Aberrant craniopharyngeal structures within the neurohypophysis of rats

Schaetti, P.; Argentino-Storino, Alberta; Heinrichs, Martin; Mirea, Dumitru; Popp, Andreas; Karbe, E.

doi:10.1016/s0940-2993(11)80299-x

Cited by 21 publications

(23 citation statements)

References 18 publications

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“…Mackenzie and Boorman described the abnormality in the pars intermedia and pars nervosa of the pituitary gland in Fischer rats to represent the persistent remnant of the Rathke's pouch or its proliferative lesions (10). Schaetti et al also observed aberrant craniopharyngeal structures of neurohypophysis, similar to those reported by Mackenzie and Boorman (10), in 17 Sprague-Dawley and Wistar rats (13). Karbe and Ernst reported such lesions as &dquo;craniopharyngeal derivatives&dquo; in rats and also in Syrian hamsters, and they considered that these lesions were a developmental aberration of craniopharyngeal ducts (6).…”

Section: Introductionsupporting

confidence: 70%

“…It has been reported that craniopharyngeal derivatives are characterized by the aberrant epithelial nests, consisting of tubular or acinar glandular structures in the neurohypophysis in rats (6,10,13). These derivatives were frequently associated with Rathke's cleft cysts (Figure 7) and consisted of 3 different structures: acinar, tubular, and fusiform cell (13) (Figure 8).…”

Section: Discussionmentioning

confidence: 97%

“…These derivatives were frequently associated with Rathke's cleft cysts (Figure 7) and consisted of 3 different structures: acinar, tubular, and fusiform cell (13) (Figure 8). …”

Section: Discussionmentioning

confidence: 99%

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Morphogenesis of Craniopharyngeal Derivatives in the Neurohypophysis of Fisher 344 Rats: Abnormally Developed Epithelial Tissues Including Parotid Glands Derived from the Stomatodeum

Iwata¹,

Hosoi²,

Miyajima³

et al. 2000

Toxicol Pathol

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Morphogenesis of craniopharyngeal derivatives of the neurohypophysis found in 14 Fischer 344 (F344) rats was studied. The incidence of the craniopharyngeal derivatives was 0.17% in male (7 out of 4,200) and 0.16% in female (7 out of 4,450) F344 rats. Neither a sexrelated difference in their incidence nor a strain-related difference in their morphological features was observed. Craniopharyngeal derivatives were composed of aberrant epithelial structures consisting of serous acinar and tubular and fusiform cell structures, and most of these derivatives were associated with Rathke's cleft cysts, which are suggestive of a congenital background. The acinar structures were positive for periodic acid-Schiff reaction and negative for Alcian blue stain. Immunohistochemically, cells forming these structures were positive for cytokeratin, and basal cells of the acinar or tubular structures and some of the fusiform cells showed positive staining for alpha-smooth muscle actin. Electron microscopically, these spindle-shaped basal cells had intracytoplasmic myofilaments with focal density in their cytoplasm, and they were regarded to be myoepithelial cells. These findings strongly indicate that the craniopharyngeal derivatives are not a neoplastic lesion but rather are a developmental aberration derived from the stomatodeum, which is known to be the origin of both nasal and oral epithelial tissues, including the parotid glands, other than Rathke's pouch.

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Section: Introductionsupporting

confidence: 70%

Section: Discussionmentioning

confidence: 97%

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Morphogenesis of Craniopharyngeal Derivatives in the Neurohypophysis of Fisher 344 Rats: Abnormally Developed Epithelial Tissues Including Parotid Glands Derived from the Stomatodeum

Iwata¹,

Hosoi²,

Miyajima³

et al. 2000

Toxicol Pathol

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“…The authors found evidence of epithelial craniopharyngeal derivatives in approximately 0.16% of rats, and they suggested developmental rather than neoplastic origins of RCCs and related cystic epithelial lesions. Similarly, Schaetti and colleagues 94 examined pituitary specimens in rats and reported finding epithelial craniopharyngeal derivatives consisting of cuboidal or columnar epithelium with goblet cells or stratified squamous epithelium. The authors of this study supported a heterotopic, nonneoplastic origin for many of these various epithelial cystic masses as well.…”

