Aberrant Apolipoprotein E Expression and Cognitive Dysfunction in Patients with Poststroke Depression

Zhao-hui, Zhang; Mu, Junlin; Li, Jing; Li, Wenqiang; Song, Jinggui

doi:10.1089/gtmb.2012.0253

Cited by 17 publications

(15 citation statements)

References 21 publications

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“… 2 , 15 - 20 Two studies did not cite the mean age, only the age range of the participants, which was 15-85 years 21 for one study and 42-78 years for the other. 22 …”

Section: Resultsmentioning

confidence: 99%

“…The evaluation of P300 was used in 53.8% of the articles to identify the influence of age on cognitive processing performance. 5 , 15 - 17 , 19 , 21 , 23 - 29 In 19.2% of the studies, the P300 was used to compare the electrophysiological evaluation of healthy and cognitively impaired participants, 6 , 13 , 14 , 30 , 31 15.4% used electrophysiological evaluation to monitor the effects of therapies in clinical trials, 32 - 35 one study evaluated the P300 according to age, depression, and cognition, 2 one evaluated depression in post-stroke patients 22 and one paper studied the difference between older monolingual and bilingual adults. 18 A summary of the results is given in Table 1 .…”

Section: Resultsmentioning

confidence: 99%

“…The amplitude and latency values of P300 in healthy elderly are given in Table 2 , showing no pattern of response to the stimuli among the studies described. The amplitude values ranged from 2.2 µV (±0.2) 31 to 18.5 µV (±9.2) 34 and latency values from 320 ms (±20.2) 22 to 484 ms (±21), 31 independently of the channel (electrode) used to capture the response to the stimulus.…”

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

On the use of the P300 as a tool for cognitive processing assessment in healthy aging: A review

Pavarini

Brígola

Luchesi

et al. 2018

Dement. neuropsychol.

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Changes in patterns of performance for the cognitive functions of memory, processing speed, and focused attention are expected in old age.Objective:The main goal of this systematic review was to analyze the use of ERP in healthy elderly in studies evaluating the P300 components.Methods:A systematic review was carried out based on recommendations for nursing research on the databases LILACS, PsycINFO, PubMed, SCOPUS and Web of Science.Results:26 studies involving 940 healthy elderly were identified, most of which sought to identify and determine the influence of age on the P300.Conclusion:Although there is consensus in the literature that P300 latency is significantly longer in elderly with psychiatric disorders compared to healthy elderly, it was not possible to conclude P300 associations with gender, education and other cognitive tests.

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“… 2 , 15 - 20 Two studies did not cite the mean age, only the age range of the participants, which was 15-85 years 21 for one study and 42-78 years for the other. 22 …”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

On the use of the P300 as a tool for cognitive processing assessment in healthy aging: A review

Pavarini

Brígola

Luchesi

et al. 2018

Dement. neuropsychol.

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“…A total of 32 patients who received treatments within 3 d after suffering from cerebral infarction in the Department of Neurology of The Fifth Affiliated Hospital of Sun Yat-sen University from January 2017 to January 2018 were selected in the current study. The diagnosis of cerebral infarction was based on the cerebral infarction diagnosis standard (20) and confirmed using computed tomography. The 32 patients comprised 14 males and 18 females with age ranging from 48 to 78 yr. A cohort of 30 healthy volunteers served as the control group (age range, 52-83 yr); they had no history of hypertension, diabetes, hyperlipoidemia, or cardiovascular diseases.…”

Section: Study Subjectsmentioning

confidence: 99%

Long noncoding RNA CDKN2B‐AS1 interacts with transcription factor BCL11A to regulate progression of cerebral infarction through mediating MAP4K1 transcription

Lei

et al. 2019

FASEB j.

