ABCG5/ABCG8 in cholesterol excretion and atherosclerosis

Yu, Xiaohua; Qian, Kun; Jiang, Na; Zheng, Xi-Long; Cayabyab, Francisco S.; Tang, Chao-Ke

doi:10.1016/j.cca.2013.11.010

Cited by 153 publications

(100 citation statements)

References 64 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Consistent with these functions, ABCG5 and ABCG8 are expressed almost exclusively on the brush border membranes of enterocytes and in the canalicular membranes of hepatocytes (Yu et al, 2014). LXRα is regarded as the major regulator of ABCG5 and ABCG8 mRNA expression, and the LXR agonist T0901317 markedly upregulates ABCG5 and ABCG8 expression in the small intestine and liver of wild type but not LXRα knockout mice (GonzalezGranillo et al, 2012;van der Veen et al, 2007).…”

Section: Abcg5 and Abcg8mentioning

confidence: 99%

“…Two additional members of the ABC transporter family, ABCG5 and ABCG8, form the obligate heterodimer that limits intestinal absorption and facilitates the biliary secretion of cholesterol and phytosterols (Graf et al, 2002;Yu et al, 2014). Consistent with these functions, ABCG5 and ABCG8 are expressed almost exclusively on the brush border membranes of enterocytes and in the canalicular membranes of hepatocytes (Yu et al, 2014).…”

Section: Abcg5 and Abcg8mentioning

confidence: 99%

See 1 more Smart Citation

Liver X Receptors and their Agonists: Targeting for Cholesterol Homeostasis and Cardiovascular Diseases

Ma¹,

Deng²,

Hu³

et al. 2017

Current Issues in Molecular Biology

View full text Add to dashboard Cite

Liver X receptors α (LXRα) and β (LXRβ) are essential for protection against cardiovascular diseases. LXRs are members of the nuclear receptor superfamily of DNA-binding transcription factors and act as sensors of cholesterol homeostasis. In this review, we introduce LXRs and briefly describe the roles of LXRs in reverse cholesterol transport and trans-intestinal cholesterol efflux. We discuss LXR agonists and the downstream genes of LXRs that are involved in the regulation of cholesterol transport. In addition, we describe the cardioprotective effects of LXRs against atherosclerosis, myocardial ischemia/reperfusion injury, diabetic cardiomyopathy, and myocardial hypertrophy. Finally, we expand our discussion to the actions of LXRs in atherosclerosis and suggest several potential research avenues that may be of interest to clinicians and basic scientists. The information included herein may be useful for the design of future experimental research studies and may advance the investigation of LXRs as therapeutic targets.

show abstract

Section: Abcg5 and Abcg8mentioning

confidence: 99%

Section: Abcg5 and Abcg8mentioning

confidence: 99%

Liver X Receptors and their Agonists: Targeting for Cholesterol Homeostasis and Cardiovascular Diseases

Ma¹,

Deng²,

Hu³

et al. 2017

Current Issues in Molecular Biology

View full text Add to dashboard Cite

show abstract

“…Specifically, mutations in ABCG5 or ABCG8 impede dimerization of the gene expression products, sterolin 1 or 2, respectively, resulting in prevention of expression at the cellular lumen of canalicular hepatocytes and intestinal brush border enterocytes, where they normally function as efflux pumps to extrude phytosterols into bile for eventual incorporation into chylomicrons and subsequent elimination. 26,27 Diagnosis is validated via plasma sterol profiling by gas chromatography to determine levels of sitosterol, campesterol and stigmasterol. [2][3][4] Only few case reports in patients where sitosterolemia was recognized as a cause of PHT2HC have been previously reported including three Japanese reports of two unrelated subjects and one pair of sisters, [19][20][21] and one report on two unrelated Chinese patients, 22 with a history of xanthoma development during childhood.…”

mentioning

confidence: 99%

Sitosterolemia Presenting as Pseudohomozygous Familial Hypercholesterolemia

Renner¹,

Connor

Steiner

2016

Clin Med Res

View full text Add to dashboard Cite

A young girl, age 8.5 years, presented with profound hypercholesterolemia and early xanthomatosis, suggesting homozygous familial (or type II) hypercholesterolemia. The patient's low density lipoprotein (LDL) receptor function and parental lipoprotein profiles were determined to be normal, prompting revision of the initial diagnosis to pseudohomozygous familial hypercholesterolemia. When she subsequently presented with giant platelets, the case was presented to colleagues on an electronic mailing list. It was recommended that plasma and sterol analysis be performed, which led to a diagnosis of sitosterolemia. The presentation of profound hypercholesterolomia in childhood that ultimately is not attributed as due to homozygous or compound heterozygous defects in the LDL receptor gene has been termed pseudohomozygous familial (or type II) hypercholesterolemia (PHT2HC). Patients diagnosed with PHT2HC subsequently confirmed to have sitosterolemia have been previously reported only rarely. The challenge of achieving accurate specific diagnosis and appropriate workup for these conditions in children is discussed in the context of this rare case and review of the historical literature concerning these conditions.