Section: Evidence Lending Support To a Common Ectodermal Origin Of Cymentioning

confidence: 95%

Craniopharyngioma and other cystic epithelial lesions of the sellar region: a review of clinical, imaging, and histopathological relationships

Zada¹,

Lin²,

Ojerholm³

et al. 2010

FOC

229

182

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Object Cystic epithelial masses of the sellar and parasellar region may be difficult to differentiate on a clinical, imaging, or even histopathological basis. The authors review the developmental relationships and differentiating features of various epithelial lesions of the sellar region. Methods The authors performed a review of the literature to identify previous studies describing the etiological relationships and differentiating features of various cystic sellar lesions, including craniopharyngioma (CP), Rathke cleft cyst, xanthogranuloma, and dermoid and epidermoid cysts. Results There is significant evidence in the literature to support a common ectodermal origin of selected sellar and suprasellar cystic lesions, which may account for the overlap of features and transitional states observed in some cases. Research obtained from animal studies and reports of transitional cystic epithelial masses or lesions crossing over from typical to more aggressive pathological subtypes have collectively provided a solid foundation for this theory. Histological features that signify transitional entities beyond simple benign Rathke cleft cysts include squamous metaplasia, stratified squamous epithelium, and ciliated or mucinous goblet cells in squamous-papillary CPs. Several studies have identified key clinical, imaging, and histopathological features that can be used in the differentiation of these lesions. Conclusions The pattern of embryological formation of the hypothalamic-pituitary axis plays a major role in its propensity for developing cystic epithelial lesions. Subsequent inflammatory, metaplastic, and neoplastic processes may promote further progression along the pathological continuum, ranging from benign epithelial cysts to aggressive neoplastic cystic CPs. Selected clinical, imaging, and histopathological features can be used collectively to help differentiate these lesions and assign a formal diagnosis, thus accurately guiding further treatment.

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“…Cystic epithelial lesions may comprise varying entities along a continuum of pathology, with the benign RCCs at one end of the spectrum and at the other end are craniopharyngiomas, which are neoplastic lesions arising from squamous epithelial cell rests occurring in the region of the remnant hypophyseal/pharyngeal duct [33]. The papillary subtype of craniopharyngioma is thought to arise from metaplasia of the squamous epithelial cell rests found in the adenohypophysis and infundibulum [34], but studies examining pituitary specimens in rats reported finding epithelial craniopharyngeal derivatives consisting of cuboidal or columnar epithelium with goblet cells or stratified squamous epithelium [35]. Furthermore, other cases of ciliated epithelial cells or mucin-containing goblet cells occurring in squamous-papillary craniopharyngiomas have been reported to further support the theory for a common ectodermal origin between RCCs and craniopharyngiomas [36][37][38].…”

Section: Casementioning

confidence: 99%

Two collision sellar lesions: Rathke's cleft cyst with non-functional pituitary adenoma and Rathke's cleft cyst with plurihormonal adenoma

Sarmiento¹,

Wi²,

Piao³

et al. 2013

J Cancer Ther Res

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Aberrant craniopharyngeal structures within the neurohypophysis of rats

Cited by 21 publications

References 18 publications

Morphogenesis of Craniopharyngeal Derivatives in the Neurohypophysis of Fisher 344 Rats: Abnormally Developed Epithelial Tissues Including Parotid Glands Derived from the Stomatodeum

Morphogenesis of Craniopharyngeal Derivatives in the Neurohypophysis of Fisher 344 Rats: Abnormally Developed Epithelial Tissues Including Parotid Glands Derived from the Stomatodeum

Craniopharyngioma and other cystic epithelial lesions of the sellar region: a review of clinical, imaging, and histopathological relationships

Two collision sellar lesions: Rathke's cleft cyst with non-functional pituitary adenoma and Rathke's cleft cyst with plurihormonal adenoma

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