ABCL-365: Non-Hodgkin Lymphoma Developed in the Clinical Course of a Child with Wiskott-Aldrich Syndrome

Tomacinschii, Cristina; Sciuca, Svetlana; Selvestru, Rodica; Popovici, Eugen; Golban, Rodica; Tomacinschii, Victor; Cantir, Evghenii

doi:10.1016/s2152-2650(21)01895-4

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2023

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“…Conform USIDNET (Rețeaua de imunodeficiențe primare din Statele Unite) între 2003 și 2015, pacienții au prezentat un exces de risc relativ pentru malignități de 1,42 ori în comparație cu populația generală ajustată în funcție de vârstă [6]. Printre tumorile întâlnite în imunodeficiențele primare cele mai frecvente au fost cele hematologice, preponderant limfoide, cu o creștere semnificativă ale limfomului la bărbați (de 10 ori) cât și la femei (de 8,34 ori) [6,13].…”

Section: Introducereunclassified

Hematological malignancies in children with primary immunodeficiency

Sciuca,

Tomacinschi,

Selevestru

2023

BulMed

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Primary immunodeficiencies (PIDs) represent a heterogeneous group of congenital disorders, often associated with specific genetic mutations. They are characterized by a varied spectrum of clinical manifestations, malignant tumors being the second cause of death among patients with primary immunodeficiencies after infections. The article presents the clinical case of a 13-year-old patient with a history of severe ataxia, telangiectasias, frequent respiratory infections, and cervical and submandibular lymphadenopathy diagnosed with IDP Ataxia Telangiectasia based on ESID criteria. Against the background of IDP, he is also diagnosed with Non-Hodgkin’s lymphoma.

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Section: Introducereunclassified