Aberrant Cholesterol Metabolism in Ovarian Cancer: Identification of Novel Therapeutic Targets

He, Jiangnan; Siu, Michelle K.Y.; Ngan, Hextan Y. S.; Chan, Ki

doi:10.3389/fonc.2021.738177

Cited by 15 publications

(22 citation statements)

References 120 publications

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“…Pyroptosis-restricting metabolic changes are necessary for cancer cell survival. 209 Li et al 210 found that IL-1α and IL-1β were overexpressed in a 1992 investigation on epithelial tumor cell lines and tumor cells derived from the ascitic fluid of ovarian cancer patients. In ovarian cancer cells with the 185delAG founder mutation in the breast cancer susceptibility gene 1, there was an increase in active IL-1 and elevation in caspase 1 cleavage mediated by inflammasome.…”

Section: Ovarian Cancermentioning

confidence: 99%

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Pyroptosis and inflammasomes in cancer and inflammation

Wang,

Hua,

Bao

et al. 2023

MedComm

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Nonprogrammed cell death (NPCD) and programmed cell death (PCD) are two types of cell death. Cell death is significantly linked to tumor development, medication resistance, cancer recurrence, and metastatic dissemination. Therefore, a comprehensive understanding of cell death is essential for the treatment of cancer. Pyroptosis is a kind of PCD distinct from autophagy and apoptosis in terms of the structure and function of cells. The defining features of pyroptosis include the release of an inflammatory cascade reaction and the expulsion of lysosomes, inflammatory mediators, and other cellular substances from within the cell. Additionally, it displays variations in osmotic pressure both within and outside the cell. Pyroptosis, as evidenced by a growing body of research, is critical for controlling the development of inflammatory diseases and cancer. In this paper, we reviewed the current level of knowledge on the mechanism of pyroptosis and inflammasomes and their connection to cancer and inflammatory diseases. This article presents a theoretical framework for investigating the potential of therapeutic targets in cancer and inflammatory diseases, overcoming medication resistance, establishing nanomedicines associated with pyroptosis, and developing risk prediction models in refractory cancer. Given the link between pyroptosis and the emergence of cancer and inflammatory diseases, pyroptosis‐targeted treatments may be a cutting‐edge treatment strategy.

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Section: Ovarian Cancermentioning

confidence: 99%

“…This imbalance is usual in cancers, particularly ovarian cancer. Pyroptosis‐restricting metabolic changes are necessary for cancer cell survival 209 . Li et al 210 .…”

Section: Pyroptosis and Inflammasomes In Cancermentioning

confidence: 99%

Pyroptosis and inflammasomes in cancer and inflammation

Wang,

Hua,

Bao

et al. 2023

MedComm

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“…Low-grade plasmacytomas, endometrioid carcinomas, clear cell carcinomas, and mucinous carcinomas are examples of type I tumors. High-grade plasmacytomas and undifferentiated carcinomas are examples of type II tumors ( He et al, 2021 ). High-grade plasmacytomas and undifferentiated carcinomas are the two main type II tumors.…”

Section: Structure and Function Of Npc1l1mentioning

confidence: 99%

The role of NPC1L1 in cancer

et al. 2022

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Lipid metabolism appears to play significant roles in the development of cancer. Numerous studies have shown that the evolution of malignancies, including breast, prostate, and colorectal cancers, involves cholesterol in a profound manner. A crucial part in the intestinal absorption of cholesterol is played by Niemann–Pick C1-like 1 (NPC1L1), a cholesterol transporter protein that is widely expressed in the small intestine and liver. The importance of NPC1L1 in tumor prognosis has been demonstrated in investigations in the interim. NPC1L1 also has the potential to develop into a new therapeutic target and a cancer marker. There is, however, no comprehensive review that summarizes NPC1L1’s function in cancer. To this end, we outlined NPC1L1’s functions in carcinogenesis and treatment, along with resources that can be used to further comprehend the connection between NPC1L1 and tumors.

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“…Given that this imbalance is common in cancers (82), including ovarian cancer, the hypothesis is that there is a greater difficulty in pore formation, because of the higher levels of phosphatidylinositide and cholesterol in cell membrane, which makes the cancer cells viable (83). Cholesterol metabolism is altered in ovarian cancer (84). Thus, pyroptosis, impaired by metabolic alterations, plays a crucial role in the overall survival of ovarian cancer cells.…”

Section: Gsdmmentioning

confidence: 99%

The Role of Inflammasomes in Ovarian Cancer

Martins¹,

Ribeiro²,

Pimenta³

et al. 2022

Ovarian Cancer

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Ovarian cancer is a leading cause of gynecological cancer-related deaths in women worldwide, mainly because of its late diagnosis. In many cases, at the time of diagnosis, the cancer cells are chemoresistant and invasive. Early detection of the disease is crucial for a clinically satisfactory outcome, treatment planning, and a better prognosis. The development of new strategies for early detection may contribute to improving overall survival in patients. Inflammation is an established factor in carcinogenesis, and protein complexes named inflammasomes, along with their components and subproducts, such as interleukins and other molecules, have been explored as promising potential Note to the reader: This chapter is part of the book Ovarian Cancer

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Aberrant Cholesterol Metabolism in Ovarian Cancer: Identification of Novel Therapeutic Targets

Cited by 15 publications

References 120 publications

Pyroptosis and inflammasomes in cancer and inflammation

Pyroptosis and inflammasomes in cancer and inflammation

The role of NPC1L1 in cancer

The Role of Inflammasomes in Ovarian Cancer

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