Abstract:Background
Bisphosphonates are widely prescribed and highly effective at limiting the bone loss in senile osteoporosis in both men and women. Although they are generally well tolerated, potential adverse effects may limit bisphosphonate use for longer periods. In addition these drugs accumulate in bone and continue to produce a therapeutic effect – that's why the idea of a drug holiday in this case received an increasing attention during last years. While rheumatologists' reasons to support this holiday are wi… Show more
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