Abdominal subcutaneous fat gene expression and circulating levels of leptin and adiponectin in polycystic ovary syndrome

Lecke, Sheila Bünecker; Mattei, Fabrício Nicolao; Morsch, Débora Martinho; Spritzer, Poli Mara

doi:10.1016/j.fertnstert.2011.02.041

Cited by 62 publications

(51 citation statements)

References 56 publications

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“…As previously reported by us, leptin gene expression was higher in SC fat of overweight/ obese PCOS in comparison with normal-weight controls. In contrast, adiponectin gene expression did not differ between obese and non-obese subgroups (Lecke et al 2011a(Lecke et al , 2013b. These data are in agreement with other reports regarding PCOS and control populations (Wang et al 2012).…”

Section: Leptin and Adiponectinsupporting

confidence: 92%

“…While our group and other authors found similar circulating adiponectin levels in BMI-matched PCOS and control women (Lecke et al 2011a, 2013b, Pepene 2012, Tan et al 2013, other studies have reported lower adiponectin levels in PCOS women in comparison with healthy controls, independently of BMI: a meta-analysis including more than 3500 subjects (PCOS women and healthy BMI-matched controls) of various ages with different levels of total testosterone and insulin found that adiponectin was significantly lower in PCOS (Li et al 2014). Reduced adiponectin levels appear to play a role in promoting insulin resistance increasing triglycerides and small and dense LDL particles (Tan et al 2006a).…”

Section: Leptin and Adiponectinsupporting

confidence: 76%

“…We have previously reported that leptin serum levels are higher in overweight/obese PCOS women and also in BMI-matched controls than in normal-weight PCOS and controls (Spritzer et al 2005, Lecke et al 2011a, 2013b. In fact, most published studies about circulating leptin levels in PCOS and controls, including adolescents and pre-and postmenopausal women, stratified or not by BMI, have demonstrated that circulating leptin levels are associated with the amount of body fat, being significantly increased in overweight/obese subgroups, independently of the presence of PCOS (Plati et al 2010, Tan et al 2013.…”

Section: Leptin and Adiponectinmentioning

confidence: 91%

“…In fact, there is evidence that androgens may inhibit preadipocyte differentiation in nonobese healthy women (Chazenbalk et al 2013). Adipose tissue is a dynamic organ, secreting hormones, adipokines, and cytokines, and contributing to endocrine processes that regulate glucose and fatty metabolism, immunity, inflammatory response, and reproduction, among other functions (Lecke et al 2011a(Lecke et al , 2013a.…”

Section: Introductionmentioning

confidence: 99%

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Adipose tissue dysfunction, adipokines, and low-grade chronic inflammation in polycystic ovary syndrome

Spritzer¹,

Lecke²,

Satler³

et al. 2015

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Polycystic ovary syndrome (PCOS), a complex condition that affects women of reproductive age, is characterized by ovulatory dysfunction and androgen excess. Women with PCOS present higher prevalence of obesity, central adiposity, and dyslipidemia, and face increased risk of type 2 diabetes. PCOS is closely linked to functional derangements in adipose tissue. Adipocytes seem to be prone to hypertrophy when exposed to androgen excess, as experienced by women with PCOS, and both adipose tissue hypertrophy and hyperandrogenism are related to insulin resistance. Hypertrophic adipocytes are more susceptible to inflammation, apoptosis, fibrosis, and release of free fatty acids. Disturbed secretion of adipokines may also impact the pathophysiology of PCOS through their influence on metabolism and on sex steroid secretion. Chronic low-grade inflammation in PCOS is also related to hyperandrogenism and to the hypertrophy of adipocytes, causing compression phenomena in the stromal vessels, leading to adipose tissue hypoperfusion and altered secretion of cytokines. Lifestyle changes are the first-line intervention for reducing metabolic risks in PCOS and the addition of an insulin-sensitizing drug might be required. Nevertheless, there is not sufficient evidence in favor of any specific pharmacologic therapies to directly oppose inflammation. Further studies are warranted to identify an adipokine that could serve as an indirect marker of adipocyte production in PCOS, representing a reliable sign of metabolic alteration in this syndrome.

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Section: Leptin and Adiponectinsupporting

confidence: 92%

Section: Leptin and Adiponectinsupporting

confidence: 76%

Section: Leptin and Adiponectinmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Adipose tissue dysfunction, adipokines, and low-grade chronic inflammation in polycystic ovary syndrome

Spritzer¹,

Lecke²,

Satler³

et al. 2015

Reproduction

Self Cite

242

193

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“…Adipose tissue total RNA was reverse-transcribed into complementary DNA samples, which were used as template for quantitative real-time PCR amplification as previously described (Carmina et al, 2008;Lecke et al, 2011a;Svendsen et al, 2012).…”

Section: Methodsmentioning

confidence: 99%

Association between adipose tissue expression and serum levels of leptin and adiponectin in women with polycystic ovary syndrome

Lecke¹,

Morsch²,

Spritzer³

2013

Genet. Mol. Res.

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ABSTRACT. We reviewed emerging evidence linking serum levels and adipose tissue expression of leptin and adiponectin in women with polycystic ovary syndrome (PCOS). Previous data obtained by our group from a sample of overweight/obese PCOS women and a control sample of normal weight controls, both stratified by BMI, were reanalyzed. Circulating levels of leptin and adiponectin were determined by commercially available enzyme-linked immunosorbent assays. Adipose tissue total RNA was reserve-transcripted into complementary DNA samples, which were used as templates for quantitative real-time PCR amplification. Positive correlations were found between serum and mRNA levels for both leptin (r = 0.321; P = 0.005) and adiponectin (r = 0.266; P = 0.024). Deter-©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 12 (4): 4292-4296 (2013) Adipose tissue expression in PCOS 4293 mination of leptin and adiponectin serum levels could serve as an indirect method to assess adipocyte production, since leptin and adiponectin are predominantly produced by subcutaneous adipocytes in women.

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Focus on metabolic and nutritional correlates of polycystic ovary syndrome and update on nutritional management of these critical phenomena

Rondanelli

Perna

Faliva

et al. 2014

Arch Gynecol Obstet

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Abdominal subcutaneous fat gene expression and circulating levels of leptin and adiponectin in polycystic ovary syndrome

Cited by 62 publications

References 56 publications

Adipose tissue dysfunction, adipokines, and low-grade chronic inflammation in polycystic ovary syndrome

Adipose tissue dysfunction, adipokines, and low-grade chronic inflammation in polycystic ovary syndrome

Association between adipose tissue expression and serum levels of leptin and adiponectin in women with polycystic ovary syndrome

Focus on metabolic and nutritional correlates of polycystic ovary syndrome and update on nutritional management of these critical phenomena

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