Abstract:Background:Incidence and severity of gout and calcium pyrophosphate deposition disease (CPPD) increase with age (1). Aging is associated with immune senescence, leading to a deregulation of the innate immune system and hence inflammation (2). MRI studies hinted on a significantly higher synovial inflammation in older compared to younger arthritis patients(3). Whether inflammatory responses to synovial crystals are more pronounced in elderly patients or not is unknown.Objectives:To test the hypothesis whether a… Show more
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