Aberrant allele-switch imprinting of a novel IGF1R intragenic antisense non-coding RNA in breast cancers

Kang, Lihua; Sun, Jian; Xue, Wei; Cui, Jiuwei; Wang, Guanjun; Hoffman, Andrew R.; Hu, Ji-Fan; Li, Wei

doi:10.1016/j.ejca.2014.10.031

Cited by 34 publications

(45 citation statements)

References 73 publications

(98 reference statements)

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“…(D) Bioinformatics predicts that TGFB1 had a "seed sequences" of miR-21, and miR-21 had no effect on luciferase activity of wild-type or mutant TGFB1 3′UTR in HK2 cells. [19]. The rs145204276 polymorphism of promoter region of GAS5 was related to susceptibility to HCC.…”

Section: Discussionmentioning

confidence: 98%

Rs145204276 polymorphism of GAS5 is associated with renal fibrosis via miR-21/SMAD/TGF-β1 signaling pathway

Liu¹,

Wang²,

Feng³

et al. 2018

Oncotarget

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Section: Discussionmentioning

confidence: 98%

Rs145204276 polymorphism of GAS5 is associated with renal fibrosis via miR-21/SMAD/TGF-β1 signaling pathway

Liu¹,

Wang²,

Feng³

et al. 2018

Oncotarget

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“…In the present study, by separating male and female blastocysts using an X egfp transgenic strain, we demonstrated that Plac1 gene is paternally expressed before implantation and then switched to be maternally expressed after implantation. Recently, transient imprinting and aberrant allele switching have been implicated in developmental and disease-related phenotypes [16,17]. For example, during mammalian development, many loci maintain parent-of-origin DNA methylation only briefly after fertilization [16].…”

Section: Discussionmentioning

confidence: 99%

Lentiviral Vector-Mediated Complementation Restored Fetal Viability but Not Placental Hyperplasia in Plac1-Deficient Mice1

Muto

Fujihara

Tobita

et al. 2016

Biology of Reproduction

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The X-linked Plac1 gene is maternally expressed in trophoblast cells during placentation, and its disruption causes placental hyperplasia and intrauterine growth restriction. In contrast, Plac1 is also reported to be one of the upregulated genes in the hyperplastic placenta generated by nuclear transfer. However, the effect of overexpressed Plac1 on placental formation and function remained unaddressed. We complemented the Plac1 knockout placental dysfunction by lentiviral vector-mediated, placenta-specific Plac1 transgene expression. Whereas fetal development and the morphology of maternal blood sinuses in the labyrinth zone improved, placental hyperplasia remained, with an expanded the junctional zone that migrated and encroached into the labyrinth zone. Further experiments revealed that wild-type placenta with transgenically expressed Plac1 resulted in placental hyperplasia without the encroaching of the junctional zone. Our findings suggest that Plac1 is involved in trophoblast cell proliferation, differentiation, and migration. Its proper expression is required for normal placentation and fetal development.

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“…IRAIN is an intragenic lncRNA within the insulin-like growth factor type I receptor locus with monoallelic expression from the paternal allele (43). IRAIN is aberrantly expressed in both tumors and peripheral blood leukocytes in breast cancer (BC) (43).…”

Section: Cancer-related Lncrnasmentioning

confidence: 99%

“…IRAIN is aberrantly expressed in both tumors and peripheral blood leukocytes in breast cancer (BC) (43). Analysis of lncRNAs in human BC clinical subtypes revealed that HOTAIR is significantly overexpressed in the human epidermal growth factor receptor 2-enriched subgroup, while HOTAIRM1 is overexpressed in the basal-like subgroup (44).…”

Section: Cancer-related Lncrnasmentioning

confidence: 99%

LncRNAs and cancer

Zhang

et al. 2016

Oncology Letters

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Abstract. Long non-coding RNAs (lncRNAs) are a group of non-coding RNAs composed of >200 nucleotides. Recent studies have revealed that lncRNAs exert an important role in the development and progression of cancer. In this review, the involvement of the most extensively investigated lncRNAs in cancers of the digestive, respiratory, reproductive, urinary and central nervous systems are discussed. LncRNAs function via molecular and biochemical mechanisms that include cis-and trans-regulation of gene expression, epigenetic modulation in the nucleus and post-transcriptional control in the cytoplasm. Although the detailed biological functions and molecular mechanisms of the majority of lncRNAs remain to be elucidated, this review aims to provide a novel insight into the diagnosis and treatment of cancer using lncRNAs.

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Aberrant allele-switch imprinting of a novel IGF1R intragenic antisense non-coding RNA in breast cancers

Cited by 34 publications

References 73 publications

Rs145204276 polymorphism of GAS5 is associated with renal fibrosis via miR-21/SMAD/TGF-β1 signaling pathway

Rs145204276 polymorphism of GAS5 is associated with renal fibrosis via miR-21/SMAD/TGF-β1 signaling pathway

Lentiviral Vector-Mediated Complementation Restored Fetal Viability but Not Placental Hyperplasia in Plac1-Deficient Mice1

LncRNAs and cancer

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