Abdominal Pain in Children Develops With Age and Increases With Psychosocial Factors

Jones, Michael; Faresjö, Åshild Olsen; Beath, Alissa; Faresjö, Tomas; Ludvigsson, Johnny

doi:10.1016/j.cgh.2019.04.036

Cited by 14 publications

(15 citation statements)

References 28 publications

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“…Abdominal pain is associated with depression, anxiety, reduced quality of life (Ayonrinde et al, 2020;Saps et al, 2009) and school absenteeism (Saps et al, 2009). The pathogenesis of FAPDs is complex; biological, psychological and psychosocial factors contribute to the development and maintenance of the disorder, (Jones et al, 2020;Rajindrajith et al, 2018;Van Oudenhove et al, 2016) and the prevalence of FAPDs is higher among girls than among boys (Ayonrinde et al, 2020;Korterink et al, 2015). Suffering from FAPDs is a great burden on these children and their families and often leads to frequent visits to health care services (Hoekman et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Dance and yoga reduced functional abdominal pain in young girls: A randomized controlled trial

Högström

Philipson

Ekstav

et al. 2021

European Journal of Pain

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Section: Introductionmentioning

confidence: 99%

Dance and yoga reduced functional abdominal pain in young girls: A randomized controlled trial

Högström

Philipson

Ekstav

et al. 2021

European Journal of Pain

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“…Também se notou que fatores associados ao desenvolvimento do sistema imunológico, mais especificamente na infância, como modalidade de parto, duração da amamentação, número de animais de estimação e educação materna e paterna influenciam na construção do sistema imunológico e podem contribuir para o surgimento de algum Distúrbio Gastrointestinal Funcional, como a Dispepsia Funcional (Koloski et al, 2015;Jones, Faresjö, Beath, Faresjö & Ludvigsson, 2020).…”

Section: Discussionunclassified

Repercussões imunes em pacientes com dispepsia funcional: Uma revisão sistemática

Nobre

Cândido

Medeiros

et al. 2021

RSD

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Introdução: A Dispepsia Funcional (DF) é um distúrbio crônico ou intermitente do estômago pela perda do equilíbrio homeostático, fazendo parte das Doenças Gastrointestinais Funcionais (FGIDs). Vários fatores podem estar envolvidos com a doença e suas repercussões imunes. Objetivo: Avaliar, em pacientes com Dispepsia Funcional, qual o risco de repercussões imunes. Método: Revisão Sistemática da Literatura. A busca de dados ocorreu em duas bases: Biblioteca Virtual em Saúde (BVS) e PubMed. A pergunta norteadora segue o acrônimo PO, sendo P os pacientes com DF e O as repercussões imunes. Utilizou-se a combinação dos descritores: “Dyspepsia” AND “Immune System”. Os critérios de inclusão utilizados foram qualquer ano de publicação, em português e inglês, artigos completos online e estudos de Coorte e Transversais que abordem a questão PO. Após a identificação inicial dos artigos, foi realizada leitura aos pares e seleção conforme critérios de elegibilidade. Resultados: Foram selecionados cinco artigos, com estudos do tipo Coorte e Transversais. Em pacientes com DF, há maior probabilidade de desenvolver determinadas doenças pela desregulação imunológica causada, como atopias, infecções e transtornos de humor. Um dos principais fatores causais é a inflamação acarretada por infecções, em que o estresse leva ao aumento das citocinas inflamatórias pelo organismo, que pode levar a quadros alérgicos e disfunções neurológicas. Conclusão: Evidenciou-se uma correlação entre a DF e o surgimento de atopias e transtornos de humor posteriores. Contudo, faz-se necessário investir em mais artigos para elucidar melhor a sobreposição entre tais doenças.

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“…Early childhood is a critical developmental period, and ELS may increase the predisposition to GI diseases, including IBS, in later life ( Wong et al, 2019 ; Jones et al, 2020 ; Ju et al, 2020 ; Low et al, 2020 ). Bradford et al (2012) investigated different early adverse life events and their association with IBS, and demonstrated that IBS patients had higher incidences of general trauma, physical punishment, and emotional abuse compared with controls.…”

Section: Evidence For Early Life Stress-induced Irritable Bowel Syndromementioning

confidence: 99%

“…Early life stress (ELS) and its role in the pathogenesis of IBS have gradually attracted increasing attention ( Ju et al, 2020 ). ELS is a risk factor for IBS development ( Jones et al, 2020 ; Ju et al, 2020 ; Low et al, 2020 ), and is more common in IBS patients than in healthy controls ( Bradford et al, 2012 ). Furthermore, ELS is correlated with the severity of IBS symptoms ( Park et al, 2016 ).…”

Section: Introductionmentioning

confidence: 99%

Potential Roles of Enterochromaffin Cells in Early Life Stress-Induced Irritable Bowel Syndrome

Tao

Zhu

et al. 2022

Front. Cell. Neurosci.

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Irritable bowel syndrome (IBS) is one of the most common functional gastrointestinal disorders, also known as disorders of the gut–brain interaction; however, the pathophysiology of IBS remains unclear. Early life stress (ELS) is one of the most common risk factors for IBS development. However, the molecular mechanisms by which ELS induces IBS remain unclear. Enterochromaffin cells (ECs), as a prime source of peripheral serotonin (5-HT), play a pivotal role in intestinal motility, secretion, proinflammatory and anti-inflammatory effects, and visceral sensation. ECs can sense various stimuli and microbiota metabolites such as short-chain fatty acids (SCFAs) and secondary bile acids. ECs can sense the luminal environment and transmit signals to the brain via exogenous vagal and spinal nerve afferents. Increasing evidence suggests that an ECs-5-HT signaling imbalance plays a crucial role in the pathogenesis of ELS-induced IBS. A recent study using a maternal separation (MS) animal model mimicking ELS showed that MS induced expansion of intestinal stem cells and their differentiation toward secretory lineages, including ECs, leading to ECs hyperplasia, increased 5-HT production, and visceral hyperalgesia. This suggests that ELS-induced IBS may be associated with increased ECs-5-HT signaling. Furthermore, ECs are closely related to corticotropin-releasing hormone, mast cells, neuron growth factor, bile acids, and SCFAs, all of which contribute to the pathogenesis of IBS. Collectively, ECs may play a role in the pathogenesis of ELS-induced IBS. Therefore, this review summarizes the physiological function of ECs and focuses on their potential role in the pathogenesis of IBS based on clinical and pre-clinical evidence.

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Abdominal Pain in Children Develops With Age and Increases With Psychosocial Factors

Cited by 14 publications

References 28 publications

Dance and yoga reduced functional abdominal pain in young girls: A randomized controlled trial

Dance and yoga reduced functional abdominal pain in young girls: A randomized controlled trial

Repercussões imunes em pacientes com dispepsia funcional: Uma revisão sistemática

Potential Roles of Enterochromaffin Cells in Early Life Stress-Induced Irritable Bowel Syndrome

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