Aberrant cerebral blood flow responses during cognition: Implications for the understanding of cognitive deficits in fibromyalgia.

Montoro, Casandra I.; Duschek, Stefan; Guevara, Cristina Muñoz Ladrón de; Fernández-Serrano, María José; Paso, Gustavo A. Reyes del

doi:10.1037/neu0000138

Cited by 58 publications

(78 citation statements)

References 46 publications

(94 reference statements)

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“…However, the degree of activation was lower in FMS patients compared to healthy controls, and this difference was largely accounted for by the depressive symptom scores [196]. Consistent with the observation that anxiety ratings were associated with the degree of activation in certain brain areas during working memory tasks [196], anxiety symptoms have been associated with various cognitive variables, including delayed recall, memory, and processing speed [182,203]. However, others failed to find any correlation with performance on go/no-go tasks [191], and patients with anxiety disorders actually performed better on a mental arithmetic task than those without such disorders [192].…”

Section: Cognitive Complaints/fibrofogmentioning

confidence: 56%

“…Daytime sleepiness correlated with a lower rate of correct responses during a mental arithmetic task in the patient group [203], but was not significantly associated with performance on a go/no-go task [191]. Sleep quality would also be expected to affect cognition and was correlated with perceived memory deficits [213].…”

Section: Cognitive Complaints/fibrofogmentioning

confidence: 95%

“…Significant decrements in processing speed have been documented in FMS patients using a variety of tests [186,192,202,203], even though normal results have also been obtained with certain tasks [204,205], and occasionally, FMS patients perform even better than controls [202]. However, it is often not possible to clearly distinguish between reduced mental processing speed, decreased psychomotor speed, or a combination of both [206].…”

Section: Cognitive Complaints/fibrofogmentioning

confidence: 99%

“…Pain intensity has been identified as an important determinant of a variety of aspects of objectively assessed dyscognition in FMS [187,200,203] and may even account almost entirely for the deficits in processing speed and attention observed in patients with FMS [192,194]. However, the effect of pain may be task-and domain-specific.…”

Section: Cognitive Complaints/fibrofogmentioning

confidence: 99%

“…This highlights the importance of accounting for effort, which is not routinely done. Nonetheless, there is little indication overall that low effort or simulation accounts for cognitive impairments in the majority of FMS patients [195,200,203]. The fact that FMS patients and healthy controls often do not differ in the accuracy of their performance on cognitive tasks (even if the response times are longer in the patient group) also does not support decreased effort [186,192,227].…”

Section: Cognitive Complaints/fibrofogmentioning

confidence: 99%

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Fibromyalgia: A Critical and Comprehensive Review

Borchers

Gershwin

2015

Clinic Rev Allerg Immunol

225

217

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Fibromyalgia is a disorder that is part of a spectrum of syndromes that lack precise classification. It is often considered as part of the global overview of functional somatic syndromes that are otherwise medically unexplained or part of a somatization disorder. Patients with fibromyalgia share symptoms with other functional somatic problems, including issues of myalgias, arthralgias, fatigue and sleep disturbances. Indeed, there is often diagnostic and classification overlap for the case definitions of a variety of somatization disorders. Fibromyalgia, however, is a critically important syndrome for physicians and scientists to be aware of. Patients should be taken very seriously and provided optimal care. Although inflammatory, infectious, and autoimmune disorders have all been ascribed to be etiological events in the development of fibromyalgia, there is very little data to support such a thesis. Many of these disorders are associated with depression and anxiety and may even be part of what has been sometimes called affected spectrum disorders. There is no evidence that physical trauma, i.e., automobile accidents, is associated with the development or exacerbation of fibromyalgia. Treatment should be placed on education, patient support, physical therapy, nutrition, and exercise, including the use of drugs that are approved for the treatment of fibromyalgia. Treatment should not include opiates and patients should not become poly pharmacies in which the treatment itself can lead to significant morbidities. Patients with fibromyalgia are living and not dying of this disorder and positive outlooks and family support are key elements in the management of patients.

