Abdominal manifestations of posttransplantation lymphoproliferative disorder.

Pickhardt, Perry J.; Siegel, Marilyn J.

doi:10.2214/ajr.171.4.9762986

Cited by 48 publications

(34 citation statements)

References 2 publications

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“…Recognition of clinically unsuspected disease of any nature is important, as early diagnosis may improve the response to therapy, especially in patients with PTLD (10,11,70). Distinguishing PTLD from other processes, such as infection, can be difficult, and the histopathologic form of PTLD (ie, polymorphic vs monomorphic) cannot be reliably ascertained from its imaging appearance (25,38,39,43). Therefore, tissue sampling is generally for definitive diagnosis.…”

Section: Goals Of Imagingmentioning

confidence: 99%

Posttransplantation Lymphoproliferative Disorder in Children: Clinical, Histopathologic, and Imaging Features

Pickhardt

Siegel²,

Hayashi³

et al. 2000

Radiology

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Posttransplantation lymphoproliferative disorder (PTLD) is a condition in patients who receive transplants in which chronic immunosuppression leads to an unregulated expansion of lymphoid cells; the condition ranges from hyperplasia to malignant lymphoid proliferation. Risk factors affecting the incidence of PTLD include allograft type, Epstein-Barr virus infection, and immunosuppression. In this article, we review the clinical, histopathologic, and imaging features of PTLD in children. Because PTLD can affect nearly any organ system, a wide variety of clinical manifestations is possible. The heterogeneous nature of the disease is also reflected on imaging studies. The goals of imaging in patients with PTLD are to detect disease, guide biopsy, and direct appropriate follow-up imaging rather than to establish a specific diagnosis. Because the clinical and imaging manifestations of PTLD are nonspecific and are not reliably predictive of histopathologic subtype, tissue biopsy is necessary for final diagnosis.

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Section: Goals Of Imagingmentioning

confidence: 99%

Posttransplantation Lymphoproliferative Disorder in Children: Clinical, Histopathologic, and Imaging Features

Pickhardt

Siegel²,

Hayashi³

et al. 2000

Radiology

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“…8,9 These lymphomas represent a spectrum of abnormal lymphocytic proliferation which is indistinguishable from non-Hodgkin lymphoma, usually of B-cell origin. 4,10 Despite the high frequency of intrathoracic manifestations of PTLD (7%-60% of all organtransplant patients), 11 the involvement of the thoracic wall is rare, and the development of such lesions has not previously been reported.…”

Section: Discussionmentioning

confidence: 99%

“…2,3,6 Most PTLDs are of B-cell origin, and their occurrence in the musculoskeletal system has rarely been reported in the literature. 3,4,7 To our knowledge, a posttransplant lymphoproliferative lesion of the thoracic cage has not been reported previously. This case report illustrates the presence of a pathologically proven B-cell lymphoma of the rib in a renal-transplant recipient.…”

mentioning

confidence: 80%

“…[1][2][3][4][5] These post transplant lymphoproliferative disorders (PTLDs) are reported by the Cincinnati Transplant Tumor Registry to represent up to 16% of all tumors among organtransplant patients as opposed to the 5% prevalence of tumors affecting the general population. 2,6 The occurrence of PTLD varies among the organ-transplant recipient population, and although any organ or system may be affected, PTLD tends to have a particular predilection for the allograft site.…”

mentioning

confidence: 99%

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Postlymphoproliferative Disorder Affecting Bone After A Renal Transplantation

Wessely¹,

Kettner²,

Pierre-Jerome³

2005

Journal of Manipulative and Physiological Therapeutics

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“…Three patterns of disease are documented [58,59]. Focal low-reflectivity areas with prominent vascularity within the liver parenchyma on B-mode imaging are the most common presentation and can be highlighted by the use of microbubble contrast enhancement.…”

Section: Posttransplant Lymphoproliferative Disorder (Ptld)mentioning

confidence: 99%

Microbubble contrast–enhanced ultrasound in liver transplantation

2004

Eur Radiol Suppl

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The use of liver transplantation for treatment of end-stage liver disease is now commonplace. The accurate assessment of the pretransplant candidate and long-term follow-up of the posttransplant patient is vital in ensuring that the limited resource of donor livers is appropriately used. Ultrasound is accepted as playing an important role in this process. The advent of microbubble contrast enhanced ultrasound provides new opportunities in terms of improving diagnostic accuracy and obviating more invasive investigations with their associated patient morbidity and mortality. We present the current and developing applications of microbubble contrast-enhanced ultrasound in the field of liver transplantation.

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Abdominal manifestations of posttransplantation lymphoproliferative disorder.

Cited by 48 publications

References 2 publications

Posttransplantation Lymphoproliferative Disorder in Children: Clinical, Histopathologic, and Imaging Features

Posttransplantation Lymphoproliferative Disorder in Children: Clinical, Histopathologic, and Imaging Features

Postlymphoproliferative Disorder Affecting Bone After A Renal Transplantation

Microbubble contrast–enhanced ultrasound in liver transplantation

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