Aberrant crypt foci are regionally affected by zinc treatment in a 1,2-dimethylhydrazine induced colon carcinogenesis model

Moulahoum, Hichem; Boumaza, Belkacem Mohamed Amine; Ferrat, Meriem; Nagy, Andras-Laszlo; Olteanu, Diana; Bounaama, Abdelkader; Clichici, Simona

doi:10.1016/j.jtemb.2018.01.009

Cited by 9 publications

(10 citation statements)

References 52 publications

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“…Nrf2, one of the basic leucine zipper transcription factor that can bind to ARE-sequence has been shown to be important for protection against oxidative stress [33]. Many chronic neurological disorders such as multiple sclerosis and neuropathic pain are thought to involve oxidative stress as a factor contributing to the progression of disease [34].…”

Section: Discussionmentioning

confidence: 99%

“…i.p.) on anti-oxidant marker, SOD level was quantified in sciatic nerve, lumbar dorsal spinal cord (L4-L6), hippocampus and prefrontal cortex tissues of day 7, 10 and 14 post PSNL surgery according to the method previously described [33]. The SOD activity was measured by taking Tris-EDTA buffer (50 Mm, pH 8.5), pyrogallol (24 mM) and 10 µ l of sample in a total volume of 0.2 ml.…”

Section: Determination Of Superoxide Dismutase (Sod)mentioning

confidence: 99%

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ECN from <em>Tussilago Farfara</em> Attenuates Neuropathic Pain by Suppressing Oxidative Stress, Inflammatory and Pro-Apoptotic Proteins Expression in Surgical Model

Khan¹,

Khalid²,

Khan³

et al. 2020

Preprint

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7β-(3-ethyl-cis-crotonoyloxy)-1α-(2-methylbutyryloxy)-3,14-dehydro-Z-notonipetranone (ECN), a sesquiterpenoid obtained from a natural origin (Tussilago farfara)has proved to be effective in minimizing various side effects associated with opioids and nonsteroidal anti-inflammatory drugs. The current study focused on investigating the effects of ECN on neuropathic pain induced by partial sciatic nerve ligation (PSNL) by mainly focusing on oxidative stress, inflammatory and apoptotic proteins expression in mice. Neuropathic pain was induced in mice by PSNL surgery performed on day 1 and ECN (1 and 10 mg/kg, i.p.), was administered once daily for 11 days, starting from the third day after surgery. ECN post-treatment was found to reduce hyperalgesia and allodynia in a dose dependent manner. ECN significantly reversed the severity of neuropathic pain by improving distress symptoms and survival rate. ECN remarkably reversed the histopathological abnormalities associated with oxidative stress, apoptosis and inflammation. Furthermore, ECN prevented the suppression of antioxidants (glutathione, glutathione-S-transferase, catalase, superoxide dismutase, NF-E2-related factor-2 (Nrf2), hemeoxygenase-1 and NAD(P)H: quinone oxidoreductase) by PSNL. Moreover, pro-inflammatory cytokines (tumor necrotic factor alpha, interleukin 1 beta, interleukin 6, cyclooxygenase-2 and inducible nitric oxide synthase) expression was reduced by ECN administration. Treatment with ECN was successful in reducing caspase-3 level consistent with the observed modulation of pro-apoptotic proteins. Additionally, ECN showed protective effect on the lipid content of myelin sheath as evident from FTIR spectroscopy which showed the shift of lipid component bands to higher values. Thus, anti-neuropathic potential of ECN might be due to inhibition of oxidative stress, inflammatory mediators and pro-apoptotic proteins.

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Section: Discussionmentioning

confidence: 99%

Section: Determination Of Superoxide Dismutase (Sod)mentioning

confidence: 99%

ECN from <em>Tussilago Farfara</em> Attenuates Neuropathic Pain by Suppressing Oxidative Stress, Inflammatory and Pro-Apoptotic Proteins Expression in Surgical Model

Khan¹,

Khalid²,

Khan³

et al. 2020

Preprint

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“…These differential toxic effects could be explained by the focal inoculation of acetic acid in the distal colon. However, distal and proximal colons have multiple biological specificities that may explain the differential degree in inflammatory injuries including embryogenic origin, histological architecture, absorbing functions, gene expression patterns, and immune response markers (Amrouche-Mekkioui and Djerdjouri 2012; Moulahoum et al 2018). GdCl 3 prevented redox imbalance throughout the whole colon.…”

