Abdominal Pain: Essential Diagnosis and Management in Acute Medicine

SEZGIN, Seckin Bahar; Karcıoğlu, Özgür; YENİOCAK, Selman; HOSSEINZADEH, Mandana

doi:10.2174/97898150517801220101

Cited by 3 publications

(3 citation statements)

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“…ABP can manifest in a variety of ways. It can cause pain that is sometimes localized or on the left side, lasts for many days, and peaks in intensity in about 20-minutes 14 . Common symptoms include back discomfort that radiates and frequently has band-like qualities.…”

Section: Discussionmentioning

confidence: 99%

Frequency of Gall Stones in Patients with Acute Pancreatitis at Tertiary Care Hospital of Karachi, Pakistan

Iqbal,

Majeed,

Islam

et al. 2024

AMRJ

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Background: In developed countries, the adult population has a 20% incidence of gallstones, with a rise of 0.60 to 1.39% yearly. Our study aimed to determinethe frequency of gallstones in Acute Pancreatitis (AP) patients. Methods: A cross-sectional study was conducted atAbbasi Shaheed Hospital, Karachi, recruited all patients fulfilling inclusion criteria presented in the general surgery department from 3rd Oct 2020 to 3rd Oct 2021. After ethical approval and consent, a brief history was taken, and clinical examination, laboratory investigations, and ultrasound of the upper abdomenwere done to ascertain the frequency of gallstones. Results:A total of 93 patients diagnosed with APwere included in this study. Of these, 70 (50.6%) were male patients, and 23 (49.4%) were females,with a mean age of 40.752+11.764 years. The gallstones were found in 42 (45.2%) patients. Conclusion: The frequency of gallbladder stones was high in patients with AP. A prompt or a late diagnosis can directly affect a patient’s mortality and morbidity. Keywords: Abdomen, Acute Pancreatitis, Gallstones, Prevalence.

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Section: Discussionmentioning

confidence: 99%

Frequency of Gall Stones in Patients with Acute Pancreatitis at Tertiary Care Hospital of Karachi, Pakistan

Iqbal,

Majeed,

Islam

et al. 2024

AMRJ

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“…The stomach, duodenum, and esophagus are among the body areas where these ulcers can develop [35]. Intense pain and discomfort are frequently the hallmarks of acute ulcers, which can also present with symptoms including bleeding, nausea, vomiting, and bloating in the abdomen [36]. Chronic use of non-steroidal antiinflammatory medications (NSAIDs), an infestation of Helicobacter pylori, and excessive alcohol consumption, smoking, and stress are common causes of acute ulcers [37].…”

Section: • Duodenal Ulcersmentioning

confidence: 99%

Alleviating Ulcer Burdens Examining the Potential of Albizia Odoratissima Bark Extract as a Therapeutic Agent in Mice

Sultana,

Basha,

Teja

et al. 2024

UPJOZ

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Ulcerative stomach disease continues to be a prevalent gastrointestinal illness associated with high worldwide morbidity and medical costs. While nonsteroidal anti-inflammatory drugs (NSAIDs) and Helicobacter pylori infection are well-known risk factors for the development of peptic ulcers, recent evidence suggests a complex interaction between host factors and the gut microbiota in ulcer etiology. This study provides a comprehensive review of recent research investigating the relationship between the genesis and progression of peptic ulcers and dysbiosis of the gut microbiota. The study highlights several natural compounds, such as flavonoids, polyphenols, alkaloids, and polysaccharides, that have demonstrated anti-ulcer activity in experimental models and clinical trials. Mechanistic understanding clarifies the many pathways, including antibacterial, anti-inflammatory, and antioxidant ones, through which these drugs perform their medicinal effects. It is interesting to note that many natural compounds focus on many pathogenic procedures that aid in the development and spread of ulcers, resulting in multifactorial effects. Albizia odoratissima is a member of the Fabaceae family and has been used traditionally in many folk medicines due to its medicinal characteristics. This study used experimental models of stomach ulceration to investigate potential anti-ulcer properties of methanolic bark extract from Albizia odoratissima (MAO). The anti-ulcer qualities of MAO were evaluated in rats using models of stomach ulceration brought on by HCL. Many parameters were assessed when different doses of MAO were administered orally, including the ulcer index, mucosal injury to the stomach, mucin content, and antioxidant enzyme levels. Additionally, a histological analysis was carried out to evaluate the possible protective qualities of MAO against harm to the stomach mucosa.

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“…Escherichia coli, the most prevalent Gram-negative opportunistic pathogen in humans, is responsible for causing stomach ulcers and symptoms such as nausea, vomiting, and diarrhea. The severity of these symptoms can range from mild and watery to severe and bloody 4,8,9 . One of the most common cutaneous resident bacteria, Staphylococcus aureus is also antibiotic-resistant [9][10][11] .…”

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confidence: 99%

The dual activity of CaONPs as a cancer treatment substance and at the same time resistance to harmful microbes

Awaad,

Olama,

El-Subruiti

et al. 2023

Sci Rep

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Nanotechnology holds significant promise for the development of novel and necessary products that enhance human health. Pharmacology and nanotechnology have contributed to developing advanced and highly effective drugs for cancer treatment and combating microbial infections. The microbiological effectiveness against the variety of examined microorganisms was assessed using the time killer curve, scanning electron microscopy (SEM), MIC techniques, and the agar well diffusion method. SEM was utilized to enhance the analysis of the mechanisms underlying the bio-interface interaction and intracellular localization of calcium oxide nanoparticles (CaONPs). The MTT test was used to examine the cytotoxicity of CaONP anticancer activity in various cancer cells, including colon, breast, and hepatic cells. The efficacy of CaONPs as an anticancer medication was elucidated by analyzing the gene expression of both treated and untreated cancer cells. MIC and MBC of CaONPs against Escherichia coli and Staphylococcus epidermidis were 150, 150, 150, and 200 µg/ml, respectively. The MIC and MFC of CaONPs against Candida albicans were 200 µg/ml and 250 µg/ml, respectively. The IC50 values of various CaONPs vary depending on the type of cancer cells. The gene expression analysis of breast cancer cells undergoing treatment revealed the identification of several cancer-controlling genes, namely BAX, BCL2, P53, TERT, KRAS1, KRAS2, and RB1. The study demonstrated the notable antibacterial efficacy of CaONPs, highlighting their potential as cancer therapies.

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Abdominal Pain: Essential Diagnosis and Management in Acute Medicine

Cited by 3 publications

References 0 publications

Frequency of Gall Stones in Patients with Acute Pancreatitis at Tertiary Care Hospital of Karachi, Pakistan

Frequency of Gall Stones in Patients with Acute Pancreatitis at Tertiary Care Hospital of Karachi, Pakistan

Alleviating Ulcer Burdens Examining the Potential of Albizia Odoratissima Bark Extract as a Therapeutic Agent in Mice

The dual activity of CaONPs as a cancer treatment substance and at the same time resistance to harmful microbes

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