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Section: Cognitive Complaints/fibrofogmentioning

confidence: 56%

Section: Cognitive Complaints/fibrofogmentioning

confidence: 95%

Section: Cognitive Complaints/fibrofogmentioning

confidence: 99%

Section: Cognitive Complaints/fibrofogmentioning

confidence: 99%

Section: Cognitive Complaints/fibrofogmentioning

confidence: 99%

See 3 more Smart Citations

Fibromyalgia: A Critical and Comprehensive Review

Borchers

Gershwin

2015

Clinic Rev Allerg Immunol

225

217

View full text Add to dashboard Cite

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Fibrofog in Daily Life: An Examination of Ambulatory Subjective and Objective Cognitive Function in Fibromyalgia

Kratz

Whibley

Kim

et al. 2020

Arthritis Care & Research

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Objective. Perceived cognitive dysfunction in fibromyalgia (FM), "fibrofog," is common. Prior laboratory-based studies have limited our understanding of cognitive function in FM in daily life. The objective of this study was to explore levels of subjective and objective cognitive functioning and the association between subjective and objective aspects of cognition in people with and without FM in the lived environment. Methods. Participants (n = 50 adults with FM; n = 50 adults without FM, matched for age, sex, and education) completed baseline measures of subjective and objective cognitive functioning (NIH Toolbox). They also completed ecological momentary assessments of cognitive clarity and speed, and tests of processing speed and working memory, via a smart phone app, 5 times/day for 8 days. Results. On baseline objective measures, the FM group demonstrated poorer cognitive functioning across 3 NIH Toolbox tests. There were no strong correlations between subjective and objective cognitive functioning in both the FM and control groups. In the lived environment, the FM group demonstrated poorer subjective cognition and objective working memory; groups did not differ on processing speed. Momentary ratings of subjective cognitive dysfunction were significantly related to changes in objective processing speed but not working memory, with no group differences. Conclusion. Findings indicate worse laboratory-based and ambulatory subjective and objective cognitive function for those individuals with FM compared to those without FM. Similar associations between measures of subjective and objective cognitive functioning for the groups suggest that individuals with FM are not overstating cognitive difficulties. Future research examining contributors to ambulatory fibrofog is warranted.

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The frequency of psychiatric disorder co‐morbidities in patients with fibromyalgia: A cross‐sectional study in Iran

et al. 2023

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Aim This study aimed to investigate psychiatric disorders in Iranian female patients with fibromyalgia (FM). Design Female patients, newly diagnosed with FM, were interviewed by a psychiatrist for psychiatric assessments during a 2‐year period. Methods The diagnosis of the psychiatric disorders was based on the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM‐5), and sleep quality was evaluated using the Pittsburgh Sleep Quality Index (PSQI). Results In total, 159 patients with the mean age of 42.15 ± 9.89 were recruited in this study. Over 92% of the cases were also diagnosed with at least one type of psychiatric disorder. Sleep disorders (SDs, 90.57%), mood disorders (MDs, 52.83%), personality disorders (PDs, 40.25%) and anxiety disorders (ADs, 16.98%) were the most prevalent diagnoses among these patients. The logistic regression results correspondingly showed that suffering from Cluster‐B PDs was associated with a higher prevalence rate of somatic symptom disorders (SSDs), with a p‐value of 0.019 and an odds ratio (OR) of 2.7.

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Aberrant cerebral blood flow responses during cognition: Implications for the understanding of cognitive deficits in fibromyalgia.

Abstract: Cognitive impairment in FMS is associated with alterations in cerebral blood flow responses during cognitive processing. These results suggest a potential physiological pathway through which psychosocial and clinical factors may affect cognition.

Cited by 58 publications

References 46 publications

Fibromyalgia: A Critical and Comprehensive Review

Fibromyalgia: A Critical and Comprehensive Review

Fibrofog in Daily Life: An Examination of Ambulatory Subjective and Objective Cognitive Function in Fibromyalgia

The frequency of psychiatric disorder co‐morbidities in patients with fibromyalgia: A cross‐sectional study in Iran

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