ABCC8 mRNA expression is an independent prognostic factor for glioma and can predict chemosensitivity

Zhou, Kaijia; Liu, Yanwei; Zhao, Zheng; Wang, Yinyuan; Huang, Lijie; Chai, Rui‐Chao; Li, Guanzhang; Jiang, Tao

doi:10.1038/s41598-020-69676-7

Cited by 17 publications

(19 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Evaluation of the effects of genetic depletion of ABCC8 in mouse models of metastatic breast cancer on metastasis to the central nervous system is merited. ABCC8 has been identified as an independent prognostic factor in glioma, with patients whose tumors expressed high levels of ABCC8 mRNA possessing improved patient survival 8 , consistent with our findings in patients with breast cancer. ABCC8 mRNA primary tumor expression in glioma patients was predictive of sensitivity to temozolomide chemotherapy 8 .…”

Section: Discussionsupporting

confidence: 90%

“…ABCC8 has been identified as an independent prognostic factor in glioma, with patients whose tumors expressed high levels of ABCC8 mRNA possessing improved patient survival 8 , consistent with our findings in patients with breast cancer. ABCC8 mRNA primary tumor expression in glioma patients was predictive of sensitivity to temozolomide chemotherapy 8 . Modulation of ABCC8 expression may be relevant to the processes by which breast cancer cells exit the breast, enter the vasculature and/or lymphatics, reside in the lymph nodes, evade immune clearance, breach the blood-brain barrier and colonize the brain.…”

Section: Discussionsupporting

confidence: 90%

“…We performed Kaplan-Meier survival analysis 8 in 1402 breast cancer patients in total, to evaluate whether ABCC8 tumor expression was correlated with survival outcomes in breast cancer. We observed a statistically significant correlation between primary tumor expression of ABCC8 and overall survival in patients with breast cancer (Figure 2).…”

Section: Abcc8 Expression Is Significantly Correlated With Survival Outcomes In Human Breast Cancermentioning

confidence: 99%

See 2 more Smart Citations

ATP-binding cassette transporter sub-family C member 8, ABCC8, is a differentially expressed gene in brain metastatic human breast cancer.

Mamoor¹

2020

Preprint

View full text Add to dashboard Cite

Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). We mined published microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with brain metastasis in humans with metastatic breast cancer. We found that the ATP-binding cassette transporter sub-family C member 8, encoded by ABCC8, was among the genes whose expression was most different in the brain metastases of patients with metastatic breast cancer as compared to primary tumors of the breast. ABCC8 mRNA was present at increased quantities in brain metastatic tissues as compared to primary tumors of the breast. Importantly, expression of ABCC8 in primary tumors was significantly correlated with patient overall survival. Modulation of ABCC8 expression may be relevant to the biology by which tumor cells metastasize from the breast to the brain in humans with metastatic breast cancer.

show abstract

Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 90%

Section: Abcc8 Expression Is Significantly Correlated With Survival Outcomes In Human Breast Cancermentioning

confidence: 99%

See 1 more Smart Citation

ATP-binding cassette transporter sub-family C member 8, ABCC8, is a differentially expressed gene in brain metastatic human breast cancer.

Mamoor¹

2020

Preprint

View full text Add to dashboard Cite

show abstract

“…Tachon et al reported that the transcription factor Mesenchyme Homeobox 2 (MEOX2), a prognostic biomarker of LGG, is closely correlated to the overall survival (Tachon et al, 2019 ). Jiang et al further demonstrated that low expression of ATP binding cassette subfamily C member 8 (ABCC8) is an independent predictor of favorable prognosis in glioma patients (Zhou et al, 2020 ). In this study, we found that CFI is significantly upregulated in glioma tissues and strongly correlated with the prognosis of glioma patients in TCGA and CGGA cohorts.…”

Section: Discussionmentioning

confidence: 99%

A Candidate Prognostic Biomarker Complement Factor I Promotes Malignant Progression in Glioma

Cai

Qiu

Qian

et al. 2021

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

Objectives: Glioma is the most common and aggressive type of primary central nervous system (CNS) tumor in adults and is associated with substantial mortality rates. The aim of our study was to evaluate the prognostic significance and function of the complement factor I (CFI) in glioma.Materials and Methods: The expression levels of CFI in glioma tissues and the survival of the CFIhigh and CFIlow patient groups were analyzed using The Cancer Genome Atlas (TCGA) database and Genotype-Tissue Expression (GTEx). The correlation between CFI expression and clinicopathological features of glioma was determined by univariate and multivariate Cox regression analyses in the Chinese Glioma Genome Atlas (CGGA) database. The functional role of CFI in glioma was established through routine in vitro and in vivo assays.Results: CFI is overexpressed in glioma and its high levels correlated with poor outcomes in both TCGA and CGGA datasets. Furthermore, CFI was identified as an independent prognostic factor of glioma in the CGGA database. CFI knockdown in glioma cell lines inhibited growth in vitro and in vivo, whereas its ectopic expression increased glioma cell proliferation, migration, and invasion in vitro. CFI protein levels were also significantly higher in the glioma tissues resected from patients and correlated to worse prognosis.Conclusions: CFI is a potential prognostic biomarker in glioma and drives malignant progression.

show abstract

“…The gene polymorphisms of CYP24A1 and CYP17A1 have been closely correlated with the risk of liver, lung, stomach, and prostate cancers in a Chinese population [ 24 , 25 ]. Another study has shown that the expression of ABCC8 mRNA can be used as an independent prognostic index in patients with glioma and can predict the sensitivity of gliomas to temozolomide [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

Establishment of non-small-cell lung cancer risk prediction model based on prognosis-associated ADME genes

et al. 2021

View full text Add to dashboard Cite

Purpose: ADME genes are those involved in the absorption, distribution, metabolism, and excretion (ADME) of drugs. In this study, a non–small-cell lung cancer (NSCLC) risk prediction model was established using prognosis-associated ADME genes, and the predictive performance of this model was evaluated and verified. In addition, multifaceted difference analysis was performed on groups with high and low risk scores. Methods: An NSCLC sample transcriptome and clinical data were obtained from public databases. The prognosis-associated ADME genes were obtained by univariate Cox and lasso regression analyses to build a risk model. Tumor samples were divided into high-risk and low-risk score groups according to the risk score. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses of the differentially expressed genes and the differences in the immune infiltration, mutation, and medication reactions in the two groups were studied in detail. Results: A risk prediction model was established with seven prognosis-associated ADME genes. Its good predictive ability was confirmed by studies of the model’s effectiveness. Univariate and multivariate Cox regression analyses showed that the model’s risk score was an independent prognostic factor for patients with NSCLC. The study also showed that the risk score closely correlated with immune infiltration, mutations, and medication reactions. Conclusion: The risk prediction model established with seven ADME genes in this study can predict the prognosis of patients with NSCLC. In addition, significant differences in immune infiltration, mutations, and therapeutic efficacy exist between the high- and low-risk score groups.

show abstract

ABCC8 mRNA expression is an independent prognostic factor for glioma and can predict chemosensitivity

Cited by 17 publications

References 27 publications

ATP-binding cassette transporter sub-family C member 8, ABCC8, is a differentially expressed gene in brain metastatic human breast cancer.

ATP-binding cassette transporter sub-family C member 8, ABCC8, is a differentially expressed gene in brain metastatic human breast cancer.

A Candidate Prognostic Biomarker Complement Factor I Promotes Malignant Progression in Glioma

Establishment of non-small-cell lung cancer risk prediction model based on prognosis-associated ADME genes

Contact Info

Product

Resources

About