Aberrant Changes in Cortical Complexity in Right-Onset Versus Left-Onset Parkinson’s Disease in Early-Stage

Abstract

There is increasing evidence to show that motor symptom lateralization in Parkinson’s disease (PD) is linked to non-motor features, progression, and prognosis of the disease. However, few studies have reported the difference in cortical complexity between patients with left-onset of PD (LPD) and right-onset of PD (RPD). This study aimed to investigate the differences in the cortical complexity between early-stage LPD and RPD. High-resolution T1-weighted magnetic resonance images of the brain were acquired in 24 patients with LPD, 34 patients with RPD, and 37 age- and sex-matched healthy controls (HCs). Cortical complexity including gyrification index, fractal dimension (FD), and sulcal depth was analyzed using surface-based morphometry via CAT12/SPM12. Familywise error (FWE) peak-level correction at p < 0.05 was performed for significance testing. In patients with RPD, we found decreased mean FD and mean sulcal depth in the banks of the left superior temporal sulcus (STS) compared with LPD and HCs. The mean FD in the left superior temporal gyrus (STG) was decreased in RPD compared with HCs. However, in patients with LPD, we did not identify significantly abnormal cortical complex change compared with HCs. Moreover, we observed that the mean FD in STG was negatively correlated with the 17-item Hamilton Depression Scale (HAMD) among the three groups. Our findings support the specific influence of asymmetrical motor symptoms in cortical complexity in early-stage PD and reveal that the banks of left STS and left STG might play a crucial role in RPD.

Left middle frontal gyrus (MFG) thickness in Parkinson’s disease patients is associated with abnormal audiovisual conflict

“…In addition, previous studies found that PD patients had a significantly higher Regional Homogeneity (ReHo) value in the precentral regions compared with HC group, which might be related to cognitive and behavioral dysfunction of PD patients (Shen & Xu, 2022). Bankssts was found to be associated with the lateralization of motor symptoms, and might play a key role in right-onset of PD (Zhang et al, 2021).…”

Cortical Complexity Alterations in Motor Subtypes of Parkinson's Disease: A Surface-Based Morphometry Analysis of Fractal Dimension

“…This alteration in the cortical fractal structure may be an indirect consequence of damage sustained by the brain's subcortical regions. Previous studies noted altered cortical complexity in PD patients [36][37][38]. Clinically, the symptoms manifested by PD patients could be heterogeneous [3].…”

“…The study found widespread FD reductions in PD patients compared to HCs but no significant differences in GI. Zhang et al [37] studied differences in cortical complexity between early-stage right-onset and left-onset PD and HCs. They found that right-onset PD patients had decreased FD in the left superior temporal cortex compared to HCs.…”

Perception, Not Response: The Causes of Abnormal Audiovisual Conflict in Parkinson's disease patients

“…In addition, previous studies found that PD patients had a significantly higher Regional Homogeneity (ReHo) value in the precentral regions compared with HC group, which might be related to cognitive and behavioral dysfunction of PD patients 24 . Bankssts was found to be associated with the lateralization of motor symptoms, and might play a key role in right-onset of PD 25 .…”