show abstract

“…As principais rotas de efluxo do colesterol hepático são o colesterol livre secretado na bile, o colesterol convertido em sais e ácidos biliares e o secretado por meio do VLDLc (HARVEY e FERRIER, 2012;HSIEH et al 2014;YU et al, 2014).…”

Section: Metabolismo Do Colesterolunclassified

“…(ABCG5) e G8 (ABCG8) inibe a absorção de colesterol e esteróis vegetais da dieta mediando o efluxo destes esteróis a partir dos enterócitos de volta ao lúmen intestinal e promovendo a secreção eficiente de colesterol e esteróis vegetais de hepatócitos para a bile (YU et al, 2014 Ésteres de colesterol são, então, conduzidos à biogênese dos quilomícrons (WANG, 2007;HARVEY e FERRIER, 2012;CASTRO-TORRES et al, 2014).…”

Section: Metabolismo Do Colesterolunclassified

Biodisponibilidade de peptídeos do feijão caupi (Vigna unguiculata L.Walp) e o metabolismo do colesterol

Salvador¹

View full text Add to dashboard Cite

A Deus, pela vida e pela capacidade de aprender e de buscar ser melhor a cada dia.A toda a minha família, pelo amor, incentivo e apoio, cada um a seu modo. Em especial a minha mãe Carman, pelo exemplo de garra e força de vontade e ao meu irmão Adriano, pelo exemplo de determinação e superação.Ao Professor José Alfredo, pela oportunidade e por todos os ensinamentos ao longo desses anos.Aos membros da banca examinadora: Daniel Carvalho Pimenta, Elizabeth Torres, Marília Cerqueira Leite Seelaender e Valéria Sutti Nunes pelas valiosas contribuições. Ainda à Professora Elizabeth pela disponibilidade do Laboratório de Bromatologia e aos pesquisadores Daniel e Valéria, pela parceria com análises e auxílio ao longo do trabalho.As Doutoras Geni e Liania, pelo suporte técnico nos laboratórios, pelo carinho e auxílio em todos os campos da vida.À companheira de análises Rosana, pela amizade, apoio técnico e orientação ao longo de toda esta etapa.Aos colegas e amigos da FSP e de Sampa: Augusto Carioca, Áurea Bombo, Cláudia Tramontt, Érica Oki, Érica Siguemoto, Flávia de Conti, Glória Guizellini, Jéssica Aragão, Kamila Gabe, Iara, Joice Castro, Lucile Matsumoto, Manuela Lopes, Maria Carolina Von Atzingen, Mariana Séfora, Marina Norde, Sebastião Bastos, Simone Silva, Társis Maia e Thaíse Mendes, pelos bons momentos e por proporcionarem tornar essa etapa ainda mais enriquecedora e feliz.Aos amigos e colegas de laboratório: Amanda Carlos, Camila Olivieri, Cintia Silva, Gustavo Fontanari, Marcelo Marques, Nara Letícia Zandonadi e Rosana Soares, por todo o carinho, colaboração e aprendizado compartilhado. A CAPES, pela concessão da bolsa de doutorado."É necessário aprender a ser grande, mas antes deverá medir-se a própria pequenez, pois esta seria uma forma de ver a si mesmo sobre a palma da mão e ver, também, de que modo esse pequeno ser pode ir crescendo, até assumir a estatura do gigante a que cada um aspira." The peptides identified from the protein hydrolysis of cowpea or from the plasma of the animals studied did not show similarities among the experiments or correspond to sequences previously identified for the cowpea from the database. CT, VLDL-c, HDL-c, TG, CH of hamsters were higher in groups H and I when compared to N; LDL-c was higher for I compared to the others; LH was higher in H compared to N, and I did not differ from the others; CF was higher for I compared to N, and H did not differ from the others. The expression of ABCA1 was higher for I than the others; LXRα was higher for I than H, but N did not differ from the others; SREBP2 was lower in H compared to the others; HMGCR was more expressed in N compared to the others, whereas the activity of this enzyme was higher in I when compared to N, and H did not differ from the others. Carlos Bernardo González PecotcheThere was no difference between groups regarding AB or expression of ABCG8 or AMPK. No expression results were obtained for LDLR, ABCG1 and ABCG5. Conclusion: Although previous research to this work evidenced the ability of the cowpea protein isolate to i...

show abstract

ABCG5/ABCG8 in cholesterol excretion and atherosclerosis

Cited by 153 publications

References 64 publications

Liver X Receptors and their Agonists: Targeting for Cholesterol Homeostasis and Cardiovascular Diseases

Liver X Receptors and their Agonists: Targeting for Cholesterol Homeostasis and Cardiovascular Diseases

Sitosterolemia Presenting as Pseudohomozygous Familial Hypercholesterolemia

Biodisponibilidade de peptídeos do feijão caupi (Vigna unguiculata L.Walp) e o metabolismo do colesterol

Contact Info

Product

Resources

About