Abdominal Abscess due to Leuconostoc Species in a Liver Transplant Recipient

Montejo, Miguel; Grande, C. Camarena; Valdivieso, A.; Testillano, M.; Minguillan, J.; Aguirrebengoa, Koldo; Urbina, J. Ortiz de

doi:10.1053/jinf.2000.0705

Cited by 19 publications

(18 citation statements)

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“…infection (Montejo et al, 2000;Espinoza et al, 1997;Giraud et al, 1993;Yamazaki et al, 2009). We noticed that most case reports did not describe any molecular methods to identify the Leuconostoc spp.…”

Section: Discussionmentioning

confidence: 89%

“…With the increasing use of vancomycin in clinical practice, some new vancomycin-resistant pathogenic bacteria are likely to appear. Compromised immunity (Montejo et al, 2000;Espinoza et al, 1997;Ferrer et al, 1995), use of vancomycin, parenteral nutrition (Bou et al, 2008) and contaminated surgical implanted devices, such as central venous catheters (Bou et al, 2008), have been considered as risk factors for Leuconostoc spp. infection, although Leuconostoc infections have also been documented in otherwise healthy patients.…”

Section: Discussionmentioning

confidence: 99%

“…However, to date, no deaths related to Leuconostoc spp. infection have been reported (Facklam & Elliott, 1995;Bernaldo de Quiró s et al, 1991;Montejo et al, 2000;Espinoza et al, 1997;Giraud et al, 1993;Yamazaki et al, 2009). Some Enterococcus spp.…”

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confidence: 99%

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A mixed infection of Leuconostoc lactis and vancomycin-resistant Enterococcus in a liver transplant recipient

Deng

Zhang

Xie

et al. 2012

Journal of Medical Microbiology

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Bacterial infection in patients who have undergone liver transplantation is a major complication of the procedure. Leuconostoc spp. are important pathogenic bacteria in individuals with poor immune function, especially transplant patients. In this report, we describe the case of a 45-yearold Asian male liver transplant recipient who was initially preliminarily diagnosed with infection with Leuconostoc pseudomesenteroides by using the microbial tests of the VITEK 2 system and the aesculin hydrolysis test, and with vancomycin-resistant Enterococcus. Subsequently, the Leuconostoc isolate was identified as Leuconostoc lactis by 16S rRNA gene partial sequencing. In this paper, we discuss our identification of L. lactis based on physiological characteristics and molecular methodology. Accurate identification of these infections is important for the outcome; use of 16S rRNA gene sequence analysis offers a rapid and precise diagnostic approach. Administration of the drug linezolid may be useful for the treatment of both Leuconostoc spp. and vancomycin-resistant Enterococcus infections. We suggest that clinical analysts should use molecular methods in addition to biochemical tests in order to identify Leuconostoc at the species level more accurately. IntroductionBacterial infection is a major complication after liver transplantation and the incidence is around 48 %. Vancomycin prophylaxis against Gram-positive bacteraemia following transplantation may prevent infection. However, with the increasing use of vancomycin in clinical practice, new vancomycin-resistant pathogenic bacteria are likely to appear.Leuconostoc spp. are Gram-positive, catalase-negative bacteria and are intrinsically resistant to vancomycin (Facklam & Elliott, 1995;Bernaldo de Quiró s et al., 1991). As a consequence of their irregular coccoid morphology, they used to be listed as members of the Streptococcaceae, but are now recognized as Leuconostocaceae and are placed within the order Lactobacillales. These bacteria are found in the environment, e.g. on vegetables and in dairy and other fermented products, but are known to occasionally cause infection in humans. Subsequent to 1985, several infections that resulted from Leuconostoc spp., namely Leuconostoc mesenteroides and Leuconostoc pseudomesenteroides, have been reported (Handwerger et al., 1990;Bernaldo de Quiró s et al., 1991;Dhodapkar & Henry, 1996). Most reported cases were bloodstream infections; however, these bacteria are also a cause of meningitis, pneumonia, endocarditis, pleural empyema, osteomyelitis or urinary tract infections. However, to date, no deaths related to Leuconostoc spp. infection have been reported (Facklam & Elliott, 1995;Bernaldo de Quiró s et al., 1991;Montejo et al., 2000;Espinoza et al., 1997;Giraud et al., 1993;Yamazaki et al., 2009). Some Enterococcus spp. are commensal organisms in the intestine. Furthermore, vancomycin-resistant enterococci (VRE) are recognized as some of the most significant nosocomial pathogens in the world because of their rapid spread, high mor...

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Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 99%

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A mixed infection of Leuconostoc lactis and vancomycin-resistant Enterococcus in a liver transplant recipient

Deng

Zhang

Xie

et al. 2012

Journal of Medical Microbiology

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“…To our knowledge, this is the first report of brain abscesses caused by Leuconostoc, although other types of central nervous system infection (5, 6, 9) and abscesses at other sites (2,15,20) have been reported. Leuconostoc infections are generally described for patients with underlying disease and impaired immunity of some type (7,8,14).…”

mentioning

confidence: 76%

Molecular Identification of Leuconostoc mesenteroides as a Cause of Brain Abscess in an Immunocompromised Patient

Albanese¹,

Spanu

Sali

et al. 2006

J Clin Microbiol

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“…Se ha descrito bacteriemia en un gran quemado, portador de CVC y con AEC . Se ha podido aislar de hemocultivos, líquido pleural, LCR, líquido ascítico, orina, tejido óseo y en muestras obtenidas por lavado broncoalveolar 14,21-25. Puede producir meningitis 26,27 , ventriculitis 28 , peritonitis 29 , abscesos hepáticos 30 , abscesos mamarios 31 , infección de origen dental 32 , infección asociada a caté-ter 23 , osteomielitis 33,34 , endoftalmitis 35 , neumonía 14 , endocarditis 36 , bacteriemia 37 y síndromes sépticos 3 . Está descrito un brote nosocomial por este agente en pacientes críticos 38 y casos de infección urinaria asociada a catéter urinario permanente 39,40 .…”

Section: Estudios Con Secuenciación De Los Fragmentos 16s Rarn Y 23s unclassified

Infección por Leuconostoc en pacientes con síndrome de intestino corto, nutrición parenteral y alimentación enteral continua

et al. 2006

Rev. chil. infectol.

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Abdominal Abscess due to Leuconostoc Species in a Liver Transplant Recipient

Cited by 19 publications

References 4 publications

A mixed infection of Leuconostoc lactis and vancomycin-resistant Enterococcus in a liver transplant recipient

A mixed infection of Leuconostoc lactis and vancomycin-resistant Enterococcus in a liver transplant recipient

Molecular Identification of Leuconostoc mesenteroides as a Cause of Brain Abscess in an Immunocompromised Patient

Infección por Leuconostoc en pacientes con síndrome de intestino corto, nutrición parenteral y alimentación enteral continua

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