi:10.1016/j.biopha.2017.11.033

Cited by 32 publications

(24 citation statements)

References 99 publications

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“…Viral infection. One mechanism of leukemogenesis is DNA methylation caused by viral infections (48). The abnormal expression of hematopoietic and proliferation genes persists even after viral clearance.…”

Section: Risk Factorsmentioning

confidence: 99%

Pathogenesis of pediatric B‑cell acute lymphoblastic leukemia: Molecular pathways and disease treatments (Review)

Huang

Liao

et al. 2020

Oncol Lett

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B-cell acute lymphoblastic lymphoma (B-ALL) is a disease found mainly in children and in young adults. BALL is characterized by the rapid proliferation of poorly differentiated lymphoid progenitor cells inside the bone marrow. In the United States, ~4,000 of these patients are diagnosed each year, accounting for ~30% of childhood cancer types. The tumorigenesis of the disease involves a number of abnormal gene expressions (including TEL-AML1, BCR-ABL-1, RAS and PI3K) leading to dysregulated cell cycle. Risk factors of BALL are the history of parvovirus B 19 infection, high birth weight and exposure to environmental toxins. These risk factors can induce abnormal DNA methylation and DNA damages. Treatment procedures are divided into three phases: Induction, consolidation and maintenance. The goal of treatment is complete remission without relapses. Apart from traditional treatments, newly developed approaches include gene targeting therapy, with the aim of wiping out leukemic cells through the inhibition of mitogen-activated protein kinases and via c-Myb inhibition enhancing sensitivity to chemotherapy. To evaluate the efficacy of ongoing treatments, several indicators are currently used. The indicators include the expression levels of microRNAs (miRs) miR-146a, miR-155, miR-181a and miR-195, and soluble interleukin 2 receptor. Multiple drug resistance and levels of glutathione reductase can affect treatment efficacy through the increased efflux of anti-cancer drugs and weakening the effect of chemotherapy through the reduction of intracellular reactive oxygen species. The present review appraised recent studies on BALL regarding its pathogenesis, risk factors, treatments, treatment evaluation and causes of disease relapse. Understanding the mechanisms of BALL initiation and causes of treatment failure can help physicians improve disease management and reduce relapses.

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Section: Risk Factorsmentioning

confidence: 99%

Pathogenesis of pediatric B‑cell acute lymphoblastic leukemia: Molecular pathways and disease treatments (Review)

Huang

Liao

et al. 2020

Oncol Lett

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“…In hematological malignancies (leukemia, lymphomas, and myelomas) mutations in epigenetic modifiers such as JAK2 , DNMT3A , IDH2, or EZH2 are common hallmarks of these diseases [ 32 , 33 , 34 ]. This leads to alterations of the chromatin structure and the silencing of a number of genes such as p15 , RASSF1A [ 33 , 34 ], TET2 , CYP1B1 [ 35 ], PDZD2 , CSDA [ 36 ], DAPK1 , ZAP70 [ 37 ], TERT, or TWIST2 [ 38 ] to promote the growth of cancer cells in these malignancies. The involvement of DNA methylation and histones modifications in cancer is a well-known event that has been long studied in the last decades [ 39 , 40 , 41 , 42 , 43 , 44 ].…”

Section: Implication Of Epigenetics In the Development Of Cancermentioning

confidence: 99%

When Oxidative Stress Meets Epigenetics: Implications in Cancer Development

2020

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Cancer is one of the leading causes of death worldwide and it can affect any part of the organism. It arises as a consequence of the genetic and epigenetic changes that lead to the uncontrolled growth of the cells. The epigenetic machinery can regulate gene expression without altering the DNA sequence, and it comprises methylation of the DNA, histones modifications, and non-coding RNAs. Alterations of these gene-expression regulatory elements can be produced by an imbalance of the intracellular environment, such as the one derived by oxidative stress, to promote cancer development, progression, and resistance to chemotherapeutic treatments. Here we review the current literature on the effect of oxidative stress in the epigenetic machinery, especially over the largely unknown ncRNAs and its consequences toward cancer development and progression.

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“…Indeed, EZH2 is commonly overexpressed in many types of cancers (glioblastoma cancer, acute myeloid leukemia, small cell lung cancer and others), which causes blockage of differentiation and is relevant to unfavorable prognosis (Suva et al 2009;Tanaka et al 2012;Sato et al 2013). Meanwhile anti-cancer genes are usually inhibited by abnormal DNA methylation in both leukemia (Rahmani et al 2018) and solid tumors (Lv et al 2015;Liang and Weisenberger 2017).…”

Section: Epigenetic Mechanisms Associated With Bcscs Self-renewal Andmentioning

confidence: 99%

Prevention of breast cancer by dietary polyphenols—role of cancer stem cells

Mao

2019

Critical Reviews in Food Science and Nutrition

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Breast cancer is a common malignancy with poor prognosis. Cancer cells are heterogeneous and cancer stem cells (CSCs) are primarily responsible for tumor relapse, treatment-resistance and metastasis, so for breast cancer stem cells (BCSCs). Diets are known to be associated with carcinogenesis. Food-derived polyphenols are able to attenuate the formation and virulence of BCSCs, implying that these compounds and their analogs might be promising agents for preventing breast cancer. In the present review, we summarized the origin and surface markers of BCSCs and possible mechanisms responsible for the inhibitory effects of polyphenols on BCSCs. The suppressive effects of common dietary polyphenols against BCSCs, such as curcumin, epigallocatechin gallate (EGCG) and related polyphenolic compounds were further discussed.

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Aberrant DNA methylation of key genes and Acute Lymphoblastic Leukemia

Cited by 32 publications

References 99 publications

Pathogenesis of pediatric B‑cell acute lymphoblastic leukemia: Molecular pathways and disease treatments (Review)

Pathogenesis of pediatric B‑cell acute lymphoblastic leukemia: Molecular pathways and disease treatments (Review)

When Oxidative Stress Meets Epigenetics: Implications in Cancer Development

Prevention of breast cancer by dietary polyphenols—role of cancer stem cells

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