ABCD: Alzheimer’s disease Biomarkers Comprehensive Database

Kumar, Ashwani; Bansal, Ankush; Singh, Tiratha Raj

doi:10.1007/s13205-019-1888-0

Cited by 3 publications

(3 citation statements)

References 36 publications

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“…One of the most complex organs in the body is the brain. Aging is a significant cause of neurological conditions like AD [10,11]. Most research into diseases caused by protein misfolding has been concentrated on the nervous system for many years.…”

Section: Diversity Of the Nervous Systemmentioning

confidence: 99%

Innate and adaptive glial cell responses in Alzheimer’s disease

Singh

2023

Explor Neuroprot Ther

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Alzheimer’s disease (AD), which affects around twenty-seven million people globally, is an aging-related neurodegenerative condition characterized by the extracellular deposition of misfolded amyloid-β (Aβ) peptides and the intracellular production of neurofibrillary tangles (NFTs) AD results from the death of certain groups of neurons in the brain while appearing to have no impact on neighboring neurons. It is progressive and incurable. Therefore, the pathophysiology of afflicted populations and the development of intervention measures to stop neuronal cell death have been the main areas of attention for delineating therapeutic options. Proinflammatory cytokines are responsible for the stimulation of inflammatory responses and are mostly generated by activated macrophages in the brain. This review discusses how glial cells and innate and adaptive immune responses have a critical role in AD. It also provides information about microglial activation through the cluster of differentiation 40 (CD40) ligation and CD40L. CD40L ligation of microglial CD40 results in a large increase in tumor necrosis factor-α (TNF-α) production. Cultured cortical neuronal injury is caused when microglia are activated by CD40 ligation in the presence of interferon-γ (IFN-γ). This injury is significantly reduced by blocking the CD40 pathway or neutralising TNF-α. The management of AD would require integrating all available information about the innate and adaptive immune response affecting AD-related neuronal death.

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Section: Diversity Of the Nervous Systemmentioning

confidence: 99%

Innate and adaptive glial cell responses in Alzheimer’s disease

Singh

2023

Explor Neuroprot Ther

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“…AD is the most common type of dementia, mainly afflicting aging population [56][57][58]. A major hypothesis for the disease pathology posits the accumulation of misfolded proteins, Amyloid β and Tau in the forebrain [59,60].…”

Section: Roles Of Hsp70 and Hsp90 In Neurogenerative Diseasesmentioning

confidence: 99%

HSP70 and HSP90 in neurodegenerative diseases

Gupta

Bansal

Hashimoto-Torii

2020

Neuroscience Letters

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Molecular chaperones have a role to stabilize proteins or assist them in reaching their native fold. Heat shock proteins (HSPs) are a family of molecular chaperons that protect proteins from cellular stress during the assembly of protein complexes and also prevent the proteins from aggregation and disassembly. The immediate increase of HSPs is crucial for cellular adaptation to environmental changes and protection of other proteins from denaturation, thereby maintaining the cellular homeostasis and increasing the longevity of an organism. HSP70 and HSP90 are the most studied HSPs in this very large HSP family. Notably, HSP90 also stabilizes the disease-related proteins in neurodegenerative disorders. Therefore, small molecules that inhibit the HSP90 but also increase the HSP70 has been tested as potential drugs for neurodegenerative disorders.

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“…In nano form, have recently attracted considerable attention as effective, environmentally sustainable, heterogeneous catalysts and have found immense applications in various organic transformations [11]. TiO2 and ZnO nanoparticles have been used in various fields, including optoelectronics, ferromagnetism, piezoelectric transducers, solar cells, gas sensors, etc [12,13]. These also possess antibacterial efficiencies and antioxidants.…”

Section: Introductionmentioning

confidence: 99%