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The effective therapeutic approach of cerebral infarction is limited because of its underlying complexity. Recently, multiple long noncoding RNAs (lncRNAs) have been identified in the pathogenesis of cerebral infarction. Here, the current study aims to explore the interaction among lncRNA cyclin‐dependent kinase inhibitor‐2B–antisense RNA 1 (CDKN2B‐AS1), transcription factor B‐cell lymphoma/leukemia 11A (BCL11A), and MAPKK kinase kinase 1 (MAP4K1) and further investigate whether they affect cerebral infarction progression. The expression of CDKN2B‐AS1, BCL11A, and MAP4K1 was altered in lymphocytes extracted from patients with cerebral infarction. In order to identify their roles in regulatory T (Treg) cells, the proliferation and apoptosis of the CD4+CD25+ Treg cells were examined, and levels of IL‐4, IL‐10, and TGF‐β were determined. Also, the RNA crosstalk among CDKN2B‐AS1, BCL11A, and MAP4K1 was validated. Finally, we established a rat model of middle cerebral arterial occlusion to evaluate the neurologic impairment and cerebral infarction volume. The results revealed that lymphocytes in patients with cerebral infarction presented with the up‐regulated expression of CDKN2B‐AS1. Moreover, BCL11A could specifically bind to CDKN2B‐AS1 and MAP4K1 promoter so as to inhibit MAP4K1. Moreover, it was observed that down‐regulated CDKN2B‐AS1 inhibited CD4+CD25+ Treg‐cell proliferation, reduced levels of IL‐4, IL‐10, and TGF‐β and cerebral infarction volume, and elevated MAP4K1 expression. Collectively, our study provides evidence that CDKN2B‐AS1 silencing could increase MAP4K1 expression to inhibit the CD4+CD25+ Treg‐cell proliferation by reducing enrichment of transcription factor BCL11A, thereby protecting against cerebral infarction progression, highlighting a promising therapeutic strategy for treating cerebral infarction.—Lei, J.‐J., Li, H.‐Q., Mo, Z.‐H., Liu, K.‐J., Zhu, L.‐J., Li, C.‐Y., Chen, W.‐L., Zhang, L. Long noncoding RNA CDKN2B‐AS1 interacts with transcription factor BCL11A to regulate progression of cerebral infarction through mediating MAP4K1 transcription. FASEB J. 33, 7037–7048 (2019). http://www.fasebj.org

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“…Recently, chronic inflammation has been suggested as an important mechanism related to depression, and reduced anti-inflammatory cytokine function was associated with PSD [ 7 8 ]. Subtypes of intermediate-density lipoprotein and adipokines secreted from adipose tissue have been suggested as biomarkers related to depression [ 7 8 9 ].…”

Section: Introductionmentioning

confidence: 99%

The Association Between Serum Leptin Levels and Post-Stroke Depression: A Retrospective Clinical Study

et al. 2015

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ObjectiveTo investigate the question of whether serum leptin levels might be associated with post-stroke depression.MethodsWe studied 130 patients who experienced a first episode of stroke of more than three months' duration, without any previous history of depression or speech disorders. Data were collected regarding the patient demographics, depressive mood (Diagnostic and Statistical Manual of Mental Disorders 4th edition [DSM-IV] criteria and Beck Depression Inventory) and serum leptin levels measured by an enzyme-linked immunosorbent assay (ELISA). In addition, the Korean version of Modified Barthel Index (K-MBI) and Korean version of Mini-Mental State Examination (K-MMSE) were used to assess the subjects' independence, in regard to the activities of daily living and cognition. A statistical analysis was performed to determine differences the serum leptin levels between patients with depression and those without depression, and to determine the difference in the MBI and K-MMSE scores between the groups separated according to the serum leptin levels.ResultsHigher serum leptin levels were observed in patients with depression, compared with those without depression (38.5 ng/mL [range, 25.1-59.2 ng/mL] vs. 8.2 ng/mL [range, 4.9-17.8 ng/mL]; p<0.01. The serum leptin level showed an association with depression (odds ratio, 1.21; 95% confidence interval, 1.01-1.45; p=0.021). The K-MMSE and K-MBI improvement scores were lower, with statistical significance, in the group with the highest leptin level (>30 mg/dL), compared to the other two groups.ConclusionHigh serum leptin levels are associated with depression after stroke, and patients with elevated serum leptin levels were disadvantaged in regard to functional and cognitive outcomes.

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Aberrant Apolipoprotein E Expression and Cognitive Dysfunction in Patients with Poststroke Depression

Abstract: We suggest that aberrant serum ApoE together with abnormalities in some ERP components may be useful markers for assessment of PSD risk and clinical diagnosis.

Cited by 17 publications

References 21 publications

On the use of the P300 as a tool for cognitive processing assessment in healthy aging: A review

On the use of the P300 as a tool for cognitive processing assessment in healthy aging: A review

Long noncoding RNA CDKN2B‐AS1 interacts with transcription factor BCL11A to regulate progression of cerebral infarction through mediating MAP4K1 transcription

The Association Between Serum Leptin Levels and Post-Stroke Depression: A Retrospective Clinical Study

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