Aberrant allele frequencies of the SNPs located in microRNA target sites are potentially associated with human cancers

Yu, Zhenbao; Li, Zhen; Jolicoeur, Normand; Zhang, Linhua; Fortin, Yves; Wang, Edwin; Wu, Meiqun; Shen, Shi-Hsiang

doi:10.1093/nar/gkm480

Cited by 240 publications

(199 citation statements)

References 30 publications

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“…It also has been also reported that SNPs in miRNA-binding sites affect miRNA target expression and function and, thus, potentially are associated with cancer. 36 Although it remains to be determined whether the common variant of rs3842 in the 3 0 UTR of ABCB1 could affect gene regulation, the current case-control study indicates that this SNP may be associated with lung cancer through a possible miRNA-mediated mechanism.…”

Section: Discussionmentioning

confidence: 72%

Genetic susceptibility of lung cancer associated with common variants in the 3′ untranslated regions of the adenosine triphosphate‐binding cassette B1 (ABCB1) and ABCC1 candidate transporter genes for carcinogen export

Wang

Jin

Wang

et al. 2009

Cancer

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Although Parkinson's disease (PD) is traditionally considered a motor output disorder, recent evidence suggests that people with PD may have sensory and perceptual impairments that may underlie movement impairments. Yet there has not been any direct testing of perceptual judgments, especially when manipulating the sensory feedback on which these judgments are made. The present study investigated how perception might be influenced by sensory feedback to contribute to height estimations and obstacle stepping in PD relative to healthy age‐matched control participants. Perceptual judgment accuracy was evaluated by judging 3 typically encountered obstacle heights in 2 sensory feedback conditions: (1) vision of foot available and (2) without vision of foot (reliance on proprioceptive feedback to estimate height). Then participants proceeded to walk and step over the obstacle. Fifteen individuals with PD and 15 healthy control participants completed the task. As seen with toe elevation, toe elevation variability, and toe error measures, individuals with PD overestimated the obstacle height and were significantly more variable when relying solely on proprioception (in contrast to when vision was available) compared with healthy controls, although no differences between groups in obstacle crossing were found. These results support the notion that sensory deficits may contribute to inaccuracy of perceptual judgment and has the potential to contribute to gait behaviors such as tripping and falling, especially when vision is not available. Future studies should carefully consider the impact of sensory and perceptual deficits that might contribute to movement planning problems and consequentially movement impairments. © 2011 Movement Disorder Society

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Section: Discussionmentioning

confidence: 72%

Genetic susceptibility of lung cancer associated with common variants in the 3′ untranslated regions of the adenosine triphosphate‐binding cassette B1 (ABCB1) and ABCC1 candidate transporter genes for carcinogen export

Wang

Jin

Wang

et al. 2009

Cancer

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“…Recently, SNPs that could affect response to miRs were noted in miR target site sequences (159,160). Correlations between miR polymorphisms and SNPs in miR target sites with risk of bladder and colorectal cancers were reported (161)(162)(163). Hence, examination of SNPs in miR-binding sites may also provide key insights into various human diseases.…”

Section: Clinical Applications Therapeutic Strategies and Perspectivesmentioning

confidence: 99%

MicroRNAs and Their Role in Progressive Kidney Diseases

Kato

Arce

Natarajan

2009

Clinical Journal of the American Society of Nephrology

145

105

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MicroRNAs (miRs) are a family of short non-coding RNAs. These endogenously produced factors have been shown to play important roles in gene regulation. The discovery of miRs has greatly expanded our knowledge of gene regulation at the posttranscriptional level. miRs inhibit target gene expression by blocking protein translation or by inducing mRNA degradation and therefore have the potential to modulate physiologic and pathologic processes. The imperative need to determine their cellular targets and disease relevance has sparked an unprecedented explosion of research in the miR field. Recent findings have revealed critical functions for specific miRs in cellular events such as proliferation, differentiation, development, and immune responses and in the regulation of genes relevant to human diseases. Of particular interest to renal researchers are recent reports that key miRs are highly expressed in the kidney and can act as effectors of TGF-␤ actions and high glucose in diabetic kidney disease. Moreover, podocyte-specific deletion of Dicer, a key enzyme involved in miR biogenesis, led to proteinuria and severe renal dysfunction in mice. Hence, studies aimed at determining the in vitro and in vivo functions of miRs in the kidney could determine their value as therapeutic targets for progressive renal glomerular and tubular diseases. Translational approaches could be facilitated by the development of effective inhibitors of specific miRs and methods for optimal delivery of anti-miRs to the kidney. The major goal of this review is to highlight key functions of these miRs and their relationships to human diseases, with special emphasis on diabetic kidney disease.

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“…30 For example, two groups have evaluated the presence of SNPs located in miRNA-binding sites of the 3 0 UTR of several genes and SNPs in the micro-RNA seed regions by genome-wide analyses. 54,55 Yu et al 54 were able to identify twelve miRNA binding SNPs that display an aberrant allele frequency in human cancers. Moreover, Saunders et al 55 were able to identify approximately 250 SNPs that create novel target sites for miRNAs in humans and may result in phenotypic differences.…”

Section: Micrornas In Complex Diseasesmentioning

confidence: 99%