AB1128 Helicobacter pylori in systemic lupus erythematosus its association with endoscopic and histopathologic findings

Abstract

BackgroundHelicobacter pylori (Hp) is a Gram-negative bacteria and the cause of most of the chronic gastric infections and its prevalence is above 50% worldwide. This infection is a well-known risk factor to gastric MALT lymphoma but also could be the trigger of several autoimmune diseases such as immune thrombocytopenic purpura and systemic lupus erythematosusObjectivesTo determine the frequency of H pylori in systemic lupus erythematosus patients (SLE).MethodsA cross-sectional study was done in patients who fulfilled the 2012 SLICC criteria for SLE and were willing to sign the informed consent to be subjected to endoscopic procedure. The tissue sample was analyzed by pathologist. We used mean and standard deviation to describe the data, to compare both groups Student t test was done and for continuous variables we used chi-square; the correlation analysis was performed withResultsTwenty two SLE patients were included and we chose a control group from database of endoscopic clinic with diagnosis of functional dyspepsia. Mean age of study group was 31 vs 48 year-old, 95% were women, 32% with immunosuppressant and 95% were taking antimarials. The frequency of Hp in SLE patients was 60%, dsDNA and anti-Ro autoantibodies were associated with the presence of Hp; the study group had more frequency of nodular gastritis, metaplasia and dysplasia. Seventy per cent of patients had less than 5 years of diagnosis.ConclusionsWe found a high frequency of H pylori infection in patients with SLE. Metaplastic and dysplastic changes were also more prevalent in the SLE group. Our data suggest that Hp infection took place in early stages of disease.References Daniel S Smyk, Andreas L Koutsoumpas, Maria G Mytilinaiou, Eirini I Rigopoulou, Lazaros I Sakkas, Dimitrios P Bogdanos. Helicobacter pylori and autoimmune disease: Cause or bystander. World J Gastroenterol 2014 January.Sarfaraz Ahmed Hasni Role of helicobacter pylori infection in autoimmune diseases. Curr Opin Rheumatol. 2012 July; 24(4): 429–434. Acknowledgementsno clinficts of interest.Disclosure of InterestNone declared

Increased Risk of Systemic Lupus Erythematosus in Patients With Helicobacter pylori Infection: A Nationwide Population-Based Cohort Study

“…Additionally, our study found that patients aged >65 years with HP infection had a lower risk of SLE but did not reach statistical significance. By contrast, one recent study by Prado et al showed high HP frequency in patients with SLE through endoscopic and histopathological findings (26). These investigations have some drawbacks, but most of them have shown a negative correlation between HP infection and SLE.…”