ABCA2 as a therapeutic target in cancer and nervous system disorders

Down-regulation of the ATP-binding Cassette Transporter 2 (Abca2) Reduces Amyloid-β Production by Altering Nicastrin Maturation and Intracellular Localization

“…Abca2 Affects Proteolytic Processing of APP-As a putative cholesterol transporter, Abca2 has been suggested to contribute to AD by regulating intracellular sterol homeostasis (24). Forced Abca2 overexpression in Chinese hamster ovary cells showed an accumulation of unesterified low density lipoprotein cholesterol in the endosomal/lysosomal pathway (32), which is involved in proteolytic processing of APP to A␤ (33)(34)(35).…”

“…This led us to use genetic tools to investigate how cholesterol dyshomeostasis may lead to AD. We focused our attention on the ATP-binding cassette transporter-2 (Abca2) for two reasons: (i) Abca2 has been genetically linked to Alzheimer disease (22,23) and (ii) Abca2 plays a role in intracellular sterol trafficking (24).…”

ATP Binding Cassette transporters associated with chemoresistance: transcriptional profiling in extreme cohorts and their prognostic impact in a cohort of 281 acute myeloid leukemia patients

“…In addition to well known expected transporters (ABCB1 and ABCG2) ABCA2, a candidate regulator of neural transmembrane lipid transport, was relevant for drug resistance in AML and ALL, 15,27 and in a small cell lung cancer cell line resistant to mitoxantrone. 28,29 ABCG1 is actually, like ABCA2, a cholesterol transporter, but has not yet been demonstrated to be directly involved in resistance to chemotherapy. 30 Nevertheless, cholesterol alterations can influence other ABC proteins' localization and function, such as ABCB1, which might contribute to chemoresistance.…”

mRNA expression profile of multidrug-resistant genes in acute lymphoblastic leukemia of children, a prognostic value for ABCA3 and ABCA2

“…[8][9][10][11][12][13] There is much less data available on the other two members of this family, namely ABCA2 and ABCA3 genes, in terms of their role in leukemia and its prognosis. [14][15][16][17] Although not an ABC transporter, the expression of the lung resistance protein (LRP) has been implicated to increase in certain cases of resistance to chemotherapy in some studies. [18][19][20] Despite extensive research, the results on the role of genes of the ABC transporters superfamily and the LRP in ALL prognosis have been limited and controversial.…”