Ab0507 assessment of Fibrinogen to Albumin Ratio in Radiographic Axial Spondyloarthritis: Correlation With Disease Activity

Abstract

Background:Radiographic axial spondyloarthritis is a chronic inflammatory disease that involves the spine and the sacroiliac joints. No specific biomarker that reflects disease activity is yet available.Objectives:This study aimed to assess the relationship between fibrinogen (Fib) to albumin (ALB) ratio (FAR) and disease activity in radiographic axial spondyloarthritis.Methods:We performed a cross-sectional study including 51 patients with radiographic axial spondyloarthritis. Disease activity was assessed using Ankylosing Spondylitis Disease Activity Score (ASDAS). C-reactive protein (CRP), fibrinogen (Normal value: 2 -4g/L), erythrocyte sedimentation rate (ESR) and albumin levels (Normal value: 35 -50 g/L) were measured. The fibrinogen to albumin ratio (FAR) was calculated. We excluded patients with infectious disease, hematological disease, and those with malabsorption syndromeStatistical analysis was performed using SPSS 26.Results:The study included 43 males and 8 females with a mean age of 41.25 ± 10.97 years. The mean disease duration was 117.92 (85.4 months). The mean fibrinogen and albumin levels were 3.94 ± 1.24 g/L and 36.94 ± 5.89 g/L, respectively. Fibrinogen level was elevated in 45% patients and albumin levels was decreased in 51% cases. Mean FAR was 0.11 ± 0.44.ESR levels were elevated in 67% with a mean of 40.22 ± 34.64 mm. CRP levels were high in 61% with a mean of 28.57 ± 33.25 mg/L. Mean ASDAS was 3.32 ± 1. 27 patients had very high disease activity (ASDAS>3.5).Significant correlation was found between FAR and following parameters: ESR (r = 0.836, p< 0.001), CRP (r = 0.785, p < 0.001), and ASDAS (r = 0.463, P < 0.001).The ability of FAR to distinguish patients with very high disease activity from those without very high disease activity was excellent, with Aire under the curve of 0.819. The optimal FAR cutoff value with the highest accuracy was 0,1065 with a sensitivity of 0,792 and specificity of 0,852.Conclusion:Our study showed that fibrinogen to albumin ratio correlate with ESR, CRP and ASDAS. This finding suggests that this ratio may be a used to assess disease activity in radiographic axial spondyloarthritis (1).References:[1]Liu M, Huang Y, Huang Z, Zhong Z, Deng W, Huang Z, et al. The role of fibrinogen to albumin ratio in ankylosing spondylitis: Correlation with disease activity. Clin Chim Acta. juin 2020;505:136-40.Disclosure of Interests:None declared.