Abdominal aortic aneurysm in women

Lederle, Frank A.; Johnson, Gary R.; Wilson, Samuel E.

doi:10.1067/mva.2001.115275

Cited by 217 publications

(151 citation statements)

References 20 publications

(21 reference statements)

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“…We have summarized these studies in Table I. Three studies found that the hazard ratio having an AAA was higher among female than male smokers, 11,12,15 1 study found statistically undistinguishable odds ratio (OR) for AAA among ever-smoking men and women, 10 and another study showed that the risk for AAA among current smokers was higher in men than in women. 13 In conclusion, smoking appears to be a stronger risk factor for AAA in women.…”

Section: Human Aaa Studies Risk Factors For Aaa In Men and Womenmentioning

confidence: 99%

Sex Differences in Abdominal Aortic Aneurysm: The Role of Sex Hormones

Makrygiannis

Courtois

Drion

et al. 2014

Annals of Vascular Surgery

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Abdominal aortic aneurysm (AAA) is a complex multifactorial disease with genetic and environmental components. AAA is more common in men, whereas women have a greater risk of rupture and more frequently have concomitant thoracic aortic aneurysms. Moreover, women are diagnosed with AAA about 10 years later and seem to be protected by female sex hormones. In this MEDLINE-based review of literature, we examined human and animal in vivo and in vitro studies to further deepen our understanding of the sexual dimorphism of AAA. We focus on the role of sex hormones during the formation and growth of AAA. Endogenous estrogens and exogenous 17b-estradiol were found to exert favorable actions protecting from AAA in animal models, whereas exogenous hormone replacement therapy in humans had inconclusive results. Androgens, known to have detrimental effects in the vasculature, in sufficient levels maintain the integrity of the aortic wall through their anabolic actions and act differentially in men and women, whereas lower levels of testosterone have been associated with AAA in humans. In conclusion, sex differences remain an important area of AAA research, but further studies especially in humans are needed. Furthermore, differential molecular mechanisms of sex hormones constitute a potential therapeutic target for AAA.

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Section: Human Aaa Studies Risk Factors For Aaa In Men and Womenmentioning

confidence: 99%

Sex Differences in Abdominal Aortic Aneurysm: The Role of Sex Hormones

Makrygiannis

Courtois

Drion

et al. 2014

Annals of Vascular Surgery

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“…Some family members, if aged Ն50 years, were examined by ultrasonography and were identified as affected if the infrarenal aortic diameter was Ն3.0 cm, a cutoff point used previously. 14 Occurrences of isolated iliac artery or other aneurysms (such as thoracic or thoracoabdominal) were noted but were not included in the study. All families were white: 42 Canadian, 36 Dutch, 23 Belgian, 10 American, 3 British, 3 Finnish, 1 Italian, and 1 Swedish.…”

Section: Subjects and Phenotypingmentioning

confidence: 99%

“…An accepted definition of arterial aneurysm 10 was used. [12][13][14] Patients were identified from surgery records at vascular surgery units and were then contacted; consent was obtained, and family histories were collected. A certified vascular surgeon led the effort to identify AAA patients and affected family members.…”

Section: Subjects and Phenotypingmentioning

confidence: 99%

Genome Scan for Familial Abdominal Aortic Aneurysm Using Sex and Family History as Covariates Suggests Genetic Heterogeneity and Identifies Linkage to Chromosome 19q13

Shibamura

Olson

Keulen³

et al. 2004

Circulation

117

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Background-Abdominal aortic aneurysm (AAA) is a relatively common disease, with 1% to 2% of the population harboring aneurysms. Genetic risk factors are likely to contribute to the development of AAAs, although no such risk factors have been identified. Methods and Results-We performed a whole-genome scan of AAA using affected-relative-pair (ARP) linkage analysis that includes covariates to allow for genetic heterogeneity. We found strong evidence of linkage (logarithm of odds [LOD] scoreϭ4.64) to a region near marker D19S433 at 51.88 centimorgans (cM) on chromosome 19 with 36 families (75 ARPs) when including sex and the number of affected first-degree relatives of the proband (N aff ) as covariates. We then genotyped 83 additional families for the same markers and typed additional markers for all families and obtained a LOD score of 4.75 (Pϭ0.00014) with sex, N aff , and their interaction as covariates near marker D19S416 (58.69 cM).We also identified a region on chromosome 4 with a LOD score of 3.73 (Pϭ0.0012) near marker D4S1644 using the same covariate model as for chromosome 19. Conclusions-Our results provide evidence for genetic heterogeneity and the presence of susceptibility loci for AAA on chromosomes 19q13 and 4q31.

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“…31,32 The relatively recent Aneurysm Detection and Management (ADAM) study of 16 Veterans Affairs medical centers is one of the largest prospective screening studies. 33 More than 125 000 patients from 50 to 79 years of age, the vast majority of whom were men, were screened by using the definition of AAA as Ն3.0 cm. Prevalence was 4.3% and 1.0% for men and women, respectively.…”

Section: Aortic Atherosclerotic Diseasementioning

confidence: 99%