Abductor digiti minimi muscle flap in reconstruction of diabetic foot ulcers: A case series

Shirol, S. S.; Nimbaragi, Geeta; Prabhu, Mahesh; Ratkal, Jaideep

doi:10.1007/s00238-013-0923-3

Cited by 12 publications

(5 citation statements)

References 11 publications

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“…Healthcare-acquired infections, called nosocomial, are a major public health concern due to the associated morbidity and mortality [ 1 ]. The prevalence rate in industrialized countries varies from 3.5 to 12%, while rates of 18% have been reported in underdeveloped countries [ 2 ]. In Europe, this corresponds to more than 4 million affected people and approximately 40,000 deaths each year, making them the sixth leading cause of death [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Investigation of the Antibacterial Properties of Silver-Doped Amorphous Carbon Coatings Produced by Low Pressure Magnetron Assisted Acetylene Discharges

Job

Laloy

Maloteau

et al. 2022

IJMS

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Hospital-acquired infections are responsible for a significant part of morbidity and mortality. Among the possible modes of transmission, this study focuses on environmental surfaces by developing innovative antibacterial coatings that can be applied on interior fittings in hospitals. This work aims to optimize a coating made of an amorphous carbon matrix doped with silver (a-C:H:Ag) produced by a hybrid PVD/PECVD process and to evaluate its antibacterial activity. We present a coating characterization (chemical composition and morphology) as well as its stability in an ageing process and after multiple exposures to bacteria. The antibacterial activity of the coatings is demonstrated against Escherichia coli (Gram-negative) and Staphylococcus aureus (Gram-positive) bacteria through several bioassays. Moreover, the data suggest a crucial role of silver diffusion towards the surface and nanoparticle formation to explain the very promising anti-bacterial activities reported in this work.

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Section: Introductionmentioning

confidence: 99%

Investigation of the Antibacterial Properties of Silver-Doped Amorphous Carbon Coatings Produced by Low Pressure Magnetron Assisted Acetylene Discharges

Job

Laloy

Maloteau

et al. 2022

IJMS

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“…In high-income countries, approximately 30% of patients in intensive care units (ICU) are affected by at least one HCAI, from 3.5% to 12.0% of hospitalized patients have HCAIs (the EU average is 7.1%). In low-and middle-income countries HCAIs varies between 5.7% and 19.1% the frequency of ICU-acquired infection is at least 2─3 fold higher than in high-income countries and it can reach 88.9% of hospitalized patients (2). From all types of HCAIs, the device-associated infection are up to 13 times higher than in others types of HCAIs.…”

Section: Introductionmentioning

confidence: 95%

“…Health care-associated infections (HCAIs) is a global health problem, it is an infections that occur while receiving health care, developed in a hospital or other health care facility that first appear 48 hours or more after hospital admission, or within 30 days after having received health care, provided that at the time of hospitalization patients were not in the incubation period (1,2).…”

Section: Introductionmentioning

confidence: 99%

Epidemiological and Microbiological Aspects of Health Care-associated Infections in Ukraine During the 2009–2019 Period

Konechnyi¹,

Panas²,

Tymchuk³

et al. 2020

Preprint

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Statistical data on officially registered cases of health care-associated infections (HCAIs) in Ukraine in the period 2009-2019 have been analysed. On average, 5089±756 cases of HCAIs were registered annually. Odessa region of Ukraine is the leading country in the number of reported cases. The majority of HCAIs cases involve surgical and therapeutic invasive interventions and perinatal HCAIs. On average, 78.0±5.8 % of HCAIs cases involved adults. The estimated minimum number of HCAIs in Ukraine was expected to be about 1 million per year. Official statistics on registered cases of HCAIs in Ukraine do not reflect reality, so the system of registration and investigation of HCAIs in Ukraine needs to be reformed.

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“…Hospital-acquired infections (HAIs), also known as nosocomial infections, are a global health concern, affecting millions of patients each year. Many of these infections go on to become systemic, leading to significant morbidity, mortality, and financial burden to healthcare systems. , According to a World Health Organization report, at a given time, almost 7 patients in developed countries and 10 patients in developing countries out of every 100 hospitalized patients are suffering from nosocomial infections . In 2011, there were 721,800 nosocomial infections reported in the United States alone; many of these HAIs showed multidrug resistance, which makes treatment quite challenging. , It is predicted that approximately 10 million people will be affected from such multidrug-resistant infections by 2050 .…”

Section: Introductionmentioning

confidence: 99%

“…1,2 According to a World Health Organization report, at a given time, almost 7 patients in developed countries and 10 patients in developing countries out of every 100 hospitalized patients are suffering from nosocomial infections. 3 In 2011, there were 721,800 nosocomial infections reported in the United States alone; many of these HAIs showed multidrug resistance, which makes treatment quite challenging. 4,5 It is predicted that approximately 10 million people will be affected from such multidrugresistant infections by 2050.…”

Section: ■ Introductionmentioning

confidence: 99%

Polyglycerol-Based Macromolecular Iron Chelator Adjuvants for Antibiotics To Treat Drug-Resistant Bacteria

Abbina

Gill

Mathew

et al. 2020

ACS Appl. Mater. Interfaces

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Iron is an essential micronutrient for life. Its redox activity is a key component in a plethora of vital enzymatic reactions that take place in processes such as drug metabolism, DNA synthesis, steroid synthesis, gene regulation, and cellular respiration (oxygen transport and the electron transport chain). Bacteria are highly dependent on iron for their survival and growth and have specific mechanisms to acquire iron. Limiting the availability of iron to bacteria, thereby preventing their growth, provides new opportunities to treat infection in the era of the persistent rise of antibiotic-resistant bacteria. In this work, we have developed macromolecular iron chelators, conjugates of a high-affinity iron chelator (HBEDS) with polyglycerol, in an attempt to sequester iron uptake by bacteria to limit their growth in order to enhance antibiotic activity. The new macromolecular chelators are successful in slowing the growth of Staphylococcus aureus and worked as an efficient bacteriostatic against S. aureus. Further, these cytocompatible macrochelators acted as effective adjuvants to prevent bacterial growth when used in conjunction with antibiotics. The adjuvant activity of the macrochelators depends on their molecular weight and the chelator density on these molecules. These selective macro iron(III) chelators are highly efficient in growth inhibition and killing of methicillin-resistant S. aureus in conjunction with a low concentration of rifampicin.

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Abductor digiti minimi muscle flap in reconstruction of diabetic foot ulcers: A case series

Cited by 12 publications

References 11 publications

Investigation of the Antibacterial Properties of Silver-Doped Amorphous Carbon Coatings Produced by Low Pressure Magnetron Assisted Acetylene Discharges

Investigation of the Antibacterial Properties of Silver-Doped Amorphous Carbon Coatings Produced by Low Pressure Magnetron Assisted Acetylene Discharges

Epidemiological and Microbiological Aspects of Health Care-associated Infections in Ukraine During the 2009–2019 Period

Polyglycerol-Based Macromolecular Iron Chelator Adjuvants for Antibiotics To Treat Drug-Resistant Bacteria

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