Abdominal Wall Reconstruction for Desmoid Tumors Following Radical Resection from the Abdominoplasty Incision

Erdoğan, Osman; Parlakgümüş, Alper; Külahçı, Özgür; İrkörücü, Oktay

doi:10.4103/njcp.njcp_246_20

Cited by 3 publications

(6 citation statements)

References 9 publications

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“…Complications following nonsurgical treatment, such as infertility and cardiotoxicity caused by chemotherapy, should thus be taken into consideration before application. 3 , 4 Negative resection margin (R0 resection) is controversial and no longer a remarkable predictor of tumor recurrence in recent studies. 3 However, incomplete excision of the tumor may consequently be associated with recurrence; therefore, a 1- to 3-cm circumferential healthy tissue margin was recommended.…”

Section: Discussionmentioning

confidence: 99%

“… 3 , 4 Negative resection margin (R0 resection) is controversial and no longer a remarkable predictor of tumor recurrence in recent studies. 3 However, incomplete excision of the tumor may consequently be associated with recurrence; therefore, a 1- to 3-cm circumferential healthy tissue margin was recommended. 3 , 5 Wide local excision remains the primary treatment option for abdominal wall DTs because of its advantages of simple surgical technique and clear margins.…”

Section: Discussionmentioning

confidence: 99%

“… 3 However, incomplete excision of the tumor may consequently be associated with recurrence; therefore, a 1- to 3-cm circumferential healthy tissue margin was recommended. 3 , 5 Wide local excision remains the primary treatment option for abdominal wall DTs because of its advantages of simple surgical technique and clear margins. 6 Abdominoplasty access had ever been presented for a broad operative field and better cosmetic outcomes, 3 , 5 although skin excision may not be necessary for resection of abdominal wall DT.…”

Section: Discussionmentioning

confidence: 99%

“… 2 Surgical excision is still the first-line treatment for resectable tumors, whereas nonsurgical treatments, including systemic chemotherapy, hormone therapy, nonsteroidal anti-inflammatory drugs, and radiation, have shown roles as alternatives. 3 , 4 The approach for abdominal wall DT resection is commonly via direct incision or preexisting scars; however, abdominoplasty access has been applied for a better cosmetic outcome. 3 , 5 Herein, we report a case of abdominal wall DT in a patient who underwent radical tumor excision via a fleur-de-lis miniabdominoplasty access.…”

mentioning

confidence: 99%

“… 3 , 4 The approach for abdominal wall DT resection is commonly via direct incision or preexisting scars; however, abdominoplasty access has been applied for a better cosmetic outcome. 3 , 5 Herein, we report a case of abdominal wall DT in a patient who underwent radical tumor excision via a fleur-de-lis miniabdominoplasty access.…”

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confidence: 99%

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Fleur-de-lis Miniabdominoplasty Access in Radical Resection of a Large Abdominal Wall Desmoid Tumor

Chen,

Kao,

2023

Plastic and Reconstructive Surgery - Global Open

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Summary: Desmoid tumor (DT) is a rare benign soft tissue neoplasm that develops in the musculoaponeurotic structures, one-third of which involve the abdominal wall. Due to local aggressive infiltration of DT, the recurrence rate is approximately 45%–77%, according to the locations of the tumors, and 25%–50% for those with unclear surgical margins. Limited by adverse effects of radiotherapy and chemotherapy, surgical excision is still the standard management recommended. Differing from traditional midline or abdominoplasty access, we applied a fleur-de-lis miniabdominoplasty access in a 37-year-old woman who had primary abdominal wall DT with less than 1 cm depth from the umbilicus. The approach not only provides a better surgical field for radical tumor excision but also eliminates redundant skin and dog-ear formation at bilateral flanks. An appropriate surgical margin could be processed simultaneously when the tumor was close to the skin surface. After abdominal wall reconstruction, the postoperative course was uneventful, and no DT recurrence or incisional hernia was noted during the follow-up. The patient was satisfied with the tumor treatment and aesthetic outcome.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Fleur-de-lis Miniabdominoplasty Access in Radical Resection of a Large Abdominal Wall Desmoid Tumor

Chen,

Kao,

2023

Plastic and Reconstructive Surgery - Global Open

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Desmoid tumors of rectus abdominis: A case report and literature review

Guo,

Zhang,

et al. 2024

Medicine

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Rationale: Desmoid tumor (DT) is a rare soft tissue tumor that can occur anywhere in the body. Abdominal wall DT presents unique clinical challenges due to its distinctive manifestations, treatment modalities, and the lack of biomarkers for diagnosis and recurrence prediction, making clinical decisions exceedingly complex. Patient concerns: A 32-year-old female who underwent radical resection combined with patch reinforcement for rectus abdominis DT, successfully alleviating abdominal discomfort, with no recurrence during the 6-month follow-up after surgery. Diagnoses: Based on the imaging studies and medical history, the patient underwent radical surgical resection. Histopathology reveals that the tumor cells predominantly composed of proliferative fibroblasts with local collagen deposition. The lesional cells show positive staining for β-catenin, indicating a diagnosis of DT. Interventions: The patient underwent radical surgical resection with patch reinforcement to repair the abdominal wall defect. Pathology confirmed negative margins, achieving an R0 resection, and genetic testing identified a T41A mutation in CTNNB1. Consequently, no additional adjuvant therapy was administered postoperatively. Outcomes: The patient was discharged with the incision healing well after 3 days postoperation. Upon reexamination 6 months later, no recurrence or adverse complications were observed. Lessons: Abdominal wall DT treatment requires personalized plans from multidisciplinary team discussions. Genetic testing plays a crucial role in identifying novel biomarkers for abdominal wall DT. We have once again demonstrated the significant clinical significance of CTNNB1 mutations in the diagnosis and progression of abdominal wall DT. Additionally, genes such as CCND1, CYP3A4, SLIT1, RRM1, STIM1, ESR2, UGT1A1, among others, may also be closely associated with the progression of abdominal wall DT. Future research should delve deeper into and systematically evaluate the precise impact of these genetic mutations on treatment selection and prognosis for abdominal wall DT, in order to better guide patient management and treatment decisions.

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Role of the Interventional Radiologist in the Treatment of Desmoid Tumors

Goldberg

Woodhead

Hannallah

et al. 2023

Life

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Desmoid tumors are locally aggressive soft tissue tumors with variable clinical presentation. As is the case with most relatively rare tumors, a multidisciplinary team approach is required to best manage these patients. Surgical resection, systemic therapy, and radiation therapy have classically been mainstays of treatment for desmoid tumors; however, a more conservative “wait-and-see” approach has been adopted given their high recurrence rates and significant morbidity associated with the aforementioned therapies. Given the challenges of classical treatment methods, interventional radiologists have begun to play a significant role in minimally invasive interventions for desmoid tumors. Herein, the authors review imaging characteristics of desmoid tumors, current management recommendations, and minimally invasive therapeutic intervention options.

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Abdominal Wall Reconstruction for Desmoid Tumors Following Radical Resection from the Abdominoplasty Incision

Cited by 3 publications

References 9 publications

Fleur-de-lis Miniabdominoplasty Access in Radical Resection of a Large Abdominal Wall Desmoid Tumor

Fleur-de-lis Miniabdominoplasty Access in Radical Resection of a Large Abdominal Wall Desmoid Tumor

Desmoid tumors of rectus abdominis: A case report and literature review

Role of the Interventional Radiologist in the Treatment of Desmoid Tumors

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