Abdominal Aortic Calcification in Living Kidney Donors

Yoon, Young Eun; Han, Woong Kyu; Lee, H.H.; Chang, Moon Ho; Huh, Kyu Ha; Jung, Dae Chul; Kim, Yu Seun; Oh, Young Taek

doi:10.1016/j.transproceed.2016.02.037

Cited by 11 publications

(20 citation statements)

References 21 publications

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“…AAC can be detected using various complimentary methods, including plain lateral abdominal X‐ray films (straightforward, low radiation dose, only semiquantitative at best) and CT‐based examinations, with either manual or automatic algorithms to speedily and reproducibly detect and quantify calcified sections of the vessel walls . Given recent advancements in imaging devices, the AAC level can be calculated and quantified accurately and automatically …”

Section: Discussionmentioning

confidence: 99%

“…Using the Agatston method, the AAC volume was automatically calculated for calcifications located in the abdominal aorta (from the origin of the renal artery to the iliac bifurcation) with attenuation greater than the predefined 130 Hounsfield units level. Patients were divided into 2 groups according to the AAC level (<100 mm 3 or ≥100 mm 3 ) …”

Section: Methodsmentioning

confidence: 99%

“…Aortic calcification can be quantitatively measured on abdominal computed tomography (CT) as the aortic calcification index, a widely used measure that expresses calcification in 12 sectors as a percentage. In addition, abdominal aortic calcification (AAC) is easily evaluated on abdominal CT . AAC prevalence, patterns, and severity in the living kidney donor population have been reported .…”

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confidence: 99%

“…AAC prevalence, patterns, and severity in the living kidney donor population have been reported . Living donors with a high AAC level require close observation because such patients have a higher probability of delayed renal function recovery after donation . Furthermore, an initial report demonstrated that thoracic aortic calcification in renal transplantation recipients predicts both cardiovascular events and all‐cause mortality .…”

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confidence: 99%

“…(5) Living donors with a high AAC level require close observation because such patients have a higher probability of delayed renal function recovery after donation. (4) Furthermore, an initial report demonstrated that thoracic aortic calcification in renal transplantation recipients predicts both cardiovascular events and all-cause mortality. (6) However, the clinical implications of incidental AAC findings in liver transplantation (LT) have not been evaluated in terms of posttransplantation survival from complications.…”

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Impact of Abdominal Aortic Calcification Among Liver Transplantation Recipients

et al. 2019

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Abdominal aortic calcification (AAC) is known as a risk factor of coronary artery disease, stroke, hyperphosphatemia, chronic inflammation, diabetes, and decreased estimated glomerular filtration rate. However, the clinical implications of incidental AAC findings in liver transplantation have not been evaluated in terms of post-transplantation survival and complications. Therefore, we analyzed the relationships between the AAC level and the outcomes following liver transplantation. A total of 156 consecutive patients who underwent liver transplantation between January 2007 and December 2014 were divided into two groups according to their AAC level (< or ≥ 100 mm ), as calculated using the Agatston method. Even after propensity matching, the survival time was significantly longer in the low AAC group compared to that in the high AAC group (median survival time, 4.5 vs 3.0 years, p =0.004). A multivariate analysis identified high AAC level (hazard ratio, 2.2) and old donor age (hazard ratio, 2.2) as prognostic factors for overall survival. In conclusion, high AAC is an independent unfavorable prognostic factor in liver transplantation. This article is protected by copyright. All rights reserved.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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Impact of Abdominal Aortic Calcification Among Liver Transplantation Recipients

et al. 2019

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Impact of abdominal aortic calcification on clinical outcomes following initial hepatectomy for hepatocellular carcinoma: A retrospective cohort study

Imaoka

Ohira

Sato

et al. 2021

Annals of Gastroent Surgery

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Aim The clinical impact of abdominal aortic calcification (AAC) in patients who undergo hepatectomy for hepatocellular carcinoma (HCC) is unknown. Methods To evaluate the impact of AAC on clinical outcomes, we analyzed 203 patients who underwent hepatectomy for HCC between 2010 and 2013. Results Kaplan–Meier survival curve analysis showed significantly worse overall survival (OS) in the high AAC group than in the low AAC group. The recurrence‐free survival (RFS) was also significantly worse in the high AAC group. In the multivariate analysis, high AAC (hazard ratio [HR], 2.51; 95% confidence interval [CI], 1.24–5.09; P = .01) was an independent risk factor for poor OS after hepatectomy for HCC. High AAC was also an independent risk factor for poor RFS (HR, 1.69; 95% CI, 1.04–2.76; P = .04). Conclusions Abdominal aortic calcification had a strong relationship with poor OS and RFS after hepatectomy for HCC. We suggest that AAC had a relationship with smoking and diabetes; therefore, AAC could reflect a surrogate for older age, worse health status, and inflammatory score.

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Calcification of the visceral aorta and celiac trunk is associated with renal and allograft outcomes after deceased donor liver transplantation

et al. 2022

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Purpose Atherosclerosis affects clinical outcomes in the setting of major surgery. Here we aimed to investigate the prognostic role of visceral aortic (VAC), extended visceral aortic (VAC+), and celiac artery calcification (CAC) in the assessment of short- and long-term outcomes following deceased donor orthotopic liver transplantation (OLT) in a western European cohort. Methods We retrospectively analyzed the data of 281 consecutive recipients who underwent OLT at a German university medical center (05/2010–03/2020). The parameters VAC, VAC+, or CAC were evaluated by preoperative computed tomography-based calcium quantification according to the Agatston score. Results Significant VAC or CAC were associated with impaired postoperative renal function (p = 0.0016; p = 0.0211). Patients with VAC suffered more frequently from early allograft dysfunction (EAD) (38 vs 26%, p = 0.031), while CAC was associated with higher estimated procedural costs (p = 0.049). In the multivariate logistic regression analysis, VAC was identified as an independent predictor of EAD (2.387 OR, 1.290–4.418 CI, p = 0.006). Concerning long-term graft and patient survival, no significant difference was found, even though patients with calcification showed a tendency towards lower 5-year survival compared to those without (VAC: 65 vs 73%, p = 0.217; CAC: 52 vs 72%, p = 0.105). VAC+ failed to provide an additional prognostic value compared to VAC. Conclusion This is the first clinical report to show the prognostic role of VAC/CAC in the setting of deceased donor OLT with a particular value in the perioperative phase. Further studies are warranted to validate these findings. Graphical abstract CT computed tomography, OLT orthotopic liver transplantation

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Abdominal Aortic Calcification in Living Kidney Donors

Cited by 11 publications

References 21 publications

Impact of Abdominal Aortic Calcification Among Liver Transplantation Recipients

Impact of Abdominal Aortic Calcification Among Liver Transplantation Recipients

Impact of abdominal aortic calcification on clinical outcomes following initial hepatectomy for hepatocellular carcinoma: A retrospective cohort study

Calcification of the visceral aorta and celiac trunk is associated with renal and allograft outcomes after deceased donor liver transplantation

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