Abstract:BackgroundSubsets of GCA have extensive vascular involvement, termed Large Vessel GCA (LV-GCA), seen in 12%–37% depending on imaging used. These patients have higher relapse rates and are more often refractory to glucocorticoids (GC), requiring steroid-sparing treatment to minimise GC toxicity and vascular complications. Diagnosis is reliant upon imaging, given the relative inaccessibility of tissue for histological analysis beyond temporal artery biopsy (TAB). If axillary and subclavian arteries are often aff… Show more
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