AB1347 Influence of low socioeconomic status on autoimmune rheumatic diseases:

Anaya, Juan Manuel; Amaya-Amaya, Jenny; Amador-Patarroyo, Manuel J.; Herrera-Diaz, Catalina; Quintero, O. Lucía; Cárdenas-Roldán, Jorge; Giraldo-Villamil, J.; Barragan-Ardila, C.; Caro-Moreno, Julián; De-San-Vicente, Z.; Cruz‐Tapias, Paola; Rodríguez, Alberto Rodríguez; Mantilla, Rubén D.; Rojas-Villarraga, Adriana

doi:10.1136/annrheumdis-2012-eular.1341

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Factors Associated With Polyautoimmunity In Sjö Gren Syndrome1

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2016

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“…21 The association between polyautoimmunity and low socioeconomic status in SS patients has been highlighted. 69 This finding is in concordance with the influence of socioeconomic status on chronic diseases in which low socioeconomic status is associated with morbidity and mortality. 70 The influence of infection on polyautoimmunity has been evaluated in some studies.…”

Section: Factors Associated With Polyautoimmunity In Sjö Gren Syndromesupporting

confidence: 81%

Polyautoimmunity in Sjögren Syndrome

Anaya

Rojas-Villarraga

Mantilla

et al. 2016

Rheumatic Disease Clinics of North America

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Section: Factors Associated With Polyautoimmunity In Sjö Gren Syndromesupporting

confidence: 81%

Polyautoimmunity in Sjögren Syndrome

Anaya

Rojas-Villarraga

Mantilla

et al. 2016

Rheumatic Disease Clinics of North America

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The Autoimmune Ecology

et al. 2016

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Autoimmune diseases (ADs) represent a heterogeneous group of disorders that affect specific target organs or multiple organ systems. These conditions share common immunopathogenic mechanisms (i.e., the autoimmune tautology), which explain the clinical similarities they have among them as well as their familial clustering (i.e., coaggregation). As part of the autoimmune tautology, the influence of environmental exposure on the risk of developing ADs is paramount (i.e., the autoimmune ecology). In fact, environment, more than genetics, shapes immune system. Autoimmune ecology is akin to exposome, that is all the exposures – internal and external – across the lifespan, interacting with hereditary factors (both genetics and epigenetics) to favor or protect against autoimmunity and its outcomes. Herein, we provide an overview of the autoimmune ecology, focusing on the immune response to environmental agents in general, and microbiota, cigarette smoking, alcohol and coffee consumption, socioeconomic status (SES), gender and sex hormones, vitamin D, organic solvents, and vaccines in particular. Inclusion of the autoimmune ecology in disease etiology and health will improve the way personalized medicine is currently conceived and applied.

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AB1347 Influence of low socioeconomic status on autoimmune rheumatic diseases:

Cited by 2 publications

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Polyautoimmunity in Sjögren Syndrome

Polyautoimmunity in Sjögren Syndrome

The Autoimmune Ecology

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