Section: Discussionmentioning

confidence: 99%

Gadolinium chloride attenuates acetic acid-evoked colitis in mice by reducing neutrophil infiltration and pro-oxidative enzyme activity

Ferrat

Moulahoum

Boumaza

et al. 2018

Naunyn-Schmiedeberg's Arch Pharmacol

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This study investigated the potential of gadolinium chloride (GdCl 3 ), an inhibitor of kupffer cells on the myeloperoxidase (MPO) function, both in vivo on colon inflammation model and in vitro on thioglycollate-elicited peritoneal neutrophils. Colon inflammation was induced in mice (n = 7) by 4% acetic acid (AA) enema. GdCl 3 (10 mg/kg) treatment was given 24 h before AA challenge. Clinical changes during the protocol were scored. Colons were segmented into distal and proximal parts for histological and biochemical assessment. Furthermore, myeloperoxidase (MPO) enzymes were extracted and analyzed by western blot. Short-term GdCl 3 treatment inhibited dose-dependently superoxide anion (O 2 •− ), alkaline phosphatase (ALP), and MPO release and promoted neutrophil apoptosis. In vivo, low-dose GdCl 3 improved colitis scores and inhibited acute phagocyte recruitment and colon damage within the mucosa as revealed by the decrease in MPO, nitric oxide (NO), and malondialdehyde (MDA) levels. At the same time, GdCl 3 restored catalase (CAT), superoxide dismutase (SOD) activities, and reduced glutathione (GSH) levels, thus reversing the MDA/GSH ratio in both distal and proximal colons. Compared to proximal, distal colon was more altered and displayed higher pathological manifestations. Lastly, the induction of apoptosis and regulation of the major nitrosative and oxidative functions of neutrophils by GdCl 3 suggests its consideration as a beneficial tool in attenuating colon inflammation.

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“…From the results, M. loriformis extract demonstrated antimutagenic activity against the tested heterocyclic amines in dose-dependent manner and decreased the number of ACF (with more than 3 aberrant crypts per focus) formation. ACF with more than three crypts per focus was reported to be associated with precolorectal cancer development [10,54]. us, treatment with Evidence-Based Complementary and Alternative Medicine M. loriformis extract could prevent azoxymethane-induced aberrant crypt foci by acting as a suppressing or blocking agent in the progression of carcinogenesis.…”

Section: Antimutagenicitymentioning

confidence: 99%

Murdannia loriformis: A Review of Ethnomedicinal Uses, Phytochemistry, Pharmacology, Contemporary Application, and Toxicology

Sulaiman

Mohamad

Ahmed

2021

Evidence-Based Complementary and Alternative Medicine

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This review provides an updated and comprehensive overview on the ethnomedicinal use, phytochemistry, pharmacology, and toxicology of M. loriformis. Phytochemical analysis of M. loriformis revealed that it is composed of phenolics, flavonoids, condensed tannins, chlorophylls, alkaloids, and steroids. Numerous compounds including syringic acid, ß-O-D-glucopyranosyl-2-(2′-hydroxy-Z-6′-enecosamide) sphingosine, isovitexin, and 3β-O-D-glucopyranosyl-24ξ-ethylcholest-5-ene have been identified and isolated from this plant species. The present review attempts to bridge the gap between traditional use and pharmacological studies of M. loriformis while improving their existing therapeutic agents and product applications based on this plant.

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Aberrant crypt foci are regionally affected by zinc treatment in a 1,2-dimethylhydrazine induced colon carcinogenesis model

Cited by 9 publications

References 52 publications

ECN from <em>Tussilago Farfara</em> Attenuates Neuropathic Pain by Suppressing Oxidative Stress, Inflammatory and Pro-Apoptotic Proteins Expression in Surgical Model

ECN from <em>Tussilago Farfara</em> Attenuates Neuropathic Pain by Suppressing Oxidative Stress, Inflammatory and Pro-Apoptotic Proteins Expression in Surgical Model

Gadolinium chloride attenuates acetic acid-evoked colitis in mice by reducing neutrophil infiltration and pro-oxidative enzyme activity

Murdannia loriformis: A Review of Ethnomedicinal Uses, Phytochemistry, Pharmacology, Contemporary Application, and Toxicology

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