AB1067 Prevalence of fibromyalgia in patients with painful knee oa

Abstract

BackgroundFibromyalgia (FM) has been conceptualised as a central nervous system (CNS) disorder, characterised by augmented sensory processing and inability to modulate pain effectively[.1 Global mean prevalence of FM is 2.7% with female/male ratio of 4:1. Several studies highlight the importance of central sensitisation (CS) as a significant manifestation of neuropathic pain symptoms in knee osteoarthritis (OA).2–3 Possible similar mechanisms of chronic pain maintenance in OA – structural pathology, and FM – central sensitivity syndrome, provoke further interest in investigation of any links between these conditions. Therefore, prevalence of FM in patients with painful knee OA is of considerable interest.ObjectivesThe purpose of this study was to evaluate the prevalence of fibromyalgia (FM) in patients with painful knee OA.MethodsThe study involved 92 patients (63 females and 29 males) with painful knee OAACR 1986 Osteoarthritis Knee Criteria) with non-surgical management aged 59.4±14.3 (M±SD) yrs.4 Radiographic findings for OA were classified according to Kellgren-Lawrence scale grading.5 FM was diagnosed in these subjects if both ACR 1990 and 2010 criteria were met.5–6 ResultsFM was diagnosed in 21painful knee OA patients (22.83%). Among female patients FM was confirmed in 19 from 63 subjects (30.16%) compared to 2 from 29 male patients (6.90%). No relationship was found between the radiologic stage of the knee OA and FM prevalence in the investigated subjects.ConclusionsFM prevalence is relatively high in painful knee OA patients, mostly female. Further studies investigating possible FM impact on pain modulation, functional disability and quality of life in painful knee OA are needed.References[1] Petersel DL, Dror V, Cheung R. Central amplification and fibromyalgia: disorder of pain processing. J Neurosci Res. 2011;89:29–34.[2] Arendt-Nielsen L, Nie H, Laursen MB, Laursen BS, et al. Sensitization in patients with painful knee osteoarthritis. Pain. 2010 Jun;149(3):573–81.[3] Finan PH, Buenaver LF, Bounds SC, et al. Discordance between pain and radiographic severity in knee osteoarthritis: findings from quantitative sensory testing of central sensitization. Arthritis Rheum. 2013Feb;65(2):363–72.[4] Altman R, Asch E, Bloch D, et al. Development of criteria for the classification and reporting of osteoarthritis. Classification of osteoarthritis of the knee. Diagnostic and Therapeutic Criteria Committee of the American Rheumatism Association. Arthritis Rheum. 1986;29:1039–1049.[5] Kellgren JH, Lawrence JS. Radiological assessment of osteo-arthrosis. Ann Rheum Dis.1957;16:494–502.[6] Wolfe F, Smythe HA, Yunus MB, et al. The American College of Rheumatology 1990 criteria for the classification of fibromyalgia. Report of the Multicenter Criteria Committee. Arthritis Rheum1990;33:160–72.[7] Wolfe F, Clauw DJ, FitzCharles MA, et al. The American College of Rheumatology preliminary diagnostic criteria for fibromyalgia and measurement of symptom severity. Arthritis Care Res (Hoboken)2010;62:600–10.Disclosure of InterestNo...

Pain in psoriatic arthritis and hand osteoarthritis

“…Fibromyalgia is considered a disease of central sensitization by some [31] and 59 patients in the cohort fulfilled the criteria for fibromyalgia (39% of patients with hand-OA and 52% with PsA).This corresponds with previous observations in PsA cohorts (17% to 64 %) [34,84,142,258,259]. No similar trials have examined the prevalence of patients with hand-OA and concomitant fibromyalgia, but due to the large prevalence of female patients with hand-OA, it is expected that a greater percentage will have concomitant fibromyalgia compared with patients with knee-OA where the prevalence is previously shown to be 10% to 35% [75,115,165]. Patients with fibromyalgia reported higher HAQ and catastrophizing scores than patients without fibromyalgia, a finding which is supported by similar trials in patients with PsA [34].…”

Fibromyalgia in Early Osteoarthritis; A Tertiary Care Hospital Experience

“…[22][23][24][25] It was observed that fibromyalgia was found in 43.5% of patients with early osteoarthritis. In comparison to this, studies have demonstrated a relatively lower frequency of 6% 26 , 10%, 27 and 22.83% 28 of FM among their OA patients. However, by considering such studies, the cohort was based on established OA while the current study considered the early knee OA patients only.…”

“…However, similar results have been shown in the established osteoarthritis patients as compared to early OA patients included as compared to the current study. Bergman et al 27 reported a 56% prevalence of Fibromyalgia in female patients of OA. They too did not segregate the early OA from established OA.…”

Quantitative sensory testing, psychological profiles and clinical pain in patients with psoriatic arthritis and hand osteoarthritis experiencing pain of at least moderate intensity

“…The large variation in prevalence of cFM could be due to difference in detection criteria for fibromyalgia or heterogeneity of patients with PsA (active arthritis, number of female participants etc.). No previous studies have examined the proportion of cFM among patients with hand‐OA, but the prevalence is estimated to be 10% to 35% (Dzekan & Stanislavchuk, 2018; Haliloglu et al, 2014; Mahgoub et al, 2020) in patients with knee‐OA. Greater co‐occurrence in hand‐OA in this study could be anticipated due to the greater number of women affected by hand‐OA or due to participants experiencing at least moderate pain intensity.…”