Aberrant Brain Regional Homogeneity and Functional Connectivity of Entorhinal Cortex in Vascular Mild Cognitive Impairment: A Resting-State Functional MRI Study

Zuo, Meimei; Xu, Yi; Zhang, Xiaomin; Li, Man; Jia, Xiuqin; Niu, Jinliang; Li, Dongfang; Han, Yanqing; Yang, Yanhui

doi:10.3389/fneur.2018.01177

Cited by 20 publications

(18 citation statements)

References 36 publications

(38 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This is consistent with the notion that the dorsolateral prefrontal circuit is involved mainly in executive function [47,48]. Using fMRI, decreased ALFF and FC in the frontal lobe have been repeatedly reported in VaMCI [49][50][51][52]. In addition, orbitofrontal syndromes, such as disinhibition and decreased social behavior, are more frequent in VaMCI than in aMCI.…”

Section: Neural Plasticitysupporting

confidence: 86%

Distinctive Alterations of Functional Connectivity Strength between Vascular and Amnestic Mild Cognitive Impairment

Gao

Jia

et al. 2021

Neural Plasticity

Self Cite

View full text Add to dashboard Cite

Widespread structural and functional alterations have been reported in the two highly prevalent mild cognitive impairment (MCI) subtypes, amnestic MCI (aMCI) and vascular MCI (VaMCI). However, the changing pattern in functional connectivity strength (FCS) remains largely unclear. The aim of the present study is to detect the differences of FCS and to further explore the detailed resting-state functional connectivity (FC) alterations among VaMCI subjects, aMCI subjects, and healthy controls (HC). Twenty-six aMCI subjects, 31 VaMCI participants, and 36 HC participants underwent cognitive assessments and resting-state functional MRI scans. At first, one-way ANCOVA and post hoc analysis indicated significant decreased FCS in the left middle temporal gyrus (MTG) in aMCI and VaMCI groups compared to HC, especially in the VaMCI group. Then, we selected the left MTG as a seed to further explore the detailed resting-state FC alterations among the three groups, and the results indicated that FC between the left MTG and some frontal brain regions were significantly decreased mainly in VaMCI. Finally, partial correlation analysis revealed that the FC values between the left MTG and left inferior frontal gyrus were positively correlated with the cognitive performance episodic memory and negatively related to the living status. The present study demonstrated that different FCS alterations existed in aMCI and VaMCI. These findings may provide a novel insight into the understanding of pathophysiological mechanisms underlying different MCI subtypes.

show abstract

Section: Neural Plasticitysupporting

confidence: 86%

Distinctive Alterations of Functional Connectivity Strength between Vascular and Amnestic Mild Cognitive Impairment

Gao

Jia

et al. 2021

Neural Plasticity

Self Cite

View full text Add to dashboard Cite

show abstract

“…In addition to moderate and severe (Monti et al 2013;Spielberg et al 2015). And hippocampal neurodegeration in patients with mTBI linked to cognitive function decline is reported by previous studies (Monti et al 2013;Zuo et al 2018). However, the present analysis did not show any functional connectivity between the insula and hippocampus was significantly correlated with the MoCA score.…”

Section: Insula-hippocampal Connectivitycontrasting

confidence: 50%

Functional connectivity dysfunction of insular subdivisions in cognitive impairment after acute mild traumatic brain injury

Chen

et al. 2020

Brain Imaging and Behavior

View full text Add to dashboard Cite

Purpose This study aimed to investigate the early functional connectivity alterations between insula subdivisions and other cortical regions in patients with acute mild traumatic brain injury (mTBI) and subsequently to explore the relationship between functional connectivity changes of insula subdivisions with other cortical regions and cognitive function. Methods Fifty-three mTBI patients and 37 age-, gender-and education level-matched healthy controls were included in this study. All participants obtained resting state functional magnetic resonance imaging (rs-fMRI) and clinical and neuropsychological evaluations (Montreal cognitive assessment, MoCA) at the acute stage. Functional connectivity alterations of insula subdivisions and correlations with MoCA were further explored by seed-voxel functional connectivity. Results Compared with healthy controls, patients with acute mTBI showed significantly decreased functional connectivity between the L-vAI and the left middle temporal gyrus and right superior frontal gyrus and significantly decreased functional connectivity between the R-vAI and the right middle frontal gyrus and right hippocampus. While significantly decreased functional connectivity were observed between the L-dAI and the right superior frontal gyrus. In addition, significantly increased functional connectivity was observed between the R-PI and the left inferior frontal gyrus. Furthermore, the mTBI group demonstrated positive correlations between performances in orientation and insula and middle temporal gyrus and superior frontal gyrus and middle frontal gyrus functional connectivities. Abstraction scores for mTBI patients positively correlated with functional connectivity between insula and middle frontal gyrus. Conclusions The present study demonstrated functional connectivity dysfunction of insula subdivisions and correlations between these alterations and cognitive performance, which provide a novel insight into the neurophysiological mechanism of cognitive impairment in patients with mTBI at the acute stage.

