Abdominal adiposity is associated with fatty acid desaturase activity in boys: Implications for C-reactive protein and insulin resistance

Saito, Emiko; Okada, Tomoo; Abe, Yuriko; Odaka, Minako; Kuromori, Yuki; Iwata, Fujihiko; Hara, Mitsuhiko; Mugishima, Hideo; Kitamura, Yohei

doi:10.1016/j.plefa.2013.01.005

Cited by 26 publications

(21 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A cross-sectional relation with D6D was also observed in Japanese school children (22) and in US adolescents (47). In the latter study agreeing with our results no association of D5D with HDL z-score was observed while two Japanese studies found a positive association in boys (22) or in all children (1).…”

Section: Desaturase Activity and Dyslipidemiasupporting

confidence: 91%

“…Since high D9D activity seems to play a crucial role in obesity development a positive association of D9D with the T0 and T1 BMI was expected and confirmed in our study. As expected, our cross-sectional analysis showed a positive association of D6D and a negative association of D5D with the BMI z-score confirming results from Japanese studies in school children in which such associations were also found for weight status (21) and waist-to-height ratio (WtHR) (21,22). Also in 264 adolescents (mean age 15 years), D6D was positively associated with obesity (47).…”

Section: Desaturase Activity and Weight Statussupporting

confidence: 90%

“…In 237 Japanese school children, D6D was positively associated while D5D was negatively associated with insulin and HOMA index in a cross-sectional analysis (22) confirming similar results in Japanese adults (8). Another Japanese study found a positive correlation between D6D with ⌬ BMI z-score ϭ T1 BMI z-score -T0 BMI z-score).…”

Section: Desaturase Activity and Insulin Resistancesupporting

confidence: 71%

“…Similar associations reported so far in adults on the role of D9D, D6D and D5D in obesity and related metabolic disturbances have been confirmed in school children (1,2,22). However, data in younger children and longitudinal data from a large sample are missing.…”

supporting

confidence: 70%

“…While D6D is positively associated with obesity and metabolic risk factors like dyslipidemia and insulin resistance, D5D is negatively related (21,22). The underlying mechanisms are still not well understood.…”

mentioning

confidence: 99%

See 4 more Smart Citations

Desaturase Activity Is Associated With Weight Status and Metabolic Risk Markers in Young Children

Wolters

Schlenz

Börnhorst

et al. 2015

The Journal of Clinical Endocrinology &Amp; Metabolism

View full text Add to dashboard Cite

show abstract

Section: Desaturase Activity and Dyslipidemiasupporting

confidence: 91%

Section: Desaturase Activity and Weight Statussupporting

confidence: 90%

Section: Desaturase Activity and Insulin Resistancesupporting

confidence: 71%

supporting

confidence: 70%

mentioning

confidence: 99%

See 3 more Smart Citations

Desaturase Activity Is Associated With Weight Status and Metabolic Risk Markers in Young Children

Wolters

Schlenz

Börnhorst

et al. 2015

The Journal of Clinical Endocrinology &Amp; Metabolism

View full text Add to dashboard Cite

show abstract

Delta-5 and Delta-6 Desaturases: Crucial Enzymes in Polyunsaturated Fatty Acid-Related Pathways with Pleiotropic Influences in Health and Disease

Tosi

Sartori

Guarini

et al. 2014

Advances in Experimental Medicine and Biology

137

164

View full text Add to dashboard Cite

Endogenous Production of Long-Chain Polyunsaturated Fatty Acids and Metabolic Disease Risk

Murff

Edwards

2014

Curr Cardiovasc Risk Rep

View full text Add to dashboard Cite

Long chain polyunsaturated fatty acids (PUFAs) are important structural components of cellular membranes and are converted into eicosanoids which serve various biological roles. The most common dietary n-6 and n-3 PUFAs are linoleic acid and α-linoleic acid, respectively. These 18-carbon chain fatty acids undergo a series of desaturation and elongation steps to become the 20-carbon fatty acids arachidonic acid and eicosapentaenoic acid, respectively. Evidence from genome wide association studies has consistently demonstrated that plasma and tissue levels of the n-6 long-chain PUFA arachidonic acid and to a lesser extent the n-3 long-chain PUFA eicosapentaenoic acid, are strongly influenced by variation in fatty acid desaturase-1,-2, and elongation of very long chain fatty acid genes. Studies of functional variants in these genes, as well as studies in which desaturase activity has been indirectly estimated by fatty acid product-toprecursor ratios, have suggested that endogenous capacity to synthesize long-chain PUFAs may be associated with metabolic diseases such as diabetes mellitus. Interventional studies are starting to tease out the complicated relationship between dietary intakes of specific fatty acids, variation in desaturase and elongase genes and tissue levels of long chain PUFAs. Thus future studies of dietary PUFA interventions designed to reduce inflammatory and metabolic diseases will need to carefully consider how an individual's genetically-determined endogenous long-chain PUFA synthesis capacity might modify therapeutic response.

show abstract

Abdominal adiposity is associated with fatty acid desaturase activity in boys: Implications for C-reactive protein and insulin resistance

Cited by 26 publications

References 30 publications

Desaturase Activity Is Associated With Weight Status and Metabolic Risk Markers in Young Children

Desaturase Activity Is Associated With Weight Status and Metabolic Risk Markers in Young Children

Delta-5 and Delta-6 Desaturases: Crucial Enzymes in Polyunsaturated Fatty Acid-Related Pathways with Pleiotropic Influences in Health and Disease

Endogenous Production of Long-Chain Polyunsaturated Fatty Acids and Metabolic Disease Risk

Contact Info

Product

Resources

About