Ab0709 influence of Dietetary Intakes on Spondyloarthritis : An Observational Prospective Study

Abstract

Background:Dysbiosis can be found in inflammatory joint diseases and induces alterations of the protective function of the intestinal barrier (1). Yet intestinal inflammation exists in ankylosing spondylitis, which is as much severe as the disease is active (2). Benefits of diets and their influence on the microbiota diversity and inflammation deserve to be studied in spondyloarthritis.Objectives:The aim of the study was to investigate the nutritional profil in active spondyloarthritis.Methods:An observational prospective monocentric study based in a french rheumatology department based in Limoges was conducted between February and July 2018, demographic and disease data were collected, in addition to the treatments and the food frequency questionnaire. Voluntary patients over 18 years of age with spondyloarthritis defined by aSAS classification were included. Patients with a diagnosis of inflammatory bowel disease or a bariatric surgery history were excluded of the study. The primary outcome was the correlation between omega-3, vitamin C, refined sugars, fibers and ultra-processed food intakes and the disease activity assessed by aSDAS CRP and BASDAI scores.Results:Among 140 patients included, there was no statistically significant difference in omega-3, vitamin C, refined sugars, fibers or ultra-processed food intakes between patients with active spondyloarthritis (BASDAI ≥ 4 or aSDAS CRP ≥ 1,3) and very active (ASDAS ≥ 2,1) and patients with unactive disease. The quality of life score and fatigue score were more important in the active and very active disease forms, likewise for the digestive symptoms but there was no link founded in the different nutrients intakes, neither with the associated treatment.Conclusion:Althouth our study did not find any nutritional profil in active spondyloarthritis, there was an alteration of quality of life and more digestive symptoms in the active group. Future researches are however required to explore the impact of dietatary intakes on the disease activity of spondyloarthritis.References[1] Costello M-E, Robinson PC, Benham H, Brown MA. The intestinal microbiome in human disease and how it relates to arthritis and spondyloarthritis. Best Pract Res Clin Rheumatol. Avr2015;29(2):202-12[2] Hascelik G, Oz B, Olmez N, Memis a, Yoruk G, Unsal B, et al. Association of macroscopic gut inflammation with disease activity, functional status and quality of life in ankylosing spondylitis. Rheumato int. mai 2009;29(7):755-81)Disclosure of interests:None declared