Abdominal inflammatory myofibroblastic tumor

Fragoso, Ana Catarina; Eloy, Catarina; Estevão‐Costa, José; Campos, Miguel; Farinha, Nuno; Lopes, José Manuel

doi:10.1016/j.jpedsurg.2011.07.009

Cited by 31 publications

(18 citation statements)

References 40 publications

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“…The present study included 33.3% each of intrapulmonary and intra-abdominal locations followed by other locations. There was slight male predominance in the literature [10,11]; however, there was an equal incidence in each gender in the present study.…”

Section: Discussioncontrasting

confidence: 72%

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Clinicopathological Study of 18 Cases of Inflammatory Myofibroblastic Tumors with Reference to ALK-1 Expression: 5-Year Experience in a Tertiary Care Center

Telugu¹,

Prabhu

Kalappurayil

et al. 2017

J Pathol Transl Med

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BackgroundInflammatory myofibroblastic tumor is a histopathologically distinctive neoplasm of children and young adults. According to World Health Organization (WHO) classification, inflammatory myofibroblastic tumor is an intermediate-grade tumor, with potential for recurrence and rare metastasis. There are no definite histopathologic, molecular, or cytogenetic features to predict malignant transformation, recurrence, or metastasis.MethodsA 5-year retrospective study of histopathologically diagnosed inflammatory myofibroblastic tumors of various anatomic sites was conducted to correlate anaplastic lymphoma kinase-1 (ALK-1) expression with histological atypia, multicentric origin of tumor, recurrence, and metastasis. Clinical details of all the cases were noted from the clinical work station. Immunohistochemical stains for ALK-1 and other antibodies were performed. Statistical analysis was done using Fisher exact test.ResultsA total of 18 cases of inflammatory myofibroblastic tumors were found during the study period, of which 14 were classical. The female-male ratio was 1:1 and the mean age was 23.8 years. Histologically atypical (four cases) and multifocal tumors (three cases, multicentric in origin) were noted. Recurrence was noted in 30% of ALK-1 positive and 37.5% of ALK-1 negative cases, whereas metastasis to the lung, liver, and pelvic bone was noted in the ALK-1 positive group only.ConclusionsOverall, ALK-1 protein was expressed in 55.6% of inflammatory myofibroblastic tumors. There was no statistically significant correlation between ALK-1 expression, tumor type, recurrence and metastasis. However, ALK-1 immunohistochemistry is a useful diagnostic aid in the appropriate clinical and histomorphologic context.

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Section: Discussioncontrasting

confidence: 72%

“…Fragoso et al . [11] in 2011 stated that, although surgical resection is the preferred treatment for inflammatory myofibroblastic tumors, cases which are not amenable to surgical excision may be treated conservatively.…”

Section: Discussionmentioning

confidence: 99%

Clinicopathological Study of 18 Cases of Inflammatory Myofibroblastic Tumors with Reference to ALK-1 Expression: 5-Year Experience in a Tertiary Care Center

Telugu¹,

Prabhu

Kalappurayil

et al. 2017

J Pathol Transl Med

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“…Consequently, IMT can present with variable clinical symptoms according to the site of tumor origin. IMT is primarily a soft tissue tumor in young adults, most frequently occurring in the first two decades of life, but IMT may occur over a wider age range (3 weeks to 74 years) [2,5,6,7]. In Korea, there have been few reported infantile cases with the youngest patient being a 3 month-old infant with IMT at the transverse colon mesentery [8].…”

Section: Discussionmentioning

confidence: 99%

“…The etiology of IMT has not been fully described and is currently regarded as a specific neoplastic lesion with inflammatory sclerosing and fibrosing processes that may be recognized by cytogenetic aberrations such as ALK gene rearrangement, p53 mutation, and MDM2 expression [3,7]. Those associations may act as prognostic indicators that could suggest the need for aggressive clinical behavior, particularly when the IMT exhibits a combination of cellular atypia, ganglion-like cells, aneuploidy, and p53 overexpression [3,9].…”

Section: Discussionmentioning

confidence: 99%

Two Cases of Infantile Intra-abdominal Inflammatory Myofibroblastic Tumor

Kim

Cho

Kim

2014

Pediatr Gastroenterol Hepatol Nutr

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Inflammatory myofibroblastic tumor (IMT) is rare mesenchymal solid tumor that consists of proliferating myofibroblasts with an inflammatory infiltrate background. It has a very low prevalence in infants and occurs mainly in children and young adults. IMT are mainly located in the thoracic cavity, but intra-abdominal lesions are rare. IMT can exhibit locally aggressive neoplastic processes and metastases similar to malignancies, so, have clinical importance. Herein, we describe two infantile intra-abdominal IMT cases presenting with incidentally found palpable abdominal mass. A 4-month-old male infant had IMT at the ileal mesentery and a 5-month-old male infant had IMT at liver. Both cases were successfully treated by complete surgical resection without complication or recurrence. Considering the biological behavior of the intermediate type of neoplasm in IMT, we expect good survivals when achieving appropriate surgical resection without adjuvant therapy in infantile intra-abdominal IMT.

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“…Myofibroblastic tumors usually have capsules, with a clear boundary, and are rarely necrotic and mitotic. The only similarity is that vimentin, desmin, and SMA are also often positively expressed in myofibroblastic tumors 12,14. For the mesenchymal breast tumor, phyllodes tumor and metaplastic carcinoma should be considered first 14…”

Section: Discussionmentioning

confidence: 99%

Primary malignant fibrous histiocytoma of the breast: report of one case

Liu¹,

Zhao²,

Zhang³

et al. 2013

OTT

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Seven years ago, a 48-year-old female patient discovered a painless tumor in her right breast simply by chance. In the next year, the tumor increased significantly in size. At this point, the patient received a tumor resection, which was misdiagnosed as a benign mesenchymal tissue-originated tumor. Unfortunately, the tumor recurred just 10 days after resection. We subsequently resected the recurrent lesion and confirmed primary breast malignant fibrous histiocytoma. The tumor began to exhibit an unprecedented, massive, and uncontrolled growth, ulcerating soon after the operation. Treatment of the patient was limited by time. After the patient received a cycle of chemotherapy, she died of cachexia with the emergence of multiorgan metastasis 2 months after the operation.

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Abdominal inflammatory myofibroblastic tumor

Cited by 31 publications

References 40 publications

Clinicopathological Study of 18 Cases of Inflammatory Myofibroblastic Tumors with Reference to ALK-1 Expression: 5-Year Experience in a Tertiary Care Center

Clinicopathological Study of 18 Cases of Inflammatory Myofibroblastic Tumors with Reference to ALK-1 Expression: 5-Year Experience in a Tertiary Care Center

Two Cases of Infantile Intra-abdominal Inflammatory Myofibroblastic Tumor

Primary malignant fibrous histiocytoma of the breast: report of one case

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