ABCB1 (MDR-1) pharmacogenetics of tacrolimus in renal transplanted patients: a Next Generation Sequencing approach

Abstract

Our results suggested that the ABCB1 variants had no effect on the risk of showing out of range Tac blood levels among renal transplanted patients.

CYP3A pharmacogenetics and tacrolimus disposition in adult heart transplant recipients

“…1 ABCB1 polymorphisms (rs1045642, rs1128503, and rs2032582) have not been consistently associated with tacrolimus doses or blood levels in various transplant populations, and thus were not included in this analysis. 18,20,22,[34][35][36][37][38][39][40][41][42][43] In summary, our study found that combined CYP3A genotype was associated with tacrolimus disposition in adult heart transplant recipients greater than one year post-transplant, but this effect was largely driven by the CYP3A5*3 allele in this cohort.…”

“…ABCB1 encodes the P‐glycoprotein efflux transporter, which plays a role in the intestinal absorption and biliary excretion of tacrolimus . ABCB1 polymorphisms (rs1045642, rs1128503, and rs2032582) have not been consistently associated with tacrolimus doses or blood levels in various transplant populations, and thus were not included in this analysis …”

Effect of the CYP3A5, CYP3A4, CYP3A7, ABCB1, POR and NR1I2 genes in the pharmacokinetics of tacrolimus in a pediatric cohort with stable serum concentrations after renal transplantation: study protocol.

“…Some studies report a sigEffect of the CYP3A5, CYP3A4, CYP3A7, ABCB1, POR and NR1I2 genes in the pharmacokinetics of tacrolimus in a pediatric cohort with stable serum concentrations after renal transplantation: study protocol. nificant association between rs1045642 and TAC dose (8,26) , however this association was not confirmed by other authors (27) .…”

Biomarkers and Next Generation Sequencing in Chronic Kidney Disease

“…NGS has been used to optimize the tacrolimus dosage in renal transplanted patients by examining ABCB1/MDR1 gene variants and to elucidate variants over the entire BKV genome and at CD8 T-cell epitopes in pediatric hematopoietic cell transplant and kidney transplant recipients with BKV infection. 19,20 In addition, detecting genetic mutation in renal cell carcinoma could be used to predict the prognosis and monitor therapeutic response. 15,21 Moreover, studying pathogenesis by NGS revealed and identified several key molecules and pathways in initiation of renal fibrosis or kidney disease progression and renal cell function.…”