Abelson murine leukemia virus: Effect of helper virus from regressing friend virus on leukemia development

Hines, David L.; Gragowski, L

doi:10.1016/0145-2126(83)90015-2

Cited by 9 publications

(3 citation statements)

References 29 publications

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“…Rosenberg and Baltimore (28) and Scher (32) noted that whereas any replication competent helper virus allowed A-MuLV transformation of 3T3 cells, leukemogenic helper virus was required for in vivo transformation. Hines and Gragowski (12) recently showed that the tumor cell type and the course of peripheral (nonthymic) A-MuLV disease are unaltered by the use of the regressor Friend helper virus. Thus, the leukemogenic helper dependence of A-MuLV transformation of normal cells may be transient.…”

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confidence: 99%

Thymocyte subsets transformed by Abelson murine leukemia virus.

Cook¹

1985

Mol. Cell. Biol.

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The infectious complex of Abelson murine leukemia virus was altered by replacing its usual helper virus, Moloney leukemia virus, with radiation leukemia virus (RadLV). After intrathymic injection of the Abelson-RadLV complex, thymomas arose rapidly, as described previously for injection of the Abelson-Moloney complex. Cell lines were derived from thymomas induced by each Abelson virus complex and were classified according to normal thymus cell phenotypes. Each virus complex induced some cell lines which were like a 0.7% subpopulation of murine thymocytes in that they failed to express the Thy-i cell-surface antigen. These lines are thus far indistinguishable from some Abelson-derived bone marrow transformants classified as pre-B cells. However, the Abelson-Moloney complex induced some cell lines which expressed low levels of Thy-i and which shared most markers with immature blast cells of the thymic medulla, whereas the Abelson-RadLV complex induced some lines which were clearly like thymic cortex blast cells. Thus, Abelson virus can induce thymoma cell lines of at least two, and possibly three, distinct phenotypes corresponding to normal thymocyte blast subsets, the determination of which can be influenced by helper virus sequences.

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Section: Downloaded Frommentioning

confidence: 99%

Thymocyte subsets transformed by Abelson murine leukemia virus.

Cook¹

1985

Mol. Cell. Biol.

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“…is an acute transforming, replication-defective retrovirus that primarily induces non-thymic lymphomas of the pre-B cell phenotype (Abelson and Rabstein, 1970;Prekumar et al, 1975;Boss et al, 1979). A-MuLV has also been shown, however, to induce a variety of hemopoietic tumors including plasmacytomas (Potter et al, 19731, myelomonocytic leukemias (Rashke et al, 1978;Hines and Gragowski, 1983), T-cell lymphomas (Cook, 19821, and mastocytomas (Mendoza and Metzger, 1976;Risser et al, 1978). In addition, A-MuLV can transform both hemopoietic cells and fibroblasts in vitro (Ftosenberg et al, 1975;Scher and Siegler, 1975).…”

Section: Abelson Murine Leukemia Virus (A-mulv)mentioning

confidence: 99%

“…The origin and preliminary characterization of the cloned AC5, AC8, and C11 cell lines has been described (Hines, 1985). These cell lines were derived from a leukemic BALB/c mouse that had been infected with a A-MuLV stock prepared by infection of the ANN-1 cell line with the helper virus from the regressing strain of Friend virus (Hines and Gragowski, 1983). The cell lines were routinely passaged in RPMI 1640 medium (GIBCO, Grand Island, NY) supplemented with 10% heat-inactivated fetal calf serum (FCS, GIBCO, Grand Island, NY), 10% heat-inactivated calf serum (CS, Hyclone Labs, Logan, Utah), 50 pM 2-mercaptoethanol, and 5 Fg/ml gentamycin.…”

Section: Cells and Cell Linesmentioning

confidence: 99%

Proliferation and differentiation of abelson virus‐infected murine myeloid leukemia cell lines does not involve an autocrine mechanism

Hines

1988

Journal Cellular Physiology

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Culture in agar of cloned promonocytic leukemia cell lines derived from Abelson virus-infected mice produced colonies of both a compact and diffuse morphology. Diffuse colonies contained fewer cells capable of forming colonies when recultured in agar than did compact colonies. Serial subcloning of cells from diffuse, but not compact, colonies ultimately led to the complete loss of colony-forming cells, i.e., to clonal extinction. The production of both compact and diffuse agar colonies was independent of the cell density of either the static liquid culture from which cells were taken for culture in agar, or the number of cells per agar culture. Furthermore, bioassays of culture supernatants indicated the leukemia cells did not secrete hemopoietic growth factors active on normal hemopoietic cells, transforming growth factors active on adherent cell lines, or factors that influenced the growth of the leukemic cells themselves. Collectively, these data suggest neither growth-factor independent replication nor the spontaneous differentiation of Abelson virus-infected myeloid cells involves autocrine secretion of growth regulators.

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Differentiation of abelson murine leukemia virus‐infected promonocytic leukemia cells

Hines

1985

Intl Journal of Cancer

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Virus-producing, tumorigenic, promonocytic leukemia cell lines were derived from Abelson murine leukemia virus-infected mice. This study shows that, of these 25 cloned lines, 22 were capable of extensive differentiation. It also shows that granulocyte-macrophage colony-stimulating activity increased the proportion of differentiating cells in 17/22 lines. Cells from agar colonies with a diffuse colony morphology had an increased expression of mature macrophage phenotypic characteristics, and a reduced proliferative capacity in vitro, compared to cells from agar colonies with a compact colony morphology. Cells from diffuse colonies also produced less Abelson virus, and were less tumorigenic in vivo than cells from compact colonies. Together, these results suggest some Abelson virus-producing leukemic cells are not blocked in their capacity to differentiate and are capable of reversing the transformed phenotype.

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Abelson murine leukemia virus: Effect of helper virus from regressing friend virus on leukemia development

Cited by 9 publications

References 29 publications

Thymocyte subsets transformed by Abelson murine leukemia virus.

Thymocyte subsets transformed by Abelson murine leukemia virus.

Proliferation and differentiation of abelson virus‐infected murine myeloid leukemia cell lines does not involve an autocrine mechanism

Differentiation of abelson murine leukemia virus‐infected promonocytic leukemia cells

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