Abdominal obesity and gestational diabetes: the interactive role of magnesium

Mostafavi, Ehsan; Nargesi, Arash Aghajani; Asbagh, Firoozeh Akbari; Ghazizadeh, Zaniar; Heidari, Behnam; Mirmiranpoor, Hossein; Esteghamati, Alireza; Vigneron, C.; Nakhjavani, Manouchehr

doi:10.1684/mrh.2015.0392

Cited by 14 publications

(22 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Generally, obesity is associated with micronutrient deficiency, and it was shown that hypomagnesemia frequently occurs in obese women [ 25 ]. Low Mg levels in AF are associated with pregnancy complications such as preeclampsia or gestational diabetes, and overweight and obese women are at higher risk of developing these diseases [ 26 , 27 ]. In pregnant women, the BMI is usually inversely correlated with serum Cu level, although a positive correlation was observed between Cu concentration in the AF and fetal development [ 6 ].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Essential and Toxic Elements in Amniotic Fluid and Maternal Serum at Birth

Kocyłowski

Grzesiak

Gaj

et al. 2018

Biol Trace Elem Res

View full text Add to dashboard Cite

The objective of this study was to determine the concentration and the reference ranges of essential and toxic elements in amniotic fluid (AF) and maternal serum (MS) at birth. This study was conducted among 175 healthy pregnant Caucasian European women aged 18-42. AF and maternal blood samples were collected during delivery. An inductively coupled plasma mass spectrometry (ICP-MS) technique was used to determine the levels of Mg, Co, Cu, Zn, Sr, Cd, Ba, Pb, U, Ca, Cr, Al, Mn, V, Fe, As, Se and Sb in AF and MS. The range of reference values was calculated for all analyzed elements in the serum and AF. The mean concentrations of elements, except Pb, were generally higher in MS than in AF. Multiple regression analysis showed that the maternal/newborn body mass (MBM/NBM) ratio was a strong negative predictor (among maternal age and gravidity) of Mg concentration in amniotic fluid. In the serum, MBN/NBM ratio was a strong positive predictor of Cu concentration. Moreover, regression analysis showed that maternal age was an independent positive predictor of the Se level in maternal serum. The reference value ranges of 18 essential and toxic elements were established in AF and MS among a population of healthy pregnant Polish women at delivery. The level of Mg, Co, Cu, Ca and Se in AF and MS can be determined by maternal age and MBM/NBM ratio. These results can be useful in counseling individuals with pregnancies affected by exposure to one of the parameters under investigation.

show abstract

Section: Discussionmentioning

confidence: 99%

Evaluation of Essential and Toxic Elements in Amniotic Fluid and Maternal Serum at Birth

Kocyłowski

Grzesiak

Gaj

et al. 2018

Biol Trace Elem Res

View full text Add to dashboard Cite

show abstract

“…Magnesium deficiencies have been reported frequently in obesity [90][91][92][93][94][95][96][97][98][99][100][101]. Different causal factors between obesity and hypomagnesemia have been suggested.…”

Section: Low Magnesium Levels Are Often Seen In Obesitymentioning

confidence: 99%

“…Different causal factors between obesity and hypomagnesemia have been suggested. A relationship between insulin sensitivity and magnesium levels [94,98,102,103] and an inadequate intake due to a poor quality of the diet [104] were reported as key factors contributing to the association between obesity and low magnesium levels. This poor nutritional intake can further worsen in the presence of a restricted diet, if this is not supported by nutritional counseling.…”

Section: Low Magnesium Levels Are Often Seen In Obesitymentioning

confidence: 99%

“…In obesity, a chronic, low-grade inflammatory state is involved in the development of insulin resistance (IR), metabolic syndrome, and type II diabetes mellitus (T2DM) [107]. Currently, more awareness is also rising of the fact that low magnesium levels occur at higher frequency in diabetic patients [98]. The underlying mechanism has been elucidated to a certain extent.…”

Section: Low Magnesium Levels Lead To Insulin Resistancementioning

confidence: 99%

“…Next to that, magnesium is involved in insulin signaling. Lower intracellular pancreatic Mg levels result in a reduction of insulin secretion [98].…”

Section: Low Magnesium Levels Lead To Insulin Resistancementioning

confidence: 99%

See 2 more Smart Citations

The Use of Proton Pump Inhibitors May Increase Symptoms of Muscle Function Loss in Patients with Chronic Illnesses

Vinke

Wesselink

Orten-Luiten

et al. 2020

IJMS

View full text Add to dashboard Cite

Long-term use of proton pump inhibitors (PPIs) is common in patients with muscle wasting-related chronic diseases. We explored the hypothesis that the use of PPIs may contribute to a reduction in muscle mass and function in these patients. Literature indicates that a PPI-induced reduction in acidity of the gastrointestinal tract can decrease the absorption of, amongst others, magnesium. Low levels of magnesium are associated with impaired muscle function. This unwanted side-effect of PPIs on muscle function has been described in different disease backgrounds. Furthermore, magnesium is necessary for activation of vitamin D. Low vitamin D and magnesium levels together can lead to increased inflammation involved in muscle wasting. In addition, PPI use has been described to alter the microbiota’s composition in the gut, which might lead to increased inflammation. However, PPIs are often provided together with nonsteroidal anti-inflammatory drugs (NSAIDs), which are anti-inflammatory. In the presence of obesity, additional mechanisms could further contribute to muscle alterations. In conclusion, use of PPIs has been reported to contribute to muscle function loss. Whether this will add to the risk factor for development of muscle function loss in patients with chronic disease needs further investigation.

show abstract

Therapeutic Potential of Metals in Managing the Metabolic Syndrome

Parsanathan

Jagadeeshan

2021

Environmental Chemistry for a Sustainable World

View full text Add to dashboard Cite

Abdominal obesity and gestational diabetes: the interactive role of magnesium

Cited by 14 publications

References 0 publications

Evaluation of Essential and Toxic Elements in Amniotic Fluid and Maternal Serum at Birth

Evaluation of Essential and Toxic Elements in Amniotic Fluid and Maternal Serum at Birth

The Use of Proton Pump Inhibitors May Increase Symptoms of Muscle Function Loss in Patients with Chronic Illnesses

Therapeutic Potential of Metals in Managing the Metabolic Syndrome

Contact Info

Product

Resources

About