Aberrant DNA methylation distorts developmental trajectories in atypical teratoid/rhabdoid tumors
Meeri Pekkarinen,
Kristiina Nordfors,
Joonas Uusi-Mäkelä
et al.
Abstract:Atypical teratoid/rhabdoid tumors (AT/RTs) are pediatric brain tumors known for their aggressiveness and aberrant but still unresolved epigenetic regulation. To better understand their malignancy, we investigated how AT/RT-specific DNA hypermethylation was associated with gene expression and altered transcription factor binding and how it is linked to upstream regulation. Medulloblastomas, choroid plexus tumors, pluripotent stem cells, and fetal brain were used as references. A part of the genomic regions, whi… Show more
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