Abdominal Aortic Diameter and the Risk for Asymptomatic Peripheral Arterial Disease in Patients with Type 2 Diabetes

Abstract

Peripheral arterial disease (PAD) is common among older people because it often results from atherosclerosis, which becomes more common with age. The disease is particularly common among people who have diabetes. Little information is available on the relation between abdominal aortic diameter and PAD in elderly patients with diabetes. This article studies the relationships between abdominal aortic diameter, PAD, and the cardiovascular risk factors in asymptomatic elderly patients suffering from type 2 diabetes mellitus. A case-control study was conducted on 90 participants aged 60 years and older divided into 60 cases (30 males and 30 females) and 30 age-matched healthy controls (15 males and 15 females). The relationships between the size of the abdominal aorta and ankle-brachial index (ABI), plasma cholesterol, triglycerides (TG), and high-sensitivity C-reactive protein were examined. Approximately, 15% of patients with diabetes had asymptomatic PAD. The patients with diabetes with PAD were of older age (70.4 ± 3.6 vs. 63.4 ± 3.9 years; p = 0.000), had larger abdominal aortic diameter (22.4 ± 3.08 vs. 18.7 ± 2 mm; p = 0.000), and higher CRP levels (8.3 ± 1.1 vs. 5.8 ± 2.2 mg/L; p = 0.002), while other variables revealed no significant difference. Abdominal aortic diameter correlated well with ABI measured by Doppler method in diabetic patients (r = - 0.471, p = 0.000). Older age and larger abdominal aorta are independent risk factors for asymptomatic PAD in the elderly with type 2 diabetes mellitus.

Early Prognostic Instrumental and Laboratory Biomarkers in Post-MI

“…Diabetic patients with low levels of hemoglobin (Hb) and high levels of triglycerides (TAG) may experience a significant increase in post-myocardial infarction (MI) myoglobin [31].…”

“…Myoglobin is a protein found in muscle tissue, and its levels can increase after a heart attack [31].…”

“…Elderly patients with concomitant diabetes mellitus often have a smaller aortic diameter and left ventricular size [31]. A case-control study found that abdominal aortic diameter was larger in diabetic patients with peripheral arterial disease than in healthy controls [31]. However, further research is needed to understand the exact relationship between abdominal aortic diameter and diabetes.…”

“…Diabetic patients with low levels of hemoglobin (Hb) and high levels of triglycerides (TAG) may experience a significant increase in post-myocardial infarction (MI) myoglobin [31]. Myoglobin is a protein found in muscle tissue, and its levels can increase after a heart attack [31].…”