ABC of hypertension: The pathophysiology of hypertension

Beevers, Gareth

doi:10.1136/bmj.322.7291.912

Cited by 368 publications

(299 citation statements)

References 9 publications

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“…Several investigators have issued several nongenetic factors as predictors of hypertension status, like obesity, smoking habits, nutritional habits, physical activity and psychological status. [1][2][3][4][5][6][7] The results from our analysis remained similar, after controlling for several of the aforementioned factors, which enhance the eligibility of our reports.…”

Section: Demonstrated That Insupporting

confidence: 71%

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Lack of association between the C825T polymorphism in G-protein beta-3 subunit and arterial blood pressure levels in cardiovascular disease free individuals: the ATTICA epidemiological study

et al. 2006

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Section: Demonstrated That Insupporting

confidence: 71%

“…1 Polymorphisms in many genes have been implicated for predisposition to hypertension. [2][3][4] Siffert et al 4 first demonstrated a positive relationship between the polymorphism C825T in the GNB3 gene encoding the b3-subunit of heterotrimeric G proteins, with increased levels of blood pressure.…”

mentioning

confidence: 99%

Lack of association between the C825T polymorphism in G-protein beta-3 subunit and arterial blood pressure levels in cardiovascular disease free individuals: the ATTICA epidemiological study

et al. 2006

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“…Polymorphisms in several genes have been associated with BP levels (20). One of these is the gene encoding for α-adducin (ADD1).…”

Section: Discussionmentioning

confidence: 99%

The influence of α-adducin gene polymorphism on response of blood pressure to exercise in patients with hypertension

Alioğlu¹,

Ercan²,

Tengiz³

et al. 2010

Anadolu Kardiyol Derg

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Hipertansiyonu olan hastalarda egzersize kan basıncı cevabı üzerine α-addusin gen polimorfizminin etkisi 400 ÖZET Amaç: Egzersize cevap olarak aşırı kan basıncı yükselmesinin kardiyovasküler mortalitenin öngördürücüsü olduğu gösterilmiştir. Buna ilişkin mekanizmalar net olarak ortaya konmamış olsa da, altta yatan mekanizmaların kardiyovasküler sistemin yapısal anormallikleri ile ilgili olması muhtemeldir. Alfa addusin geni Gly460Trp polimorfizmi gösteren ve Trp460 alleli taşıyıcılarında artmış hipertansiyon riski söz konusudur. Bu çalışmada, hipertansif hastalarda α-addusin gen polimorfizminin egzersize olan kan basıncı cevabına etkisi araştırıldı.Yöntemler: Vaka-kontrollü, enine-kesitsel çalışmaya 49 hipertansif hasta (29 kadın ve 20 erkek; ortalama yaş 53.1±8.8 yıl) alındı. Tüm hastalara Bruce protokolüne göre egzersiz stres testi uygulandı. İstirahat, pik ve toparlanma sonu fazlarında elde edilen arteryel kan basıncı değerleri karşılaştırıldı. Hastalar α-addusin gen polimorfizmlerine göre sınıflandırıldı; Grup 1 Gly460Gly homozigot (n=28), Grup 2 ise Trp460Trp homozigot ve Gly460Trp heterozigottu (n=21). İstatistiksel analizde Ki-kare, eşleştirilmemiş t, Mann-Whitney U ve ANCOVA testleri kullanıldı. Bulgular: Ortalama egzersiz süre ve kapasiteleri her iki grupta benzer düzeylerdeydi. Alfa addusin geni için en az bir Trp460 alleli taşıyan hipertansif hastalarda, pik ve toparlanma sonu (3. dk) sistolik kan basınçlarında artmış bir cevap saptandı (p=0.036). Sonuç: Bulgularımız egzersize olan kan basıncı cevaplarındaki bireysel değişkenlikleri açıklamada, renal fonksiyonları ve/veya vazoreaktiviteyi değiştiren genetik varyasyonların etkili olabileceğini desteklemektedir. (Anadolu Kardiyol Derg 2010; 10: 400-4) Anahtar kelimeler: Gen polimorfizmi, α-addusin, esansiyel hipertansiyon, egzersiz ABSTRACTObjective: Clinical studies have indicated that an excessive response of blood pressure (BP) to exercise predicts risk of cardiovascular mortality. Although the mechanism responsible for the excessive BP response to exercise has not been revealed, there are some plausible mechanisms linking with underlying structural abnormalities in the cardiovascular system. Carriers of the Trp460 allele of the α-adducin Gly460Trp polymorphism have an increased risk of hypertension. The aim of the present study was to examine the influence of α-adducin gene polymorphism on response of BP to exercise in patients with hypertension. Methods: The cross-sectional observational study consisted of 49 hypertensive patients (29 women and 20 men; mean age, 53.1±8.8 years). All participants underwent a multistage exercise treadmill test according to the Bruce protocol. Arterial BPs were compared at rest, peak exercise and end of the recovery phase. Patients were classified according to their α-adducin gene polymorphisms; Gly460Gly homozygotes -Group 1 (n=28) and Trp460Trp homozygotes and Gly460Trp heterozygotes -Group 2 (n=21). Statistical analysis was performed using Chi-square, unpaired t, Mann-Whitney U and ANCOVA tests. Results: Mean exerci...

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“…About 90 to 95% of cases are primary hypertension, in which no medical cause can be found 20 . The remaining 5 to 10% of the cases are secondary hypertension, which are caused by other conditions that affect the arteries, kidneys, heart or endocrine system 21 . An excess of dietary salt is the most common environmental factor that contributes to the pathogenesis of hypertension [22][23][24][25][26] .…”

Section: Discussionmentioning

confidence: 99%

Untitled

2017

IJPSR

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Aim:To evaluate the antihypertensive effect of ethanolic extract of seeds of Phaseolus vulgaris Linn. (EEPV) on high salt diet induced hypertension in male rats. Methods: Male wistar rats (180-200g) received high salt diet (8% NaCl) and 1% saline water for 6 weeks, then cannulated for dosing of Enalapril, angiotensin converting enzyme inhibitor (0.5 mg/kg, i.v.) in standard group and EEPV (50 and 100 mg/kg, i.v.) in test group and measured mean blood pressure, systolic blood pressure, diastolic blood pressure and heart rate with the help of Power Lab 6 Pro after 60 minutes of treatment. Results: Elevated blood pressure of the animals was significantly (P < 0.05) decreased by EEPV (100 mg/kg, i.v). Enalapril, at the dose of 0.5 mg/kg, i.v. showed significant (P < 0.05) reduction in the elevated blood pressure. The antihypertensive activity of ethanolic extract of seeds of Phaseolus vulgaris Linn. may be due to the action on rennin-angiotensin system. The antihypertensive activity of EEPV might also be explained by the presence of phytochemical constituents like flavanoids and saponins in the plant. Conclusion:The work demonstrated that the concomitant administration of highsalt and EEPV elicits prevention of high salt-induced hypertension in rats. Overall, results justify and support the use of Phaseolus vulgaris Linn. as antihypertensive medicine.

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ABC of hypertension: The pathophysiology of hypertension

Cited by 368 publications

References 9 publications

Lack of association between the C825T polymorphism in G-protein beta-3 subunit and arterial blood pressure levels in cardiovascular disease free individuals: the ATTICA epidemiological study

Lack of association between the C825T polymorphism in G-protein beta-3 subunit and arterial blood pressure levels in cardiovascular disease free individuals: the ATTICA epidemiological study

The influence of α-adducin gene polymorphism on response of blood pressure to exercise in patients with hypertension

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