show abstract

“…A previous study investigating EC’s FC (termed as “EC-FC”) in patients with vascular MCI (VaMCI) revealed that VaMCI subjects showed a significantly decreased FC between the right EC and the right inferior frontal gyrus, right middle frontal gyrus, bilateral precentral gyri, right postcentral gyrus, and right superior parietal lobule. These results suggest that the EC-FC changes and their correlations with neuropsychological measures may aid in the early diagnosis of cognitive decline in the aging process ( Zuo et al, 2018 ). EC, as a crucial cognitive function-related region, together with its associated large-scale human brain cognitive FC network, could play an important role in normative and pathologic aging and may serve as an important imaging marker for therapeutic effect on aging.…”

Section: Introductionmentioning

confidence: 93%

Different Modulatory Effects of Cognitive Training and Aerobic Exercise on Resting State Functional Connectivity of Entorhinal Cortex in Community-Dwelling Older Adults

Cao

et al. 2021

Front. Aging Neurosci.

View full text Add to dashboard Cite

The entorhinal cortex (EC) plays an essential role in age-related cognitive decline. However, the effect of functional connectivity (FC) changes between EC and other cerebral cortices on cognitive function remains unclear. The aim of this study was to explore the modulation of two interventions (cognitive training and aerobic exercise) on EC-FC in community-dwelling older adults. In total, 94 healthy older adults aged between 65 and 75 years were assigned to either the cognitive training or aerobic exercise group to receive 24 sessions over 12 weeks, or to a control group. Resting-state functional magnetic resonance imaging was performed at both baseline and 12-month follow-up. Compared to the cognitive training group, the aerobic exercise group showed greater EC-FC in the bilateral middle temporal gyrus, right supramarginal gyrus, left angular gyrus, and right postcentral gyrus. Compared to the control group, the cognitive training group had a decreased EC-FC in the right hippocampus, right middle temporal gyrus, left angular gyrus, and right postcentral gyrus and an increased EC-FC in the bilateral pallidum, while the aerobic exercise group showed increased EC-FC between the right medial prefrontal cortex(mPFC), bilateral pallidum, and right precuneus. Baseline EC-FC in the mPFC was positively correlated with the visuospatial/constructional index score of the Repeatable Battery for the Assessment of Neuropsychological Status. In the cognitive training group, EC-FC value changes in the right hippocampus were negatively correlated with changes in the RBANS delayed memory index score, while in the aerobic exercise group, EC-FC value changes in the left angular gyrus were positively correlated with changes in the RBANS attention index score. These findings support the hypothesis that both cognitive training and aerobic exercise can modulate EC-FC in aging populations but through different neural pathways.

show abstract

Aberrant Brain Regional Homogeneity and Functional Connectivity of Entorhinal Cortex in Vascular Mild Cognitive Impairment: A Resting-State Functional MRI Study

Cited by 20 publications

References 36 publications

Distinctive Alterations of Functional Connectivity Strength between Vascular and Amnestic Mild Cognitive Impairment

Distinctive Alterations of Functional Connectivity Strength between Vascular and Amnestic Mild Cognitive Impairment

Functional connectivity dysfunction of insular subdivisions in cognitive impairment after acute mild traumatic brain injury

Different Modulatory Effects of Cognitive Training and Aerobic Exercise on Resting State Functional Connectivity of Entorhinal Cortex in Community-Dwelling Older Adults

Contact Info

Product

Resources

About