Ab1252 functional Status Changes Associated With Inflammatory Arthritis in Republic of Moldova

Abstract

BackgroundInflammatory joint disease is a burden to the patient and society, due to medical costs and the impact it has on the health-related quality of life. Functional status plays a significant role in quality of life impairment.ObjectivesTo study and compare functional status changes between different inflammatory joint diseases and degenerative joint disease.Methods1500 patients with inflammatory joint disease and 400 patients with degenerative joint disease were included in this study. In the first group, 645 (43.0%) were diagnosed with rheumatoid arthritis, 330 (22.0%) - psoriatic arthritis, 100 (6.7%) - ankylosing spondylitis, 200 (13.3%) - axial spondyloarthritis, 135 (9.0%) - gout, 20 (1.3%) - other crystal arthritis, 45 (3.0%) - early arthritis and 25 (1.7%) with other arthritis. Physical exam with functional status was assessment were performed. Descriptive statistics and Mann-Whitney U tests were used to compare the study groups, as well as the subgroups within the inflammatory disease group.ResultsBoth groups were comparable according to sex, with a predominance of female sex (χ2 = 86.4 and 30.74 respectively, p<0.001), and no difference in sex distribution (mean ranks of U test – 950.98 and 967.44, p = 0.524). Mean age was significantly lower in the inflammatory joint disease group (44.76 vs 60.19, p<0.001). The Mann-Whitney U test showed a significantly greater mean rank in the inflammatory disease group (999.07 vs 790.66, p<0.001), suggesting an overall higher functional class, and thus worse functional status in the inflammatory joint disease group. Further analysis using the same method, between subgroups in the inflammatory joint disease group, showed a higher mean rank (worse functional status) in patients with rheumatoid arthritis, when compared with psoriatic arthritis (501.95 vs 460.73, p<0.05) and early arthritis (352.24 and 248.83, p<0.001). Psoriatic arthritis showed a higher mean rank, compared to axial spondyloarthritis (282.88 vs 254.97 p<0.05) and early arthritis (193.34 vs 148.83, p<0.01). Gout patients showed a higher mean rank (worse functional status), when compared to rheumatoid arthritis (453.65 vs 377.28, p<0.001), psoriatic arthritis (281.33 vs 213.23, p<0.001), ankylosing spondylitis (127.07 vs 105.75, p<0.05), axial spondyloarthritis (184.67 vs 156.75, p<0.01) and early arthritis (101.70 vs 56.89, p<0.001), thus making it the subgroup associated with the poorest functional status. Ankylosing spondylitis showed a higher mean rank, when compared to psoriatic arthritis (238.13 vs 208.64, p<0.05), axial spondyloarthritis (151.75 vs 129.88, p<0.05) and early arthritis (81.63 vs 53.83, p<0.001). Axial spondyloarthritis and other crystalline arthritis subgroups both showed higher mean ranks compared to early arthritis (130.0 vs 91.89 and 43.2 vs 28.56 respectively, p<0.01), making early arthritis the subgroup associated with the best functional status. No significant differences were found when comparing rheumatoid arthritis with ankylosing spondylitis, axial spondyloarthritis and...