Abdominal obesity and the risk of colorectal adenoma

Hong, Shaodong; Cai, Quan-Cai; Chen, Dafan; Zhu, Wei; Huang, Wen; Li, Zhao‐Shen

doi:10.1097/cej.0b013e328351c775

Cited by 61 publications

(32 citation statements)

References 40 publications

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“…Other studies reported that cigarette smoking was associated with abdominal and visceral obesity [31,32]. However, our observation didn’t support such finding, and there was a little trend towards a higher prevalence in abdominal obesity with smoking, but not statistical significant.…”

Section: Discussioncontrasting

confidence: 99%

Prevalence of Obesity and Related Factors among Bouyei and Han Peoples in Guizhou Province, Southwest China

Wang

Pan

et al. 2015

PLoS ONE

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ObjectiveTo investigate the prevalence of general and abdominal obesity and associated factors in Bouyei and Han peoples.DesignA cross-sectional study was carried out in Guizhou province, southwest China in 2012, with multi-stage sampling to enroll 4551 participants aged 20 to 80 years. General and abdominal obesity were defined by World Health Organization (WHO) for Chinese. A design-based analysis was performed to evaluate prevalence of obesity and its related factors.ResultsBouyei people had a significantly lower prevalence of general obesity (4.8% vs. 10.9%, p < 0.05) and abdominal obesity (13.6% vs. 26.8%, p < 0.05) than that in Han people. Prevalence of obesity increased with age until middle-age period and declined thereafter. Men aged 40–49 years group and women aged 50–59 years group have the highest prevalence of general obesity. Prevalence of abdominal obesity was higher than that of general obesity. Middle-age, Higher income, Han people were significantly associated with an increased risk of General/abdominal obesity.ConclusionsBouyei people had a lower prevalence of general and abdominal obesity than the Han people. Etiological studies should be conducted to determine underlying genetic factors and dietary factors.

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Section: Discussioncontrasting

confidence: 99%

Prevalence of Obesity and Related Factors among Bouyei and Han Peoples in Guizhou Province, Southwest China

Wang

Pan

et al. 2015

PLoS ONE

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“…33–36 Although the results were expressed differently (BMI per 5-unit increase,33 BMI cut-off value35 36 or 10 cm increase in waist circumference34), all showed a small but significant association, with similar trends across races, country of origin, measured or self-reported BMI, and site other than rectal adenoma. The significance of the association persisted after adjustment for physical activity, family history of CRC, energy or alcohol intake, smoking habits or non-steroidal anti-inflammatory drug use (table 2).…”

Section: Resultsmentioning

confidence: 99%

Obesity and colorectal cancer

Bardou

Barkun

Martel

2013

Gut

640

479

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Excess body weight, as defined by the body mass index (BMI), has been associated with several diseases and includes subjects who are overweight (BMI ≥ 25-29.9 kg/m(2)) or obese (BMI ≥ 30 kg/m(2)). Overweight and obesity constitute the fifth leading risk for overall mortality, accounting for at least 2.8 million adult deaths each year. In addition around 11% of colorectal cancer (CRC) cases have been attributed to overweight and obesity in Europe. Epidemiological data suggest that obesity is associated with a 30-70% increased risk of colon cancer in men, whereas the association is less consistent in women. Similar trends exist for colorectal adenoma, although the risk appears lower. Visceral fat, or abdominal obesity, seems to be of greater concern than subcutaneous fat obesity, and any 1 kg/m(2) increase in BMI confers additional risk (HR 1.03). Obesity might be associated with worse cancer outcomes, such as recurrence of the primary cancer or mortality. Several factors, including reduced sensitivity to antiangiogenic-therapeutic regimens, might explain these differences. Except for wound infection, obesity has no significant impact on surgical procedures. The underlying mechanisms linking obesity to CRC are still a matter of debate, but metabolic syndrome, insulin resistance and modifications in levels of adipocytokines seem to be of great importance. Other biological factors such as the gut microbiota or bile acids are emerging. Many questions still remain unanswered: should preventive strategies specifically target obese patients? Is the risk of cancer great enough to propose prophylactic bariatric surgery in certain patients with obesity?

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“…A similar trend is observed with reference to colorectal adenomas. BMI was found to be an independent risk factor for advanced colorectal adenomas [17,18]. A significant correlation was found between BMI and CRC location.…”

Section: Discussionmentioning

confidence: 75%

Results of screening in Lublin Province, Poland, for colorectal cancer and neoplastic polyps - the role of environmental factors

Cichoż‐Lach

Szumiło

Celiński

et al. 2017

Ann Agric Environ Med.

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Introduction and objective. Screening colonoscopy is a recommended tool, and the most sensitive and cost-effective method for reducing the incidence of colorectal cancer (CRC). Objective. The purpose of the study was to present the results of a 5-year screening for early detection of CRC carried out among the population of the central-eastern regions of Poland, primarily in Lublin Province. Materials and method. Screening colonoscopy was conducted in a group of 1,009 patients -636 women and 373 men, aged 40-65 years. Results. Neoplastic polyps were found in 275 patients, advanced adenomas in 49 patients and adenocarcinoma in 13. 70.55% of neoplastic polyps was located in the distal colon, 18.9% in the proximal part and 10.55% in both regions, advanced adenomas in 79.59%, 8.16% and 12.25%, respectively. Adenocarcinoma was located in the proximal colon in 2 cases and in the distal region in 11 cases. Neoplastic polyps and advanced adenomas occurred significantly more frequently in smokers than in non-smokers. Neoplastic polyps were found statistically more frequent in males than in females, among the overweight and obese patients, than in subjects with normal BMI, and more frequently in the group of urban, compared to rural patients. However, the frequency of advanced adenomas and CRC was not statistically different in those groups. The incidence of CRC was statistically more frequent in males than in females. Smoking and male gender were significant risk factors for developing neoplastic polyps. Male gender seemed to predispose to CRC. Obesity was found to favour advanced adenomas. Conclusions. The results of screening found neoplastic polyps in every third person (mean) who did not have any symptoms suggestive of colon pathology. Advanced adenomas were found in 5% of the examined and CRC was detected in 1.29% of participants. Smoking, male gender and overweight were significant risk factors for developing neoplastic polyps. No correlation was found between gender and the location of neoplastic polyps and advanced adenomas in the colon.

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Abdominal obesity and the risk of colorectal adenoma

Cited by 61 publications

References 40 publications

Prevalence of Obesity and Related Factors among Bouyei and Han Peoples in Guizhou Province, Southwest China

Prevalence of Obesity and Related Factors among Bouyei and Han Peoples in Guizhou Province, Southwest China

Obesity and colorectal cancer

Results of screening in Lublin Province, Poland, for colorectal cancer and neoplastic polyps - the role of environmental factors

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